Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   RIM74_RS09795 Genome accession   NZ_CP133955
Coordinates   2057129..2058400 (-) Length   423 a.a.
NCBI ID   WP_015898661.1    Uniprot ID   C0MAR7
Organism   Streptococcus equi subsp. equi strain HTP133     
Function   require for competence (predicted from homology)   
Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 2023934..2059942 2057129..2058400 within 0


Gene organization within MGE regions


Location: 2023934..2059942
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RIM74_RS09620 (RIM74_09620) groES 2025480..2025767 (+) 288 WP_012514806.1 co-chaperone GroES -
  RIM74_RS09625 (RIM74_09625) groL 2025835..2027460 (+) 1626 WP_012678897.1 chaperonin GroEL -
  RIM74_RS09630 (RIM74_09630) - 2027614..2028956 (+) 1343 WP_165626751.1 IS3 family transposase -
  RIM74_RS09635 (RIM74_09635) - 2028990..2030165 (+) 1176 WP_317582852.1 YSIRK-targeted surface antigen transcriptional regulator -
  RIM74_RS09640 (RIM74_09640) hslO 2030415..2031287 (+) 873 WP_317582853.1 Hsp33 family molecular chaperone HslO -
  RIM74_RS09645 (RIM74_09645) dusB 2031274..2032251 (+) 978 WP_015898643.1 tRNA dihydrouridine synthase DusB -
  RIM74_RS09650 (RIM74_09650) - 2032272..2032913 (+) 642 Protein_1847 deoxynucleoside kinase -
  RIM74_RS09655 (RIM74_09655) - 2033199..2034203 (+) 1005 WP_015898644.1 hypothetical protein -
  RIM74_RS09660 (RIM74_09660) - 2034302..2035105 (-) 804 WP_015898645.1 ABC transporter ATP-binding protein -
  RIM74_RS09665 (RIM74_09665) - 2035114..2035998 (-) 885 WP_015898646.1 ABC transporter permease -
  RIM74_RS09670 (RIM74_09670) - 2036113..2037075 (-) 963 WP_317582854.1 ABC transporter substrate-binding protein -
  RIM74_RS09675 (RIM74_09675) - 2037093..2038067 (-) 975 WP_015898648.1 ABC transporter substrate-binding protein -
  RIM74_RS09680 (RIM74_09680) ssbA 2038514..2038909 (-) 396 WP_012678670.1 single-stranded DNA-binding protein Machinery gene
  RIM74_RS09685 (RIM74_09685) - 2039021..2039734 (+) 714 WP_015898649.1 bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG -
  RIM74_RS09690 (RIM74_09690) ytpR 2040037..2040663 (-) 627 WP_015898650.1 YtpR family tRNA-binding protein -
  RIM74_RS09695 (RIM74_09695) - 2040678..2040995 (-) 318 WP_015898651.1 thioredoxin family protein -
  RIM74_RS09700 (RIM74_09700) - 2040992..2041276 (-) 285 WP_279526906.1 DUF4651 domain-containing protein -
  RIM74_RS09705 (RIM74_09705) pepA 2041684..2042751 (+) 1068 WP_015898653.1 glutamyl aminopeptidase -
  RIM74_RS09710 (RIM74_09710) proC 2042835..2043608 (+) 774 WP_015898654.1 pyrroline-5-carboxylate reductase -
  RIM74_RS09715 (RIM74_09715) - 2043831..2044268 (-) 438 WP_015898655.1 hypothetical protein -
  RIM74_RS09720 (RIM74_09720) - 2044298..2044972 (-) 675 WP_012678678.1 CPBP family intramembrane glutamic endopeptidase -
  RIM74_RS09725 (RIM74_09725) - 2044982..2045434 (-) 453 WP_317582855.1 DNA-binding protein -
  RIM74_RS09730 (RIM74_09730) - 2045436..2045639 (-) 204 WP_012516427.1 helix-turn-helix transcriptional regulator -
  RIM74_RS09735 (RIM74_09735) yaaA 2046081..2046812 (+) 732 WP_015898656.1 peroxide stress protein YaaA -
  RIM74_RS09740 (RIM74_09740) nrdG 2047270..2047884 (-) 615 WP_012678681.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  RIM74_RS09745 (RIM74_09745) - 2047894..2048388 (-) 495 WP_012516431.1 GNAT family N-acetyltransferase -
  RIM74_RS09750 (RIM74_09750) - 2048401..2049336 (-) 936 WP_317582856.1 Gfo/Idh/MocA family oxidoreductase -
  RIM74_RS09755 (RIM74_09755) - 2049364..2049510 (-) 147 WP_012516433.1 hypothetical protein -
  RIM74_RS09760 (RIM74_09760) nrdD 2049616..2051814 (-) 2199 WP_015898658.1 anaerobic ribonucleoside-triphosphate reductase -
  RIM74_RS09765 (RIM74_09765) - 2051911..2053470 (-) 1560 WP_015898659.1 membrane protein -
  RIM74_RS09770 (RIM74_09770) - 2054018..2054317 (-) 300 WP_012516437.1 DUF1292 domain-containing protein -
  RIM74_RS09775 (RIM74_09775) ruvX 2054327..2054746 (-) 420 WP_015898660.1 Holliday junction resolvase RuvX -
  RIM74_RS09780 (RIM74_09780) - 2054743..2055012 (-) 270 WP_012516439.1 IreB family regulatory phosphoprotein -
  RIM74_RS09785 (RIM74_09785) spx 2055125..2055523 (-) 399 WP_012516440.1 transcriptional regulator Spx -
  RIM74_RS09790 (RIM74_09790) recA 2055899..2057035 (-) 1137 WP_012678688.1 recombinase RecA Machinery gene
  RIM74_RS09795 (RIM74_09795) cinA 2057129..2058400 (-) 1272 WP_015898661.1 competence/damage-inducible protein A Machinery gene
  RIM74_RS09800 (RIM74_09800) - 2059086..2059376 (-) 291 WP_012516443.1 hypothetical protein -
  RIM74_RS09805 (RIM74_09805) - 2059370..2059942 (-) 573 WP_015898662.1 phospholipase A2 SlaB -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45765.45 Da        Isoelectric Point: 6.1706

