Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   H7675_RS08920 Genome accession   NZ_AP023389
Coordinates   1784451..1785722 (-) Length   423 a.a.
NCBI ID   WP_184004729.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain KUN-0012590     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 1779451..1790722
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7675_RS08895 (KUN2590_17100) - 1781420..1781725 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  H7675_RS08900 (KUN2590_17110) ruvX 1781737..1782156 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  H7675_RS08905 (KUN2590_17120) - 1782153..1782422 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  H7675_RS08910 (KUN2590_17130) spx 1782537..1782935 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  H7675_RS08915 (KUN2590_17140) recA 1783226..1784362 (-) 1137 WP_184004726.1 recombinase RecA Machinery gene
  H7675_RS08920 (KUN2590_17150) cinA 1784451..1785722 (-) 1272 WP_184004729.1 competence/damage-inducible protein A Machinery gene
  H7675_RS08925 (KUN2590_17160) - 1785791..1786351 (-) 561 WP_023079151.1 DNA-3-methyladenine glycosylase I -
  H7675_RS08930 (KUN2590_17170) ruvA 1786361..1786957 (-) 597 WP_031488763.1 Holliday junction branch migration protein RuvA -
  H7675_RS08935 (KUN2590_17180) - 1786959..1788179 (-) 1221 WP_136285989.1 MDR family MFS transporter -
  H7675_RS08940 (KUN2590_17190) mutL 1788190..1790172 (-) 1983 WP_184004732.1 DNA mismatch repair endonuclease MutL -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45959.72 Da        Isoelectric Point: 4.9007

>NTDB_id=82811 H7675_RS08920 WP_184004729.1 1784451..1785722(-) (cinA) [Streptococcus pyogenes strain KUN-0012590]
MKAELIAVGTEILTGQIVNANAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSNLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=82811 H7675_RS08920 WP_184004729.1 1784451..1785722(-) (cinA) [Streptococcus pyogenes strain KUN-0012590]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATGCCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTAACTTGGTAATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACGGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGTCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(263-416)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.267

100

0.693
  cinA Streptococcus mitis SK321

69.784

98.582

0.688
  cinA Streptococcus mitis NCTC 12261

69.305

98.582

0.683
  cinA Streptococcus pneumoniae TIGR4

68.345

98.582

0.674
  cinA Streptococcus pneumoniae Rx1

68.345

98.582

0.674
  cinA Streptococcus pneumoniae R6

68.345

98.582

0.674
  cinA Streptococcus pneumoniae D39

68.106

98.582

0.671
  cinA Streptococcus suis isolate S10

53.125

98.345

0.522
  cinA Bacillus subtilis subsp. subtilis str. 168

46.172

98.818

0.456

Multiple sequence alignment