Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   VKP39_RS08205 Genome accession   NZ_CP142353
Coordinates   1665018..1666289 (-) Length   423 a.a.
NCBI ID   WP_002992182.1    Uniprot ID   A0A660A3W1
Organism   Streptococcus pyogenes strain D641     
Function   require for competence (predicted from homology)   
Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1655296..1683670 1665018..1666289 within 0


Gene organization within MGE regions


Location: 1655296..1683670
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VKP39_RS08150 (VKP39_08150) nrdG 1655296..1655910 (-) 615 WP_002982219.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  VKP39_RS08155 (VKP39_08155) - 1655910..1656419 (-) 510 WP_002991345.1 GNAT family N-acetyltransferase -
  VKP39_RS08160 (VKP39_08160) - 1656428..1657363 (-) 936 WP_326623859.1 Gfo/Idh/MocA family oxidoreductase -
  VKP39_RS08165 (VKP39_08165) - 1657392..1657538 (-) 147 WP_002982210.1 hypothetical protein -
  VKP39_RS08170 (VKP39_08170) nrdD 1657720..1659918 (-) 2199 WP_002992831.1 anaerobic ribonucleoside-triphosphate reductase -
  VKP39_RS08175 (VKP39_08175) - 1660015..1661574 (-) 1560 WP_002992833.1 membrane protein -
  VKP39_RS08180 (VKP39_08180) - 1661987..1662292 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  VKP39_RS08185 (VKP39_08185) ruvX 1662304..1662723 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  VKP39_RS08190 (VKP39_08190) - 1662720..1662989 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  VKP39_RS08195 (VKP39_08195) spx 1663104..1663502 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  VKP39_RS08200 (VKP39_08200) recA 1663793..1664929 (-) 1137 WP_002992179.1 recombinase RecA Machinery gene
  VKP39_RS08205 (VKP39_08205) cinA 1665018..1666289 (-) 1272 WP_002992182.1 competence/damage-inducible protein A Machinery gene
  VKP39_RS08210 (VKP39_08210) - 1666358..1666918 (-) 561 WP_002992183.1 DNA-3-methyladenine glycosylase I -
  VKP39_RS08215 (VKP39_08215) ruvA 1666928..1667524 (-) 597 WP_002992186.1 Holliday junction branch migration protein RuvA -
  VKP39_RS08220 (VKP39_08220) - 1667526..1668746 (-) 1221 WP_002992187.1 MDR family MFS transporter -
  VKP39_RS08225 (VKP39_08225) mutL 1668757..1670739 (-) 1983 WP_326623860.1 DNA mismatch repair endonuclease MutL -
  VKP39_RS08230 (VKP39_08230) - 1670834..1671985 (-) 1152 WP_014635780.1 tyrosine-type recombinase/integrase -
  VKP39_RS08235 (VKP39_08235) - 1672234..1672377 (+) 144 WP_011185066.1 putative holin-like toxin -
  VKP39_RS08240 (VKP39_08240) - 1673238..1674005 (-) 768 WP_003058809.1 helix-turn-helix transcriptional regulator -
  VKP39_RS08245 (VKP39_08245) - 1674159..1674365 (+) 207 WP_002992503.1 helix-turn-helix transcriptional regulator -
  VKP39_RS08250 (VKP39_08250) - 1674399..1675166 (+) 768 WP_080277853.1 Bro-N domain-containing protein -
  VKP39_RS08255 (VKP39_08255) - 1675176..1675787 (+) 612 WP_326623861.1 Bro-N domain-containing protein -
  VKP39_RS08260 (VKP39_08260) - 1675807..1676214 (+) 408 WP_136262270.1 hypothetical protein -
  VKP39_RS08265 (VKP39_08265) - 1676227..1676844 (+) 618 WP_326623862.1 Rha family transcriptional regulator -
  VKP39_RS08270 (VKP39_08270) - 1677089..1677421 (+) 333 WP_326623863.1 hypothetical protein -
  VKP39_RS08275 (VKP39_08275) - 1677418..1677558 (+) 141 WP_326623864.1 hypothetical protein -
  VKP39_RS08280 (VKP39_08280) - 1677539..1677736 (+) 198 WP_326623865.1 hypothetical protein -
  VKP39_RS08285 (VKP39_08285) - 1677748..1678077 (+) 330 WP_111681410.1 hypothetical protein -
  VKP39_RS08290 (VKP39_08290) - 1678080..1678352 (+) 273 WP_001100459.1 hypothetical protein -
  VKP39_RS08295 (VKP39_08295) - 1678353..1679210 (+) 858 WP_032463081.1 primase alpha helix C-terminal domain-containing protein -
  VKP39_RS08300 (VKP39_08300) - 1679179..1680867 (+) 1689 WP_326623866.1 phage/plasmid primase, P4 family -
  VKP39_RS08305 (VKP39_08305) - 1681154..1681327 (+) 174 WP_000694577.1 hypothetical protein -
  VKP39_RS08310 (VKP39_08310) - 1681333..1681506 (+) 174 WP_014635784.1 hypothetical protein -
  VKP39_RS08315 (VKP39_08315) - 1681508..1682017 (+) 510 WP_014407945.1 hypothetical protein -
  VKP39_RS08320 (VKP39_08320) - 1682091..1682579 (+) 489 WP_326623867.1 hypothetical protein -
  VKP39_RS08325 (VKP39_08325) - 1682962..1683324 (+) 363 WP_326623868.1 DUF1492 domain-containing protein -
  VKP39_RS08330 (VKP39_08330) - 1683299..1683670 (+) 372 WP_326623869.1 ArpU family phage packaging/lysis transcriptional regulator -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45933.64 Da        Isoelectric Point: 4.7648

>NTDB_id=925186 VKP39_RS08205 WP_002992182.1 1665018..1666289(-) (cinA) [Streptococcus pyogenes strain D641]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRRDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPI
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKSITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
CYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=925186 VKP39_RS08205 WP_002992182.1 1665018..1666289(-) (cinA) [Streptococcus pyogenes strain D641]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGGAGTGATTTGGTCATTTTATGCGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAGAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGATCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATTACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATA
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGTCAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACGGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGTCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
TGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Competence-damaged protein (CinA)

(263-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A660A3W1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.267

100

0.693
  cinA Streptococcus mitis SK321

69.065

98.582

0.681
  cinA Streptococcus mitis NCTC 12261

68.585

98.582

0.676
  cinA Streptococcus pneumoniae TIGR4

67.626

98.582

0.667
  cinA Streptococcus pneumoniae Rx1

67.626

98.582

0.667
  cinA Streptococcus pneumoniae R6

67.626

98.582

0.667
  cinA Streptococcus pneumoniae D39

67.386

98.582

0.664
  cinA Streptococcus suis isolate S10

52.644

98.345

0.518
  cinA Bacillus subtilis subsp. subtilis str. 168

46.172

98.818

0.456