Detailed information NTG0816604

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: R3H61_RS01215
• Genome accession: NZ_CP136951
• Coordinates: 221303..222043 (+)
• Length: 246 a.a.
• NCBI ID: WP_002986100.1
• Uniprot ID: A0A0H2UT50
• Organism: Streptococcus pyogenes strain Spyo09
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 216303..227043

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R3H61_RS01200 (R3H61_01200)	-	217381..218571 (-)	1191	WP_002299749.1	IS256-like element ISLgar5 family transposase	-
R3H61_RS01205 (R3H61_01205)	-	218673..220019 (+)	1347	WP_023610780.1	sensor histidine kinase	-
R3H61_RS01210 (R3H61_01210)	-	220016..221299 (+)	1284	WP_010921869.1	sensor histidine kinase	-
R3H61_RS01215 (R3H61_01215)	comE/blpR	221303..222043 (+)	741	WP_002986100.1	response regulator transcription factor	Regulator
R3H61_RS01220 (R3H61_01220)	rnpA	222583..222942 (+)	360	WP_002992035.1	ribonuclease P protein component	-
R3H61_RS01225 (R3H61_01225)	-	222908..223735 (+)	828	WP_011528223.1	YidC/Oxa1 family membrane protein insertase	-
R3H61_RS01230 (R3H61_01230)	jag	223747..224661 (+)	915	WP_129284436.1	RNA-binding cell elongation regulator Jag/EloR	-
R3H61_RS01235 (R3H61_01235)	rpmH	224976..225110 (+)	135	WP_002885866.1	50S ribosomal protein L34	-
R3H61_RS01240 (R3H61_01240)	-	225384..226088 (+)	705	WP_129284437.1	N-acetylmannosamine-6-phosphate 2-epimerase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28881.47 Da
• Isoelectric Point: 6.4841

>NTDB_id=816604 R3H61_RS01215 WP_002986100.1 221303..222043(+) (comE/blpR) [Streptococcus pyogenes strain Spyo09]
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQERGDHQLYFLDIEIGEYTRCGLELAAAIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFE
RWEALR

Nucleotide

• Length: 741 bp

>NTDB_id=816604 R3H61_RS01215 WP_002986100.1 221303..222043(+) (comE/blpR) [Streptococcus pyogenes strain Spyo09]
ATGATGAACATTTTTATTCTTGAGGATGATTTTATCCAGCAGACACGCATAGAATCTATCGTAGTAGGCATCTTAAAAGA
GACTAGAATACCATGTAATCAGCTTGAAGTGTTCTCGACTCCTCAAAAATTATTTGAGAGTATCCAAGAAAGAGGAGACC
ATCAGCTGTATTTTTTAGATATTGAAATTGGTGAATATACTCGTTGTGGGCTTGAATTAGCTGCAGCTATTCGACAAAAA
GATCCTAATGCCGTTATTGTGTTTGTCACCACTCATTCAGAATTTGCTCCTATTTCTTTTAAATATAAGGTATCCGCTCT
AGATTTTATTGATAAAGCAGGTGGTCAAAAACAGTTTAAAGAACAAATCGAAGAATGTATCCGATATACTTACGATATGA
TGTCTAGTCGTGAGTCAAAGGACATGTTTTTATTTGAGACTCCACAGACAAGATTAAAATTGCCCTATAAGGATATTTTA
TACTTTGCTACAGCCACAACTCCTCACAAAGTTTGTTTATGGACTCAGACAGAAAGATTAGAGTTTTATGGTAATCTATC
TGAGATTCAAGCAGTAGCACCGAAACTTTTTTTGTGCCATAGATCCTACCTTGTGAATCTAGATAAGGTTGTTCGAATCG
ATAAGAGTAAGCAGCTCCTTTATTTCGAAAATGGTGATTCTTGTATGGTATCACGATTAAAAATGAAATGTCTGTTTGAA
CGGTGGGAGGCTCTTCGCTAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-123)

3D structure

• AlphaFold DB: A0A0H2UT50

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	46.862	97.154	0.455
comE/comE1	Streptococcus equinus JB1	41.597	96.748	0.402
comE/comE2	Streptococcus equinus JB1	39.431	100	0.394
comE	Streptococcus pneumoniae Rx1	38.525	99.187	0.382
comE	Streptococcus pneumoniae D39	38.525	99.187	0.382
comE	Streptococcus pneumoniae R6	38.525	99.187	0.382
comE	Streptococcus pneumoniae TIGR4	38.525	99.187	0.382
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.903	100	0.382
comE/comE2	Streptococcus gordonii strain NCTC7865	37.903	100	0.382
comE	Streptococcus mitis NCTC 12261	37.759	97.967	0.37
comE	Streptococcus mitis SK321	37.759	97.967	0.37