Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   SM121_RS02225 Genome accession   NZ_CP139418
Coordinates   423780..424961 (-) Length   393 a.a.
NCBI ID   WP_155172793.1    Uniprot ID   -
Organism   Streptococcus dentalis strain S1     
Function   repress competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 419822..428203 423780..424961 within 0


Gene organization within MGE regions


Location: 419822..428203
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SM121_RS02205 (SM121_02205) - 419822..420013 (-) 192 WP_003002008.1 DUF951 domain-containing protein -
  SM121_RS02210 (SM121_02210) dnaN 420026..421162 (-) 1137 WP_003010786.1 DNA polymerase III subunit beta -
  SM121_RS02215 (SM121_02215) dnaA 421322..422680 (-) 1359 WP_003002121.1 chromosomal replication initiator protein DnaA -
  SM121_RS02220 (SM121_02220) spo0J 422947..423708 (-) 762 WP_320911053.1 ParB/RepB/Spo0J family partition protein Regulator
  SM121_RS02225 (SM121_02225) htrA 423780..424961 (-) 1182 WP_155172793.1 S1C family serine protease Regulator
  SM121_RS02230 (SM121_02230) rlmH 425166..425645 (+) 480 WP_003009233.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  SM121_RS02240 (SM121_02240) - 426108..427448 (+) 1341 WP_270300096.1 GHKL domain-containing protein -
  SM121_RS02245 (SM121_02245) comE/comE2 427445..428203 (+) 759 WP_151379380.1 LytTR family DNA-binding domain-containing protein Regulator

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41753.89 Da        Isoelectric Point: 5.7870

>NTDB_id=909477 SM121_RS02225 WP_155172793.1 423780..424961(-) (htrA) [Streptococcus dentalis strain S1]
MKSSYNLLKKVGSIALIFVVGFLGGILGTFLTLQTSHSSTSNTESKQVHSTTVKTAYKNTTSTSEAVDKVKNAVVSVITY
SDSSNQGLFEKEENSDSQISSEGSGVIYKKEGKYAYLVTNTHVINGAKKVDILLADGNKVPGEVVGSDIYSDIAVVRISA
DKAKAVAEFGDSNQLTVGETAIAIGSPLGTDYANSVTQGIISSQGRNVKLKADNGQNISTRALQTDAAINPGNSGGPLIN
IQGQVIGITSSKISNNGQTSVEGMGFAIPANDVVNIIKQLEEKGKVVRPALGIQMMDLSNLSTSDLSQLKLPEKISGGVL
VRSTLENMPASDKLQRYDVITKIDDTDIESTADLQSALYSHQINDTIKVTFYRDGKQQTTSIKLTKSTEDLSD

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=909477 SM121_RS02225 WP_155172793.1 423780..424961(-) (htrA) [Streptococcus dentalis strain S1]
ATGAAATCTTCATATAATTTACTAAAAAAAGTTGGAAGCATAGCCCTCATTTTTGTTGTGGGTTTTCTAGGTGGGATTCT
TGGAACCTTTTTAACCTTACAAACATCTCATTCTTCTACTTCAAATACTGAAAGTAAGCAAGTCCACTCAACCACTGTTA
AAACAGCTTATAAAAATACGACCTCAACTAGTGAAGCCGTCGATAAAGTGAAAAATGCTGTTGTTTCTGTAATTACTTAT
TCTGATTCTTCGAATCAAGGATTGTTTGAAAAAGAAGAAAACTCTGACTCACAAATTTCTAGTGAAGGTTCTGGAGTCAT
TTATAAAAAAGAAGGAAAATATGCCTACCTTGTTACCAATACCCATGTCATTAATGGTGCTAAAAAAGTAGATATTCTTT
TAGCAGATGGTAATAAAGTCCCTGGAGAAGTAGTTGGATCAGATATCTATTCTGATATCGCAGTAGTTCGCATTAGTGCG
GATAAAGCAAAGGCAGTAGCTGAATTCGGAGATTCAAACCAATTAACGGTTGGTGAGACTGCGATTGCGATCGGTAGCCC
TCTTGGAACAGATTATGCTAATTCTGTTACCCAAGGGATTATTTCCAGCCAAGGCCGCAATGTGAAATTGAAAGCCGATA
ATGGACAAAATATCTCTACACGTGCCTTACAAACAGATGCAGCCATCAACCCAGGGAATTCTGGAGGTCCATTAATCAAT
ATTCAAGGACAAGTCATTGGAATTACCTCAAGTAAAATTTCAAATAACGGACAAACTTCAGTAGAAGGAATGGGATTTGC
AATTCCTGCAAATGATGTTGTCAATATTATCAAGCAACTAGAAGAAAAAGGAAAAGTGGTTCGACCAGCTCTTGGAATCC
AAATGATGGATTTATCCAATCTTTCAACTTCTGATTTAAGCCAATTAAAACTTCCTGAAAAAATCTCTGGAGGAGTACTG
GTTCGTTCAACACTTGAAAATATGCCTGCTTCAGATAAATTGCAACGCTACGATGTCATCACAAAGATTGATGATACAGA
TATCGAGTCAACTGCAGATTTACAATCTGCCCTTTATTCTCACCAAATCAATGATACGATCAAGGTCACATTCTATCGTG
ATGGAAAACAACAAACAACTTCTATCAAGTTGACAAAATCAACTGAGGATCTAAGCGATTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(289-384)

Trypsin-like peptidase domain (Trypsin_2)

(103-248)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

67.839

100

0.687
  htrA Streptococcus mitis NCTC 12261

63.359

100

0.634
  htrA Streptococcus pneumoniae Rx1

63.359

100

0.634
  htrA Streptococcus pneumoniae D39

63.359

100

0.634
  htrA Streptococcus pneumoniae R6

63.359

100

0.634
  htrA Streptococcus pneumoniae TIGR4

63.359

100

0.634
  htrA Streptococcus mutans UA159

54.026

97.964

0.529