Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGB/cglB   Type   Machinery gene
Locus tag   ACD268_RS10425 Genome accession   NZ_CP168299
Coordinates   2002116..2003132 (-) Length   338 a.a.
NCBI ID   WP_074017570.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain FC1     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1997116..2008132
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACD268_RS10380 (ACD268_10380) - 1997128..1997406 (-) 279 WP_000261154.1 HTH domain-containing protein -
  ACD268_RS10385 (ACD268_10385) - 1997573..1997809 (-) 237 WP_001157069.1 hypothetical protein -
  ACD268_RS10390 (ACD268_10390) - 1998001..1998291 (-) 291 WP_000167802.1 hypothetical protein -
  ACD268_RS10395 (ACD268_10395) - 1998288..1998434 (-) 147 WP_000389580.1 hypothetical protein -
  ACD268_RS10400 (ACD268_10400) - 1998829..1998951 (-) 123 WP_000343850.1 hypothetical protein -
  ACD268_RS10405 (ACD268_10405) - 1999025..1999300 (-) 276 WP_001094380.1 hypothetical protein -
  ACD268_RS10410 (ACD268_10410) - 1999461..2000213 (+) 753 WP_001023158.1 XRE family transcriptional regulator -
  ACD268_RS10415 (ACD268_10415) - 2000215..2000415 (+) 201 WP_000064302.1 hypothetical protein -
  ACD268_RS10420 (ACD268_10420) - 2000589..2002034 (+) 1446 WP_024478469.1 recombinase family protein -
  ACD268_RS10425 (ACD268_10425) comGB/cglB 2002116..2003132 (-) 1017 WP_074017570.1 competence type IV pilus assembly protein ComGB Machinery gene
  ACD268_RS10430 (ACD268_10430) comGA/cglA/cilD 2003080..2004021 (-) 942 WP_000249555.1 competence type IV pilus ATPase ComGA Machinery gene
  ACD268_RS10435 (ACD268_10435) - 2004096..2004461 (-) 366 WP_000286415.1 DUF1033 family protein -
  ACD268_RS10440 (ACD268_10440) - 2004612..2005670 (-) 1059 WP_000649466.1 zinc-dependent alcohol dehydrogenase family protein -
  ACD268_RS10445 (ACD268_10445) nagA 2005833..2006984 (-) 1152 WP_001134457.1 N-acetylglucosamine-6-phosphate deacetylase -

Sequence

Protein


Download         Length: 338 a.a.        Molecular weight: 38482.48 Da        Isoelectric Point: 9.6162

>NTDB_id=935480 ACD268_RS10425 WP_074017570.1 2002116..2003132(-) (comGB/cglB) [Streptococcus pneumoniae strain FC1]
MDISQVFRLRRKKLATAKQKNIITLFNNLFSSGFHLVETISFLDRSSLLDKQCVTQMRTGLSQGKSFSEMMESLGCSSTI
VTQLSLAEVHGNLHLSLGKIEEYLDNLAKVKKKLIEVATYPLILLGFLLLIMLGLRNYLLPQLDSSNIATRIIGNLPQIF
LGMVGLVSVLALLALTFYKRSSKMSVFSILARLPFIGIFVQTYLTAYYAREWGNMISQGMELTQIFQMMQEQGSQLFKEI
GQDLAQTLKNGREFSQTIGTYPFFRKELSLIIEYGEVKSKLGSELEIYAEKTWEAFFTRVNRTMNLVQPLVFIFVALIIV
LLYAAMLMPMYQNMEVNF

Nucleotide


Download         Length: 1017 bp        

>NTDB_id=935480 ACD268_RS10425 WP_074017570.1 2002116..2003132(-) (comGB/cglB) [Streptococcus pneumoniae strain FC1]
ATGGACATATCACAAGTCTTCAGGCTGAGACGGAAAAAATTAGCTACAGCTAAGCAAAAAAATATCATCACCCTATTTAA
CAATCTCTTTTCTAGCGGTTTTCATCTGGTGGAGACTATCTCCTTTTTAGATAGGAGTTCCTTGTTGGACAAGCAGTGTG
TGACCCAGATGCGTACAGGCTTGTCTCAGGGGAAATCATTCTCAGAAATGATGGAAAGTTTGGGATGTTCAAGTACCATT
GTCACTCAGTTATCTCTAGCTGAAGTTCATGGTAATCTCCACCTGAGTTTGGGAAAGATAGAAGAATATCTAGACAATCT
GGCCAAGGTCAAGAAAAAATTGATTGAAGTAGCGACCTATCCTTTGATTTTGCTGGGTTTTCTTCTCTTAATTATGCTGG
GGCTACGGAATTACCTGCTCCCACAACTGGATAGTAGCAATATTGCCACCCGAATTATCGGTAATCTGCCACAAATTTTT
CTAGGCATGGTAGGGCTTGTTTCCGTGCTTGCCCTTTTAGCACTAACTTTTTATAAAAGAAGTTCTAAGATGAGTGTCTT
TTCTATCTTAGCACGCCTTCCCTTTATTGGAATATTTGTGCAGACCTACTTGACAGCCTATTATGCACGTGAATGGGGGA
ATATGATTTCACAGGGAATGGAGCTGACGCAGATTTTTCAAATGATGCAGGAACAAGGTTCCCAGCTCTTTAAAGAAATC
GGTCAAGATCTGGCTCAAACCCTGAAAAATGGCCGTGAATTTTCTCAGACGATAGGAACCTATCCTTTCTTTAGGAAGGA
ATTGAGTCTCATCATAGAGTATGGGGAAGTTAAGTCCAAGCTGGGTAGTGAGTTGGAAATCTATGCTGAAAAAACTTGGG
AAGCCTTTTTTACCCGAGTCAACCGCACCATGAATTTGGTGCAGCCACTGGTTTTTATTTTTGTGGCACTGATTATCGTT
TTACTTTATGCGGCAATGCTCATGCCCATGTATCAAAATATGGAGGTAAATTTTTAA

Domains

Predicted by InterProScan.

Type II secretion system (T2SS), protein F (T2SSF)

(24-141)

Type II secretion system (T2SS), protein F (T2SSF)

(209-329)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGB/cglB Streptococcus pneumoniae Rx1

98.521

100

0.985
  comGB/cglB Streptococcus pneumoniae D39

98.521

100

0.985
  comGB/cglB Streptococcus pneumoniae R6

98.521

100

0.985
  comGB/cglB Streptococcus pneumoniae TIGR4

98.521

100

0.985
  comGB/cglB Streptococcus mitis SK321

94.97

100

0.95
  comGB/cglB Streptococcus mitis NCTC 12261

94.083

100

0.941
  comGB Streptococcus gordonii str. Challis substr. CH1

70.536

99.408

0.701
  comGB Streptococcus mutans UA140

58.176

94.083

0.547
  comGB Streptococcus mutans UA159

58.176

94.083

0.547
  comGB Lactococcus lactis subsp. cremoris KW2

50.898

98.817

0.503