Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   U0448_RS07170 Genome accession   NZ_CP139860
Coordinates   1393539..1394171 (+) Length   210 a.a.
NCBI ID   WP_000698434.1    Uniprot ID   Q9S1J7
Organism   Streptococcus pneumoniae strain 21011     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1388539..1399171
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U0448_RS07145 mvaD 1388816..1389769 (+) 954 WP_000373457.1 diphosphomevalonate decarboxylase -
  U0448_RS07150 - 1389756..1390763 (+) 1008 WP_000562442.1 phosphomevalonate kinase -
  U0448_RS07155 fni 1390747..1391757 (+) 1011 WP_000210623.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  U0448_RS07160 liaF 1391835..1392533 (+) 699 WP_001224634.1 cell wall-active antibiotics response protein LiaF -
  U0448_RS07165 - 1392530..1393525 (+) 996 WP_081570894.1 sensor histidine kinase -
  U0448_RS07170 vraR 1393539..1394171 (+) 633 WP_000698434.1 response regulator transcription factor Regulator
  U0448_RS07175 - 1394235..1394932 (+) 698 Protein_1366 DNA alkylation repair protein -
  U0448_RS07180 - 1395082..1395321 (+) 240 WP_000754501.1 hypothetical protein -
  U0448_RS07185 cbpG 1395402..1395992 (+) 591 Protein_1368 choline-binding protein CbpG -
  U0448_RS07190 - 1396294..1396686 (+) 393 WP_000378121.1 tyrosine-type recombinase/integrase -
  U0448_RS07195 tig 1396847..1398130 (+) 1284 WP_044811780.1 trigger factor -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23553.03 Da        Isoelectric Point: 4.5791

>NTDB_id=832115 U0448_RS07170 WP_000698434.1 1393539..1394171(+) (vraR) [Streptococcus pneumoniae strain 21011]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=832115 U0448_RS07170 WP_000698434.1 1393539..1394171(+) (vraR) [Streptococcus pneumoniae strain 21011]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGATTGGGTTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGGATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGACGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAATATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGGCTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1J7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41