Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGA/cglA/cilD   Type   Machinery gene
Locus tag   ACD268_RS10430 Genome accession   NZ_CP168299
Coordinates   2003080..2004021 (-) Length   313 a.a.
NCBI ID   WP_000249555.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain FC1     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1998080..2009021
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACD268_RS10395 (ACD268_10395) - 1998288..1998434 (-) 147 WP_000389580.1 hypothetical protein -
  ACD268_RS10400 (ACD268_10400) - 1998829..1998951 (-) 123 WP_000343850.1 hypothetical protein -
  ACD268_RS10405 (ACD268_10405) - 1999025..1999300 (-) 276 WP_001094380.1 hypothetical protein -
  ACD268_RS10410 (ACD268_10410) - 1999461..2000213 (+) 753 WP_001023158.1 XRE family transcriptional regulator -
  ACD268_RS10415 (ACD268_10415) - 2000215..2000415 (+) 201 WP_000064302.1 hypothetical protein -
  ACD268_RS10420 (ACD268_10420) - 2000589..2002034 (+) 1446 WP_024478469.1 recombinase family protein -
  ACD268_RS10425 (ACD268_10425) comGB/cglB 2002116..2003132 (-) 1017 WP_074017570.1 competence type IV pilus assembly protein ComGB Machinery gene
  ACD268_RS10430 (ACD268_10430) comGA/cglA/cilD 2003080..2004021 (-) 942 WP_000249555.1 competence type IV pilus ATPase ComGA Machinery gene
  ACD268_RS10435 (ACD268_10435) - 2004096..2004461 (-) 366 WP_000286415.1 DUF1033 family protein -
  ACD268_RS10440 (ACD268_10440) - 2004612..2005670 (-) 1059 WP_000649466.1 zinc-dependent alcohol dehydrogenase family protein -
  ACD268_RS10445 (ACD268_10445) nagA 2005833..2006984 (-) 1152 WP_001134457.1 N-acetylglucosamine-6-phosphate deacetylase -
  ACD268_RS10450 (ACD268_10450) - 2007137..2008954 (-) 1818 WP_001220838.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 313 a.a.        Molecular weight: 35561.49 Da        Isoelectric Point: 6.0083

>NTDB_id=935481 ACD268_RS10430 WP_000249555.1 2003080..2004021(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain FC1]
MVQEIAQEIIRSARKKGAQDIYFVPKLDAYELHMRVGDERCKIGSYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYA
YDQKMASLRLSTVGDYRGHESLVIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELSKSLFKGQQ
VMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDSETARAVVRASLTGATVFSTIHAKSIRGVY
ERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFANRDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS

Nucleotide


Download         Length: 942 bp        

>NTDB_id=935481 ACD268_RS10430 WP_000249555.1 2003080..2004021(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain FC1]
ATGGTTCAAGAAATTGCACAAGAAATCATTCGTTCGGCTCGGAAAAAAGGGGCGCAAGACATTTATTTTGTCCCCAAGTT
AGATGCCTATGAGCTTCATATGAGGGTAGGAGACGAGCGCTGTAAAATTGGTAGCTATGATTTTGAAAAGTTTGCAGCCG
TTATCAGTCACTTTAAGTTTGTGGCGGGTATGAATGTGGGAGAAAAAAGACGTAGTCAACTGGGTTCCTGTGATTATGCC
TATGACCAGAAGATGGCGTCTCTACGTTTATCTACTGTAGGCGATTATCGGGGGCATGAGAGTTTGGTTATCCGTTTGTT
GCACGATGAGGAGCAGGACTTGCATTTTTGGTTTCAGGATATTGAAGAATTAGGCAAGCAGTACAGGCAACGGGGACTCT
ATCTTTTTGCTGGTCCGGTTGGGAGTGGTAAGACGACCTTGATGCATGAATTGTCCAAGTCACTCTTTAAAGGACAGCAA
GTTATGTCCATCGAAGATCCTGTCGAAATCAAGCAGGACGACATGCTTCAGTTGCAGTTGAACGAAGCAATCGGCCTAAC
CTATGAAAATCTAATCAAACTTTCCTTGCGTCATCGACCAGATCTCTTGATTATCGGAGAAATTCGTGACAGCGAGACGG
CGCGTGCAGTGGTCAGAGCTAGTTTGACAGGTGCGACAGTCTTTTCAACCATTCACGCCAAGAGTATCCGAGGTGTTTAT
GAGCGTCTGCTGGAGTTGGGTGTGAGTGAAGAAGAATTGGCAGTTGTTCTGCAAGGAGTCTGCTACCAGAGATTAATCGG
GGGAGGAGGAATCGTTGACTTTGCAAACAGAGATTATCAAGAACACCAAGCAGCCAAGTGGAATGAGCAAATTGACCAAC
TTCTTAAAGATGGACATATCACAAGTCTTCAGGCTGAGACGGAAAAAATTAGCTACAGCTAA

Domains

Predicted by InterProScan.

Type II/IV secretion system protein (T2SSE)

(9-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

98.722

100

0.987
  comGA/cglA/cilD Streptococcus pneumoniae D39

98.722

100

0.987
  comGA/cglA/cilD Streptococcus pneumoniae R6

98.722

100

0.987
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

98.722

100

0.987
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

97.125

100

0.971
  comGA Streptococcus gordonii str. Challis substr. CH1

78.065

99.042

0.773
  comGA Streptococcus mutans UA159

66.238

99.361

0.658
  comGA Streptococcus mutans UA140

66.238

99.361

0.658
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

62.903

99.042

0.623
  comGA Lactococcus lactis subsp. cremoris KW2

55.128

99.681

0.55
  comGA Latilactobacillus sakei subsp. sakei 23K

41.912

86.901

0.364