>NTDB_id=877886 RIM74_RS09795 WP_015898661.1 2057129..2058400(-) (cinA) [Streptococcus equi subsp. equi strain HTP133]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVIDIASQRSDLVILCGGLGPTDDDLTKQT
LAKYLGKALVFDEQAGQKLDAFFAHRKQAARTPNNQRQAQLIEGSIALQNQTGLAVGGLITVDRVTYVVLPGPPSELKPM
VKNELVPLLSASHASLYSRVLRFFGIGESQLVTALEDLIKHQTDPTIAPYAKTGEVTLRLSTKADNQALADERLNRLEAQ
LLSIRTVDNQPLRRLLYGYGEDNSLARETFELLKRSGKTITAAESLTAGLFQAQLTDFAGASQVFNGGFITYSIEEKARM
LGIPLGELQRHGVVSSFTAEQMAAQARCLTNSDIGIGLTGVAGPEALEGQPAGTVFIGLATKNKVESLKVVIGGRSRLDV
RYIAALYAFNMVRKTLLKSENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=877886 RIM74_RS09795 WP_015898661.1 2057129..2058400(-) (cinA) [Streptococcus equi subsp. equi strain HTP133]
ATGAAAGCTGAACTCATTGCGGTGGGAACCGAGATTCTGACTGGTCAGATTGTGAATACCAATGCTCAATTTTTATCAGA
AAAAATGGCGGAGCTTGGTATTGATGTTTATTTTCAAACAGCTGTAGGAGATAATGAAGAGCGTTTGCTTTCTGTTATTG
ATATTGCTAGCCAGCGAAGTGATTTAGTGATTTTATGTGGTGGTCTTGGTCCAACAGATGATGATCTAACGAAGCAGACC
TTAGCTAAGTATCTGGGAAAAGCTTTGGTCTTTGATGAGCAGGCAGGTCAAAAATTAGATGCTTTTTTTGCACATCGTAA
GCAGGCTGCTAGGACACCAAATAACCAACGTCAGGCGCAGCTGATTGAAGGCTCTATTGCTTTGCAAAATCAAACAGGAC
TTGCAGTAGGTGGGTTAATAACTGTAGATAGGGTAACCTATGTTGTCTTACCAGGGCCTCCAAGTGAGCTAAAGCCTATG
GTAAAAAATGAGCTGGTGCCCCTTCTTTCAGCTAGTCATGCCAGTCTATATTCAAGAGTGCTGCGTTTTTTTGGCATTGG
TGAAAGTCAACTGGTGACTGCTCTGGAGGATTTGATTAAGCATCAAACAGATCCTACTATTGCTCCTTATGCAAAGACCG
GCGAGGTAACACTGCGACTATCCACAAAAGCTGACAACCAAGCATTAGCTGATGAAAGGCTGAATCGACTAGAGGCGCAG
CTCTTATCCATAAGAACTGTAGATAATCAACCCTTACGGCGTTTGCTTTATGGCTATGGGGAGGATAATTCCTTGGCGCG
TGAGACCTTTGAGCTATTGAAGCGAAGTGGTAAGACGATAACAGCAGCTGAAAGCTTAACAGCAGGACTGTTTCAAGCTC
AGTTAACTGATTTTGCGGGAGCTTCACAGGTGTTTAACGGTGGCTTTATCACCTACAGCATTGAAGAAAAAGCAAGAATG
CTTGGCATTCCATTGGGTGAGCTACAAAGGCATGGTGTTGTGAGCTCTTTTACAGCTGAGCAAATGGCTGCACAGGCACG
CTGCTTGACCAATTCAGATATCGGTATTGGTCTAACAGGTGTTGCTGGTCCAGAGGCACTCGAGGGACAGCCAGCAGGAA
CAGTTTTCATTGGCCTTGCCACTAAGAATAAGGTAGAATCTCTTAAAGTTGTTATAGGAGGCCGTAGCCGTTTGGACGTG
CGGTATATTGCTGCCCTATATGCTTTTAATATGGTTCGTAAAACTTTATTAAAATCAGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(263-416)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-241)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C0MAR7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

70.686

100

0.707
  cinA Streptococcus mitis NCTC 12261

70.504

98.582

0.695
  cinA Streptococcus mitis SK321

70.264

98.582

0.693
  cinA Streptococcus pneumoniae TIGR4

70.024

98.582

0.69
  cinA Streptococcus pneumoniae Rx1

70.024

98.582

0.69
  cinA Streptococcus pneumoniae R6

70.024

98.582

0.69
  cinA Streptococcus pneumoniae D39

69.784

98.582

0.688
  cinA Streptococcus suis isolate S10

54.177

99.054

0.537
  cinA Bacillus subtilis subsp. subtilis str. 168

47.847

98.818

0.473