Detailed information NTG0909478

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: SM121_RS02245
• Genome accession: NZ_CP139418
• Coordinates: 427445..428203 (+)
• Length: 252 a.a.
• NCBI ID: WP_151379380.1
• Uniprot ID: -
• Organism: Streptococcus dentalis strain S1
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	419822..428203	427445..428203	within	0

Gene organization within MGE regions

Location: 419822..428203

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SM121_RS02205 (SM121_02205)	-	419822..420013 (-)	192	WP_003002008.1	DUF951 domain-containing protein	-
SM121_RS02210 (SM121_02210)	dnaN	420026..421162 (-)	1137	WP_003010786.1	DNA polymerase III subunit beta	-
SM121_RS02215 (SM121_02215)	dnaA	421322..422680 (-)	1359	WP_003002121.1	chromosomal replication initiator protein DnaA	-
SM121_RS02220 (SM121_02220)	spo0J	422947..423708 (-)	762	WP_320911053.1	ParB/RepB/Spo0J family partition protein	Regulator
SM121_RS02225 (SM121_02225)	htrA	423780..424961 (-)	1182	WP_155172793.1	S1C family serine protease	Regulator
SM121_RS02230 (SM121_02230)	rlmH	425166..425645 (+)	480	WP_003009233.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SM121_RS02240 (SM121_02240)	-	426108..427448 (+)	1341	WP_270300096.1	GHKL domain-containing protein	-
SM121_RS02245 (SM121_02245)	comE/comE2	427445..428203 (+)	759	WP_151379380.1	LytTR family DNA-binding domain-containing protein	Regulator

Sequence

Protein

• Length: 252 a.a.
• Molecular weight: 29678.24 Da
• Isoelectric Point: 5.7562

>NTDB_id=909478 SM121_RS02245 WP_151379380.1 427445..428203(+) (comE/comE2) [Streptococcus dentalis strain S1]
MKIFLLEDELSQQIRVEKHIVEIAKELEIKLEVISTGKLTEFENYIQHSDIHQLYFLDIHIQDNEYCGLEIAKKIRETNP
YAIIVFITTKSEFASITYRYKVSALDFIDKNLNEDLFRLKIKECIEYLTTIQIGNDDLTDYFEYDFKDKKIKIPFKDILY
IETVGSAYKLNLVGKNFQKEIAGSLSDVLEKDVEERYFSPHQSYIVNRSMIVGMDKKRKQLLLKEGYSCPISRSNIKRVK
KLIEEQNLEFSA

Nucleotide

• Length: 759 bp

>NTDB_id=909478 SM121_RS02245 WP_151379380.1 427445..428203(+) (comE/comE2) [Streptococcus dentalis strain S1]
ATGAAGATTTTTTTATTAGAAGATGAGCTCTCTCAACAGATACGGGTAGAAAAACATATTGTAGAAATTGCTAAAGAATT
AGAAATTAAACTTGAAGTGATTTCTACCGGTAAACTTACGGAATTTGAAAATTATATCCAACATTCGGATATCCACCAAT
TATATTTTCTAGATATTCATATCCAAGACAATGAATATTGTGGGCTAGAAATTGCTAAAAAAATACGAGAAACAAATCCT
TATGCCATTATTGTTTTTATTACTACAAAATCAGAATTCGCTTCTATTACCTATCGTTATAAAGTATCTGCCTTGGATTT
TATTGATAAAAATTTGAATGAAGATTTATTTAGATTAAAAATAAAGGAGTGTATTGAGTATTTAACAACTATTCAAATTG
GAAATGATGATTTGACAGATTATTTTGAGTATGACTTTAAAGATAAAAAGATAAAAATTCCATTTAAGGATATTCTTTAT
ATTGAGACTGTTGGTTCGGCTTATAAATTAAACTTAGTTGGGAAAAATTTTCAAAAAGAAATTGCGGGAAGTTTATCAGA
TGTCTTGGAGAAAGATGTGGAGGAGAGATATTTCAGTCCCCATCAATCTTATATCGTAAATAGAAGTATGATCGTTGGGA
TGGATAAGAAAAGAAAACAGTTGTTGTTGAAAGAAGGGTATTCTTGTCCAATCTCAAGAAGCAATATCAAACGTGTCAAA
AAATTAATTGAAGAGCAAAATTTAGAATTTAGTGCTTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (149-243)

• Response regulator receiver domain (Response_reg) (30-120)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus gordonii strain NCTC7865	48.79	98.413	0.48
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	48.79	98.413	0.48
comE	Streptococcus pneumoniae Rx1	46.371	98.413	0.456
comE	Streptococcus pneumoniae D39	46.371	98.413	0.456
comE	Streptococcus pneumoniae R6	46.371	98.413	0.456
comE	Streptococcus pneumoniae TIGR4	46.371	98.413	0.456
comE	Streptococcus mitis SK321	46.371	98.413	0.456
comE	Streptococcus mitis NCTC 12261	46.371	98.413	0.456
comE	Streptococcus infantis strain Atu-4	45.161	98.413	0.444
comE/blpR	Streptococcus mutans UA159	37.652	98.016	0.369