Detailed information NTG0830866

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: QL280_RS10400
• Genome accession: NZ_CP125291
• Coordinates: 2031406..2032158 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 105_Kz
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2026406..2037158

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QL280_RS10380 (QL280_10380)	-	2028861..2030493 (-)	1633	Protein_2012	YhgE/Pip domain-containing protein	-
QL280_RS10385 (QL280_10385)	-	2030621..2031163 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
QL280_RS10400 (QL280_10400)	comE	2031406..2032158 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
QL280_RS10405 (QL280_10405)	comD/comD1	2032155..2033480 (-)	1326	WP_001813456.1	competence system sensor histidine kinase ComD	Regulator
QL280_RS10410 (QL280_10410)	comC/comC1	2033501..2033626 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
QL280_RS10420 (QL280_10420)	rlmH	2033908..2034387 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
QL280_RS10425 (QL280_10425)	htrA	2034570..2035751 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
QL280_RS10430 (QL280_10430)	spo0J	2035809..2036567 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=830866 QL280_RS10400 WP_000866065.1 2031406..2032158(-) (comE) [Streptococcus pneumoniae strain 105_Kz]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=830866 QL280_RS10400 WP_000866065.1 2031406..2032158(-) (comE) [Streptococcus pneumoniae strain 105_Kz]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408