Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   RYQ61_RS03375 Genome accession   NZ_CP136799
Coordinates   645810..647078 (-) Length   422 a.a.
NCBI ID   WP_048785785.1    Uniprot ID   -
Organism   Streptococcus intermedius strain XH2169     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 641531..664363 645810..647078 within 0


Gene organization within MGE regions


Location: 641531..664363
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RYQ61_RS03340 (RYQ61_03340) - 641531..641836 (-) 306 WP_003075274.1 DUF1292 domain-containing protein -
  RYQ61_RS03345 (RYQ61_03345) ruvX 641854..642273 (-) 420 WP_021003313.1 Holliday junction resolvase RuvX -
  RYQ61_RS03350 (RYQ61_03350) - 642273..642539 (-) 267 WP_009569646.1 IreB family regulatory phosphoprotein -
  RYQ61_RS03355 (RYQ61_03355) - 642845..643402 (-) 558 WP_003077293.1 SP0191 family lipoprotein -
  RYQ61_RS03360 (RYQ61_03360) - 643916..644050 (-) 135 WP_257995703.1 hypothetical protein -
  RYQ61_RS03365 (RYQ61_03365) spx 644132..644530 (-) 399 WP_003026638.1 transcriptional regulator Spx -
  RYQ61_RS03370 (RYQ61_03370) recA 644616..645761 (-) 1146 WP_003077215.1 recombinase RecA Machinery gene
  RYQ61_RS03375 (RYQ61_03375) cinA 645810..647078 (-) 1269 WP_048785785.1 competence/damage-inducible protein A Machinery gene
  RYQ61_RS03380 (RYQ61_03380) - 647214..647387 (-) 174 Protein_646 CPBP family intramembrane glutamate endopeptidase -
  RYQ61_RS03385 (RYQ61_03385) - 647392..647946 (-) 555 WP_048785788.1 DNA-3-methyladenine glycosylase I -
  RYQ61_RS03390 (RYQ61_03390) ruvA 647956..648546 (-) 591 WP_048785790.1 Holliday junction branch migration protein RuvA -
  RYQ61_RS03395 (RYQ61_03395) - 648716..649219 (+) 504 WP_048785914.1 helix-turn-helix domain-containing protein -
  RYQ61_RS03400 (RYQ61_03400) - 649203..649712 (+) 510 Protein_650 RDD family protein -
  RYQ61_RS03405 (RYQ61_03405) mutL 649761..651707 (-) 1947 WP_102568435.1 DNA mismatch repair endonuclease MutL -
  RYQ61_RS03410 (RYQ61_03410) - 651826..652974 (-) 1149 WP_070484744.1 site-specific integrase -
  RYQ61_RS03415 (RYQ61_03415) - 653131..654135 (-) 1005 WP_070484742.1 virulence RhuM family protein -
  RYQ61_RS03420 (RYQ61_03420) - 654331..655095 (+) 765 WP_001033569.1 hypothetical protein -
  RYQ61_RS03425 (RYQ61_03425) - 655090..655785 (-) 696 WP_070484740.1 hypothetical protein -
  RYQ61_RS03430 (RYQ61_03430) - 655884..656228 (-) 345 WP_142375095.1 hypothetical protein -
  RYQ61_RS09865 - 656244..656336 (-) 93 Protein_657 helix-turn-helix domain-containing protein -
  RYQ61_RS03440 (RYQ61_03440) - 656589..657248 (-) 660 WP_070484737.1 helix-turn-helix transcriptional regulator -
  RYQ61_RS03445 (RYQ61_03445) - 657409..657612 (+) 204 WP_070484735.1 helix-turn-helix transcriptional regulator -
  RYQ61_RS03450 (RYQ61_03450) - 657626..658243 (+) 618 WP_070484733.1 Rha family transcriptional regulator -
  RYQ61_RS03455 (RYQ61_03455) - 658248..658415 (+) 168 WP_162885573.1 hypothetical protein -
  RYQ61_RS03460 (RYQ61_03460) - 658758..659036 (+) 279 WP_070484731.1 hypothetical protein -
  RYQ61_RS03465 (RYQ61_03465) - 659033..659209 (+) 177 WP_003027795.1 hypothetical protein -
  RYQ61_RS03470 (RYQ61_03470) - 659199..659435 (+) 237 WP_070484729.1 hypothetical protein -
  RYQ61_RS03475 (RYQ61_03475) - 659432..659782 (+) 351 WP_070484727.1 hypothetical protein -
  RYQ61_RS03480 (RYQ61_03480) - 659763..660044 (+) 282 WP_016670425.1 hypothetical protein -
  RYQ61_RS03485 (RYQ61_03485) - 660047..660400 (+) 354 WP_102568419.1 head-tail adaptor protein -
  RYQ61_RS03490 (RYQ61_03490) - 660432..661238 (+) 807 WP_070484723.1 DnaD domain protein -
  RYQ61_RS03495 (RYQ61_03495) - 661254..662081 (+) 828 WP_102568418.1 ATP-binding protein -
  RYQ61_RS03500 (RYQ61_03500) - 662812..663252 (+) 441 WP_102568417.1 ArpU family phage packaging/lysis transcriptional regulator -
  RYQ61_RS03505 (RYQ61_03505) - 663507..663620 (+) 114 Protein_671 phage terminase small subunit P27 family -
  RYQ61_RS03510 (RYQ61_03510) - 663756..663947 (+) 192 WP_049508834.1 type II toxin-antitoxin system HicA family toxin -
  RYQ61_RS03515 (RYQ61_03515) - 663983..664363 (+) 381 WP_102568416.1 type II toxin-antitoxin system HicB family antitoxin -

