Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   WFA81_RS09900 Genome accession   NZ_CP147890
Coordinates   2044138..2045379 (-) Length   413 a.a.
NCBI ID   WP_012491282.1    Uniprot ID   A0A5Q8BSD6
Organism   Lacticaseibacillus paracasei strain CUDS0725     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 2039113..2072347 2044138..2045379 within 0


Gene organization within MGE regions


Location: 2039113..2072347
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  WFA81_RS09880 - 2039113..2040375 (-) 1263 WP_016379935.1 helicase-related protein -
  WFA81_RS09885 - 2040403..2041053 (+) 651 WP_012491283.1 YigZ family protein -
  WFA81_RS09890 rny 2041147..2042718 (-) 1572 WP_003657913.1 ribonuclease Y -
  WFA81_RS09895 recA 2043020..2044081 (-) 1062 WP_003598111.1 recombinase RecA Machinery gene
  WFA81_RS09900 cinA 2044138..2045379 (-) 1242 WP_012491282.1 competence/damage-inducible protein A Machinery gene
  WFA81_RS09905 pgsA 2045754..2046347 (-) 594 WP_003564171.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  WFA81_RS09910 - 2046344..2047273 (-) 930 WP_003593861.1 helix-turn-helix domain-containing protein -
  WFA81_RS09915 - 2047360..2048088 (-) 729 WP_003569514.1 SDR family oxidoreductase -
  WFA81_RS09920 - 2048088..2049380 (-) 1293 WP_126139143.1 pitrilysin family protein -
  WFA81_RS09925 - 2049377..2050639 (-) 1263 WP_012491281.1 pitrilysin family protein -
  WFA81_RS09930 - 2050648..2052969 (-) 2322 WP_003604697.1 DNA translocase FtsK -
  WFA81_RS09935 - 2053142..2053552 (-) 411 WP_003564159.1 DUF1149 family protein -
  WFA81_RS09940 trmL 2053679..2054188 (-) 510 WP_003564157.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
  WFA81_RS09945 - 2054443..2055285 (-) 843 WP_012491280.1 methyltransferase domain-containing protein -
  WFA81_RS09950 - 2055351..2056298 (+) 948 WP_003564155.1 magnesium transporter CorA family protein -
  WFA81_RS09955 - 2056538..2057515 (+) 978 WP_024109435.1 GMP reductase -
  WFA81_RS09960 rpsN 2057643..2057912 (+) 270 WP_003564153.1 30S ribosomal protein S14 -
  WFA81_RS09965 - 2058024..2058401 (-) 378 WP_014566472.1 PTS glucitol/sorbitol transporter subunit IIA -
  WFA81_RS09970 - 2058673..2059713 (+) 1041 WP_012491278.1 lactonase family protein -
  WFA81_RS09975 - 2059916..2060734 (+) 819 WP_014566471.1 undecaprenyl-diphosphate phosphatase -
  WFA81_RS09980 - 2060756..2061391 (+) 636 WP_003569480.1 copper homeostasis protein CutC -
  WFA81_RS09985 - 2061548..2062606 (+) 1059 WP_012491276.1 FAD:protein FMN transferase -
  WFA81_RS09990 - 2062715..2063617 (-) 903 WP_012491275.1 RluA family pseudouridine synthase -
  WFA81_RS09995 - 2063617..2064414 (-) 798 WP_003564146.1 NAD kinase -
  WFA81_RS10000 - 2064416..2065087 (-) 672 WP_003564145.1 GTP pyrophosphokinase family protein -
  WFA81_RS10005 - 2065281..2065874 (+) 594 WP_003601679.1 CYTH domain-containing protein -
  WFA81_RS10010 - 2065944..2066579 (+) 636 WP_003601677.1 DsbA family protein -
  WFA81_RS10015 - 2066769..2067824 (-) 1056 WP_003569473.1 competence protein CoiA family protein -
  WFA81_RS10020 - 2067934..2069277 (-) 1344 WP_014951764.1 PFL family protein -
  WFA81_RS10025 - 2069326..2069592 (-) 267 WP_003564140.1 ACT domain-containing protein -
  WFA81_RS10030 - 2069783..2071111 (+) 1329 WP_012491272.1 metallophosphoesterase -
  WFA81_RS10035 - 2071349..2072347 (+) 999 WP_012490951.1 IS30 family transposase -

Sequence

Protein


Download         Length: 413 a.a.        Molecular weight: 44326.69 Da        Isoelectric Point: 6.0028

