Detailed information NTG0830869

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: QL280_RS10425
• Genome accession: NZ_CP125291
• Coordinates: 2034570..2035751 (+)
• Length: 393 a.a.
• NCBI ID: WP_000681601.1
• Uniprot ID: A0A0B7LRW6
• Organism: Streptococcus pneumoniae strain 105_Kz
• Function: degrading CSP; selective degradation of ComEA and ComEC (predicted from homology) Competence regulation

Genomic Context

Location: 2029570..2040751

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QL280_RS10385 (QL280_10385)	-	2030621..2031163 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
QL280_RS10400 (QL280_10400)	comE	2031406..2032158 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
QL280_RS10405 (QL280_10405)	comD/comD1	2032155..2033480 (-)	1326	WP_001813456.1	competence system sensor histidine kinase ComD	Regulator
QL280_RS10410 (QL280_10410)	comC/comC1	2033501..2033626 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
QL280_RS10420 (QL280_10420)	rlmH	2033908..2034387 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
QL280_RS10425 (QL280_10425)	htrA	2034570..2035751 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
QL280_RS10430 (QL280_10430)	spo0J	2035809..2036567 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41855.70 Da
• Isoelectric Point: 6.8902

>NTDB_id=830869 QL280_RS10425 WP_000681601.1 2034570..2035751(+) (htrA) [Streptococcus pneumoniae strain 105_Kz]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLRSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=830869 QL280_RS10425 WP_000681601.1 2034570..2035751(+) (htrA) [Streptococcus pneumoniae strain 105_Kz]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTAGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAGATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTGA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (289-384)

3D structure

• AlphaFold DB: A0A0B7LRW6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus pneumoniae Rx1	99.491	100	0.995
htrA	Streptococcus pneumoniae D39	99.491	100	0.995
htrA	Streptococcus pneumoniae R6	99.491	100	0.995
htrA	Streptococcus pneumoniae TIGR4	99.491	100	0.995
htrA	Streptococcus mitis NCTC 12261	97.201	100	0.972
htrA	Streptococcus gordonii str. Challis substr. CH1	66.919	100	0.674
htrA	Streptococcus mutans UA159	54.822	100	0.55