Detailed information NTG0874504

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: RDV54_RS07075
• Genome accession: NZ_CP133471
• Coordinates: 1489683..1490435 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866073.1
• Uniprot ID: A0A081S8D7
• Organism: Streptococcus mitis strain LMG 14557
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1484683..1495435

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RDV54_RS07055 (RDV54_07055)	-	1486128..1488770 (-)	2643	WP_000472064.1	YhgE/Pip domain-containing protein	-
RDV54_RS07060 (RDV54_07060)	-	1488898..1489440 (+)	543	WP_001158274.1	TetR/AcrR family transcriptional regulator	-
RDV54_RS07075 (RDV54_07075)	comE	1489683..1490435 (-)	753	WP_000866073.1	competence system response regulator transcription factor ComE	Regulator
RDV54_RS07080 (RDV54_07080)	comD	1490432..1491757 (-)	1326	WP_020902616.1	competence system sensor histidine kinase ComD	Regulator
RDV54_RS07085 (RDV54_07085)	comC	1491770..1491892 (-)	123	WP_004238992.1	competence-stimulating peptide ComC	Regulator
RDV54_RS07095 (RDV54_07095)	rlmH	1492175..1492654 (-)	480	WP_000695934.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
RDV54_RS07100 (RDV54_07100)	htrA	1492837..1494018 (+)	1182	WP_000681587.1	S1C family serine protease	Regulator
RDV54_RS07105 (RDV54_07105)	spo0J	1494076..1494834 (+)	759	WP_000410370.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29947.32 Da
• Isoelectric Point: 6.9819

>NTDB_id=874504 RDV54_RS07075 WP_000866073.1 1489683..1490435(-) (comE) [Streptococcus mitis strain LMG 14557]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=874504 RDV54_RS07075 WP_000866073.1 1489683..1490435(-) (comE) [Streptococcus mitis strain LMG 14557]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAACCAGC
TTTATTTTCTAGATATTGATATTCATGGAATTGAGAAAAAAGGGTTTGAAGTTGCTCAGTTTATTCGTCATCACAATCCT
TACGCTATTATCGTCTTTATCACCAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCTTAGATTT
TGTTGATAAGGATATCAATGATGAGTTGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTTGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACGACAGGTGTCTCTCATAAATTACGCATTATTGGTAAGAATTTTGCCAAAGAGTTTTACGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCATAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTCTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

3D structure

• AlphaFold DB: A0A081S8D7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus pneumoniae Rx1	98.4	100	0.984
comE	Streptococcus pneumoniae D39	98.4	100	0.984
comE	Streptococcus pneumoniae R6	98.4	100	0.984
comE	Streptococcus pneumoniae TIGR4	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	92.8	100	0.928
comE/comE2	Streptococcus gordonii strain NCTC7865	64	100	0.64
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	64	100	0.64
comE/blpR	Streptococcus mutans UA159	41.7	98.8	0.412