>NTDB_id=949298 WFA81_RS09900 WP_012491282.1 2044138..2045379(-) (cinA) [Lacticaseibacillus paracasei strain CUDS0725]
MQAEIIAVGTEILMGQITNTNGAYMAKQLTALGIDSYHQQVVGDNGPRLEEAIKLAESRSNLVILIGGLGPTPDDLTKQT
LAAHLNRKLVEDPDAMAKLQARVKQQQRPMTPNNQLQAMYPEGADILVNRVGLAVGAWIVNGQHTYVLLPGPPKEFVPMV
DHELLPRLAKWSGHAEIMVSRVLRFFGIGESQLVTDLDDLIANQTDPTIATYIKDHEVTVRVTASGATEKDADAKLEPMI
GAIMDRDGQYFYGYGDDNSLAKELVKTLAANDMQITAAESLTAGAFQAALGDVPGVSTYFKGGFVTYSLATKAAFLAIDA
RELAAHGVVSAFTAKAMAEHARRKAAADISVSFTGVAGPDTLEGQPAGTVWIGLARRGQLPEAHVYHFPGGRNDVRQRAV
MTGMMLALRALQA

Nucleotide


Download         Length: 1242 bp        

>NTDB_id=949298 WFA81_RS09900 WP_012491282.1 2044138..2045379(-) (cinA) [Lacticaseibacillus paracasei strain CUDS0725]
ATGCAAGCAGAGATTATTGCTGTCGGGACAGAGATCCTGATGGGACAGATTACTAACACAAATGGTGCCTATATGGCTAA
GCAACTGACAGCACTGGGTATTGATAGCTACCATCAACAGGTGGTGGGAGACAACGGGCCGCGACTTGAGGAGGCCATTA
AGTTGGCGGAAAGTCGCAGTAATTTAGTTATTTTGATTGGCGGGTTAGGACCGACACCAGATGATCTGACCAAGCAAACA
TTGGCAGCGCACTTGAACCGCAAATTGGTTGAAGATCCTGACGCTATGGCTAAATTACAGGCGCGCGTCAAGCAACAGCA
GCGGCCAATGACGCCTAATAATCAATTACAGGCCATGTATCCGGAAGGCGCCGATATTTTGGTCAATCGGGTTGGCTTAG
CGGTTGGCGCGTGGATCGTCAATGGGCAGCACACCTATGTCTTATTGCCGGGACCACCGAAGGAATTCGTTCCGATGGTT
GATCATGAACTGCTGCCGCGGCTAGCAAAATGGAGCGGCCACGCGGAAATTATGGTCAGCCGGGTCTTACGTTTCTTTGG
CATTGGCGAATCGCAACTAGTGACAGATCTGGACGACTTGATTGCCAACCAAACCGATCCGACCATTGCAACTTATATCA
AGGATCATGAGGTGACGGTGCGCGTCACTGCCAGTGGCGCTACCGAAAAAGACGCTGATGCAAAGTTAGAACCAATGATC
GGTGCCATCATGGATCGTGATGGTCAATATTTTTACGGCTACGGTGACGACAATAGTTTGGCAAAAGAGCTTGTGAAGAC
GCTTGCGGCAAATGATATGCAAATTACTGCAGCTGAGAGTTTGACTGCTGGCGCATTTCAAGCAGCGTTAGGCGATGTGC
CGGGGGTATCCACTTATTTTAAGGGCGGTTTTGTCACTTACTCACTTGCAACAAAGGCCGCTTTTTTGGCAATTGATGCT
CGCGAATTAGCGGCACACGGAGTTGTCAGCGCATTTACAGCCAAGGCGATGGCTGAACATGCTCGGCGTAAGGCAGCGGC
GGATATAAGTGTCAGCTTTACCGGCGTTGCCGGTCCAGACACGCTGGAAGGACAGCCTGCTGGTACGGTTTGGATCGGTT
TAGCGCGGCGCGGCCAACTGCCTGAAGCACATGTTTACCATTTTCCTGGCGGTCGCAATGATGTTCGGCAGCGTGCTGTG
ATGACTGGTATGATGCTTGCATTAAGGGCGCTGCAGGCCTAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)

Competence-damaged protein (CinA)

(258-410)

Damage-inducible protein CinA KH domain (CinA_KH)

(180-253)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5Q8BSD6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mitis NCTC 12261

51.887

100

0.533
  cinA Streptococcus mitis SK321

51.773

100

0.53
  cinA Streptococcus pneumoniae TIGR4

51.415

100

0.528
  cinA Streptococcus mutans UA159

52.174

100

0.523
  cinA Streptococcus pneumoniae Rx1

50.943

100

0.523
  cinA Streptococcus pneumoniae R6

50.943

100

0.523
  cinA Streptococcus pneumoniae D39

50.708

100

0.521
  cinA Bacillus subtilis subsp. subtilis str. 168

45.012

99.516

0.448
  cinA Streptococcus suis isolate S10

42.063

91.525

0.385