Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYA   Type   Machinery gene
Locus tag   H7675_RS00650 Genome accession   NZ_AP023389
Coordinates   101673..102611 (+) Length   312 a.a.
NCBI ID   WP_184004775.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain KUN-0012590     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 96673..107611
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7675_RS00640 (KUN2590_00800) rpoC 97422..101063 (+) 3642 WP_063510175.1 DNA-directed RNA polymerase subunit beta' -
  H7675_RS00645 (KUN2590_00810) - 101215..101580 (+) 366 WP_002986560.1 DUF1033 family protein -
  H7675_RS00650 (KUN2590_00820) comYA 101673..102611 (+) 939 WP_184004775.1 competence type IV pilus ATPase ComGA Machinery gene
  H7675_RS00655 (KUN2590_00830) comYB 102547..103581 (+) 1035 WP_232087598.1 competence type IV pilus assembly protein ComGB Machinery gene
  H7675_RS00660 (KUN2590_00840) comYC 103583..103909 (+) 327 WP_002986552.1 competence type IV pilus major pilin ComGC Machinery gene
  H7675_RS00665 (KUN2590_00850) comGD 103884..104312 (+) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD -
  H7675_RS00670 (KUN2590_00860) comGE 104269..104553 (+) 285 WP_011284422.1 competence type IV pilus minor pilin ComGE -
  H7675_RS00675 (KUN2590_00870) comYF 104546..104980 (+) 435 WP_111711329.1 competence type IV pilus minor pilin ComGF Machinery gene
  H7675_RS00680 (KUN2590_00880) comGG 104964..105290 (+) 327 WP_010921801.1 competence type IV pilus minor pilin ComGG -
  H7675_RS00685 (KUN2590_00890) comYH 105388..106341 (+) 954 WP_010921802.1 class I SAM-dependent methyltransferase Machinery gene
  H7675_RS00690 (KUN2590_00900) - 106400..107596 (+) 1197 WP_111711330.1 acetate kinase -

Sequence

Protein


Download         Length: 312 a.a.        Molecular weight: 35036.26 Da        Isoelectric Point: 8.5773

>NTDB_id=82763 H7675_RS00650 WP_184004775.1 101673..102611(+) (comYA) [Streptococcus pyogenes strain KUN-0012590]
MVQALAKAILAKAEQVQAQDIYILPRADQYDLFLRIGDERRLVDVYQSDRMAPLVSHFKFVAGMIVGEKRRCQVGSCDYK
LSKDKQLSLRLSSVGDYRGQESLVIRLLHHQNKSVHYWFDGLTKVANQVGGRGLYLFAGPVGSGKTTLMYQLISNYHQEA
QVISIEDPVEIKNHQILQLQVNDDIGMTYDNLIKLSLRHRPDILVIGEIRDSQTARAVIRASLTGAMVFSTVQAKSISGV
YARLLELGVTKAELSNCLALIAYQRLLNGGALIDSTQNEFEYYSSSNWNQQIDQLLEAGHLNPKQAKLEKII

Nucleotide


Download         Length: 939 bp        

>NTDB_id=82763 H7675_RS00650 WP_184004775.1 101673..102611(+) (comYA) [Streptococcus pyogenes strain KUN-0012590]
ATGGTACAAGCATTAGCAAAAGCTATTCTAGCAAAAGCTGAACAGGTTCAGGCACAAGATATTTATATTTTGCCAAGAGC
AGATCAATATGATCTTTTTTTACGAATAGGAGATGAAAGGAGATTAGTTGATGTTTATCAGAGCGATCGGATGGCTCCTC
TTGTTAGTCACTTTAAATTCGTTGCAGGAATGATAGTTGGTGAAAAGAGACGTTGTCAGGTGGGTTCATGTGATTATAAG
CTCAGTAAAGATAAGCAGTTATCTTTGCGCTTATCTAGCGTGGGTGATTATCGCGGGCAAGAAAGCTTAGTGATTCGTCT
GCTTCATCATCAAAATAAAAGTGTACATTATTGGTTTGATGGATTGACAAAAGTAGCCAATCAGGTTGGCGGTAGAGGGT
TGTATTTATTTGCAGGACCAGTTGGGTCTGGGAAGACAACCTTGATGTACCAGCTGATTTCGAATTATCATCAAGAAGCA
CAGGTTATTAGTATAGAAGATCCTGTAGAAATTAAAAATCACCAGATTTTACAATTACAAGTGAATGATGATATTGGTAT
GACTTATGACAATTTGATCAAACTGTCTTTACGCCATCGACCAGATATTTTAGTTATTGGTGAGATTCGAGATAGTCAAA
CAGCAAGAGCCGTTATTAGGGCTAGTCTAACAGGTGCCATGGTTTTTTCAACGGTTCAGGCTAAAAGTATCTCGGGTGTT
TATGCAAGATTGTTAGAACTTGGTGTAACGAAAGCAGAACTGTCTAATTGCTTAGCATTAATTGCTTACCAAAGGTTACT
TAATGGAGGAGCATTGATTGACTCTACTCAAAACGAATTTGAATATTATTCCTCATCGAACTGGAATCAACAAATTGATC
AGCTTCTTGAGGCAGGACATCTCAATCCCAAGCAAGCTAAGCTTGAAAAAATTATCTAG

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-267)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYA Streptococcus mutans UA140

61.093

99.679

0.609
  comYA Streptococcus mutans UA159

61.093

99.679

0.609
  comYA Streptococcus gordonii str. Challis substr. CH1

60.129

99.679

0.599
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

60

99.359

0.596
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

58.842

99.679

0.587
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

58.199

99.679

0.58
  comGA/cglA/cilD Streptococcus pneumoniae D39

58.199

99.679

0.58
  comGA/cglA/cilD Streptococcus pneumoniae R6

58.199

99.679

0.58
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

58.199

99.679

0.58
  comGA Lactococcus lactis subsp. cremoris KW2

50.161

99.679

0.5
  comGA Latilactobacillus sakei subsp. sakei 23K

39.31

92.949

0.365

Multiple sequence alignment