Detailed information NTG0812245

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: P8P68_RS07160
• Genome accession: NZ_CP121467
• Coordinates: 1459180..1459932 (+)
• Length: 250 a.a.
• NCBI ID: WP_000866079.1
• Uniprot ID: A0A081R422
• Organism: Streptococcus sp. D7B5
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	1457864..1466067	1459180..1459932	within	0

Gene organization within MGE regions

Location: 1457864..1466067

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
P8P68_RS07155 (P8P68_07155)	comD	1457864..1459183 (+)	1320	WP_049490808.1	competence system sensor histidine kinase ComD	Regulator
P8P68_RS07160 (P8P68_07160)	comE	1459180..1459932 (+)	753	WP_000866079.1	competence system response regulator transcription factor ComE	Regulator
P8P68_RS07175 (P8P68_07175)	-	1460168..1460710 (-)	543	WP_049477913.1	TetR-like C-terminal domain-containing protein	-
P8P68_RS07180 (P8P68_07180)	-	1460839..1463493 (+)	2655	WP_278275813.1	YhgE/Pip domain-containing protein	-
P8P68_RS07185 (P8P68_07185)	-	1463515..1466067 (-)	2553	WP_000834499.1	YfhO family protein	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29884.23 Da
• Isoelectric Point: 6.9755

>NTDB_id=812245 P8P68_RS07160 WP_000866079.1 1459180..1459932(+) (comE) [Streptococcus sp. D7B5]
MKVLILEDVIEHQVRLERILNEISEESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYCSHKSFLVNVGNVREIDRKNLEVVFYEDHRCPITRLKVRKL
KDILEKKSKK

Nucleotide

• Length: 753 bp

>NTDB_id=812245 P8P68_RS07160 WP_000866079.1 1459180..1459932(+) (comE) [Streptococcus sp. D7B5]
ATGAAAGTATTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTAAATGAAATCTCGGAAGAATC
GAATATTCCTATTTCATATAAGACAACAGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAACCAAC
TTTATTTCCTAGATATCGATATTCATGGAATCGAGAAAAAAGGCTTTGAAGTGGCTCAATTTATCCGTCATCACAATCCT
TATGCTATTATTGTCTTTATTACTAGTCGATCTGAATTTGCTACCTTAACGTACAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAAGATATCAATGATGAATTGTTCAAAAAACGCATTGAGCAGAGTATTTTTTACACTAAGAGCATGCTGCTTG
AAAACGAAGATGTTGTAGACTATTTTGATTACAACTATAAAGGAAATGATTTGAAAATTCCTTACCATGACATTTTGTAT
ATCGAAACCACAGGAGTTTCTCATAAACTTCGGATTATTGGTAAGAATTTTGCAAAAGAATTCTATGGAACTATGACAGA
TATTCAGGAAAAGGACAAACATACCCAGCGATTTTATTGCTCCCATAAATCTTTCCTTGTCAATGTGGGAAATGTGAGAG
AAATTGATCGAAAGAATTTAGAAGTTGTCTTTTATGAAGATCATCGTTGTCCAATTACTCGTTTAAAAGTCCGCAAACTA
AAAGATATTCTAGAGAAAAAATCTAAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

3D structure

• AlphaFold DB: A0A081R422

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	95.6	100	0.956
comE	Streptococcus mitis SK321	94.8	100	0.948
comE	Streptococcus pneumoniae Rx1	94	100	0.94
comE	Streptococcus pneumoniae D39	94	100	0.94
comE	Streptococcus pneumoniae R6	94	100	0.94
comE	Streptococcus pneumoniae TIGR4	94	100	0.94
comE	Streptococcus infantis strain Atu-4	93.6	100	0.936
comE/comE2	Streptococcus gordonii strain NCTC7865	63.2	100	0.632
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	63.2	100	0.632
comE/blpR	Streptococcus mutans UA159	40.486	98.8	0.4