Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   QMM27_RS08625 Genome accession   NZ_AP025939
Coordinates   1700919..1702175 (-) Length   418 a.a.
NCBI ID   WP_000642706.1    Uniprot ID   A0A098Z3K2
Organism   Streptococcus pneumoniae strain Utah_35B-24     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1693803..1716062 1700919..1702175 within 0


Gene organization within MGE regions


Location: 1693803..1716062
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QMM27_RS08585 (Utah35B_16860) - 1693803..1694597 (-) 795 WP_001101210.1 hypothetical protein -
  QMM27_RS08590 (Utah35B_16870) - 1695005..1695430 (-) 426 WP_000204065.1 hypothetical protein -
  QMM27_RS08595 (Utah35B_16880) - 1695559..1695918 (-) 360 WP_000749822.1 hypothetical protein -
  QMM27_RS08600 (Utah35B_16890) - 1695964..1696170 (-) 207 WP_000366091.1 hypothetical protein -
  QMM27_RS08605 (Utah35B_16900) - 1696157..1696330 (-) 174 WP_000289349.1 helix-turn-helix transcriptional regulator -
  QMM27_RS08610 (Utah35B_16910) lytA 1696689..1697645 (-) 957 WP_000405235.1 N-acetylmuramoyl-L-alanine amidase LytA -
  QMM27_RS08615 (Utah35B_16920) - 1698021..1699391 (-) 1371 WP_001036271.1 MATE family efflux transporter -
  QMM27_RS08620 (Utah35B_16930) recA 1699698..1700864 (-) 1167 WP_001085462.1 recombinase RecA Machinery gene
  QMM27_RS08625 (Utah35B_16940) cinA 1700919..1702175 (-) 1257 WP_000642706.1 competence/damage-inducible protein A Machinery gene
  QMM27_RS08630 (Utah35B_16950) - 1702260..1703276 (-) 1017 WP_000239282.1 LCP family protein -
  QMM27_RS08635 (Utah35B_16960) - 1703284..1703802 (-) 519 WP_000455537.1 GNAT family N-acetyltransferase -
  QMM27_RS08640 (Utah35B_16970) tsaE 1703792..1704235 (-) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  QMM27_RS08645 (Utah35B_16980) comM 1704452..1705072 (-) 621 WP_084572333.1 hypothetical protein Regulator
  QMM27_RS08650 (Utah35B_16990) - 1705378..1706241 (-) 864 WP_001093641.1 helix-turn-helix transcriptional regulator -
  QMM27_RS08655 (Utah35B_17000) - 1706433..1706603 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  QMM27_RS08660 (Utah35B_17010) pneA1 1706706..1706930 (+) 225 WP_000181087.1 two-peptide bacteriocin subunit PneA1 -
  QMM27_RS08665 (Utah35B_17020) pneA2 1706937..1707125 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  QMM27_RS08670 (Utah35B_17030) lanM 1707240..1710230 (+) 2991 WP_000875573.1 type 2 lanthipeptide synthetase LanM -
  QMM27_RS08675 (Utah35B_17040) - 1710580..1711284 (+) 705 WP_001033170.1 flavodoxin family protein -
  QMM27_RS08680 (Utah35B_17050) - 1711265..1712194 (+) 930 WP_000912954.1 M50 family metallopeptidase -
  QMM27_RS08685 (Utah35B_17060) - 1712191..1714299 (+) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  QMM27_RS08690 (Utah35B_17070) - 1714323..1716062 (+) 1740 WP_000699969.1 S8 family serine peptidase -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45062.40 Da        Isoelectric Point: 4.5211

>NTDB_id=95456 QMM27_RS08625 WP_000642706.1 1700919..1702175(-) (cinA) [Streptococcus pneumoniae strain Utah_35B-24]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFEGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=95456 QMM27_RS08625 WP_000642706.1 1700919..1702175(-) (cinA) [Streptococcus pneumoniae strain Utah_35B-24]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTGAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGATCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)

Competence-damaged protein (CinA)

(262-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A098Z3K2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae Rx1

99.761

100

0.998
  cinA Streptococcus pneumoniae R6

99.761

100

0.998
  cinA Streptococcus pneumoniae TIGR4

99.522

100

0.995
  cinA Streptococcus pneumoniae D39

99.522

100

0.995
  cinA Streptococcus mitis SK321

93.541

100

0.935
  cinA Streptococcus mitis NCTC 12261

93.301

100

0.933
  cinA Streptococcus mutans UA159

70.813

100

0.708
  cinA Streptococcus suis isolate S10

55.048

99.522

0.548
  cinA Bacillus subtilis subsp. subtilis str. 168

45.455

100

0.455

Multiple sequence alignment