Sequence

Protein


Download         Length: 422 a.a.        Molecular weight: 45511.04 Da        Isoelectric Point: 6.6649

>NTDB_id=892714 RYQ61_RS03375 WP_048785785.1 645810..647078(-) (cinA) [Streptococcus intermedius strain XH2169]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAGLGVDVYFQTAVGDNEDRLLSILEIARDRSNLVILTGGLGPTEDDLTKQT
LSKFLNRRLVFHQVAVEKLNRFFSSRPDYTRTPNNERQAQIVEGSTPLRNETGLAVGGVVEVSGVTYVVLPGPPSELKPM
VNNELVPLLATGQKLYSRVLRFFGIGESQLVTLLGNLIDTQTDPTIAPYAKTGEVTLRLSTKASSQKEADVKFAHLEKKI
LAVQTFEKQQLADLFYAYGDDNSLGQTAFELLKKAGKTVTAAESLTAGLFQATLANFSGASKVFGGGFVTYGIEEKSQML
GIPLADLEMHGVVSAYTAEKMATQARKLTASDYAVSLTGVAGPDSLEGHPAGTVYIGLATADNVQSIQVNIAGRSRTDVR
KIAVLHAFNLLRKTLLKNENML

Nucleotide


Download         Length: 1269 bp        

>NTDB_id=892714 RYQ61_RS03375 WP_048785785.1 645810..647078(-) (cinA) [Streptococcus intermedius strain XH2169]
ATGAAAGCAGAAATTATTGCTGTGGGTACTGAGATTTTGACTGGTCAGATTGTCAATACGAATGCTCAATTTTTATCTGA
AAAATTAGCGGGCTTGGGAGTAGATGTCTATTTCCAGACAGCGGTTGGAGATAATGAAGATCGTCTGTTATCCATTTTAG
AAATAGCTAGAGATCGTAGTAATTTAGTTATCTTGACAGGTGGTTTAGGTCCGACTGAAGACGACTTAACCAAGCAGACT
TTGTCAAAATTTTTGAATCGTAGGCTAGTCTTTCATCAAGTAGCTGTTGAAAAATTGAATCGTTTCTTCTCCAGCCGACC
GGACTATACTCGAACACCAAATAATGAGCGACAAGCTCAGATAGTAGAAGGGTCGACTCCTCTACGAAATGAAACCGGAC
TTGCAGTTGGTGGCGTTGTTGAAGTCAGTGGTGTGACTTATGTTGTTCTACCTGGCCCCCCTAGTGAACTAAAGCCTATG
GTAAACAATGAGTTGGTTCCGCTTTTAGCAACTGGCCAAAAATTGTATTCGAGAGTCTTGCGTTTCTTTGGTATTGGGGA
GAGTCAATTAGTCACCCTTTTAGGAAACTTGATTGATACTCAGACGGATCCGACCATTGCTCCTTATGCTAAGACGGGAG
AAGTGACGTTGCGATTGTCGACCAAGGCCAGCAGTCAAAAGGAAGCAGATGTTAAGTTTGCTCATCTGGAAAAGAAAATT
TTAGCAGTACAGACTTTTGAGAAACAACAATTAGCCGACCTTTTCTATGCTTATGGAGATGACAATTCTCTGGGACAGAC
AGCTTTTGAATTGTTGAAGAAAGCAGGCAAAACAGTCACAGCAGCTGAAAGTCTGACTGCGGGACTTTTTCAAGCGACTT
TAGCAAATTTTTCTGGAGCATCCAAGGTCTTTGGAGGTGGCTTTGTTACTTATGGCATAGAGGAGAAGAGTCAAATGTTA
GGCATTCCATTGGCAGATTTAGAAATGCATGGGGTAGTCTCAGCTTATACAGCAGAGAAAATGGCTACGCAAGCTAGGAA
ATTGACTGCTAGTGACTATGCAGTGAGTTTGACTGGAGTAGCAGGTCCAGATAGTTTAGAAGGCCATCCAGCAGGAACTG
TTTATATTGGCTTGGCAACTGCAGATAACGTTCAGTCTATTCAGGTTAATATTGCGGGGCGCAGTCGGACGGATGTACGT
AAAATAGCTGTGTTACATGCTTTCAATTTGTTGCGAAAAACTTTATTAAAAAATGAGAATATGCTATAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(263-415)

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mitis SK321

75.12

99.052

0.744
  cinA Streptococcus pneumoniae TIGR4

73.684

99.052

0.73
  cinA Streptococcus mitis NCTC 12261

73.684

99.052

0.73
  cinA Streptococcus pneumoniae Rx1

73.445

99.052

0.727
  cinA Streptococcus pneumoniae R6

73.445

99.052

0.727
  cinA Streptococcus pneumoniae D39

73.206

99.052

0.725
  cinA Streptococcus mutans UA159

70.922

100

0.711
  cinA Streptococcus suis isolate S10

54.087

98.578

0.533
  cinA Bacillus subtilis subsp. subtilis str. 168

46.411

99.052

0.46