Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD   Type   Regulator
Locus tag   P8P68_RS07155 Genome accession   NZ_CP121467
Coordinates   1457864..1459183 (+) Length   439 a.a.
NCBI ID   WP_049490808.1    Uniprot ID   A0AAX3TH88
Organism   Streptococcus sp. D7B5     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1457864..1466067 1457864..1459183 within 0


Gene organization within MGE regions


Location: 1457864..1466067
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P8P68_RS07155 (P8P68_07155) comD 1457864..1459183 (+) 1320 WP_049490808.1 competence system sensor histidine kinase ComD Regulator
  P8P68_RS07160 (P8P68_07160) comE 1459180..1459932 (+) 753 WP_000866079.1 competence system response regulator transcription factor ComE Regulator
  P8P68_RS07175 (P8P68_07175) - 1460168..1460710 (-) 543 WP_049477913.1 TetR-like C-terminal domain-containing protein -
  P8P68_RS07180 (P8P68_07180) - 1460839..1463493 (+) 2655 WP_278275813.1 YhgE/Pip domain-containing protein -
  P8P68_RS07185 (P8P68_07185) - 1463515..1466067 (-) 2553 WP_000834499.1 YfhO family protein -

Sequence

Protein


Download         Length: 439 a.a.        Molecular weight: 51229.23 Da        Isoelectric Point: 7.0077

>NTDB_id=812244 P8P68_RS07155 WP_049490808.1 1457864..1459183(+) (comD) [Streptococcus sp. D7B5]
MDLFGLGIAIFYFLIISKSYEWICKINRKEQIVFFCYTCISVFILEEIITLVFSNSFALSKFLFPLVVYLYLRKLKKSEK
YKAIFISLLLSLLYHSTHTFISVTLSSITGDEVVLHYKSTFLLVVLLMTYFSILIIIRYFHLDIKYFDKDYLYPFLKKVI
VAFFGLHILLFISDIVSTTHHLNSFGSILSTIVFICLLLIFFAMNSHKVQIEKEIALKQKKFEQKHLQTYTDEIVELYNE
IRGFRHDYAGMLVSMQMAIDSGDLQEINRVYNEVLVKANQKLRSEKYTYFDLNNIEDSALRSLIAQSIVYARKNDVEFTL
EVKDIITRLSIDLLDLVRIMSILLNNAVEGAADSYLKQMEVAVIKMDFETVIVIQNSCKITMTPSEDLFALGFSTKGRNR
GLGLNNVKEILDKYDNIILETEMEDNTFRQIIRFKREFE

Nucleotide


Download         Length: 1320 bp        

>NTDB_id=812244 P8P68_RS07155 WP_049490808.1 1457864..1459183(+) (comD) [Streptococcus sp. D7B5]
ATGGATTTATTTGGATTAGGGATAGCTATTTTTTATTTTCTCATCATTAGCAAAAGTTATGAATGGATTTGTAAAATAAA
TAGAAAAGAACAAATTGTTTTTTTCTGTTACACATGTATCTCAGTTTTTATACTTGAAGAAATTATTACACTAGTATTTT
CTAATAGTTTTGCTTTGTCTAAATTTTTATTTCCTTTGGTTGTGTACCTTTATTTAAGAAAGTTAAAGAAGTCTGAAAAA
TACAAAGCTATTTTTATCAGTTTACTACTGTCTTTATTATATCACAGTACTCATACTTTTATATCCGTAACCTTATCTTC
TATAACAGGAGATGAAGTAGTATTACATTATAAAAGTACATTTCTTTTAGTAGTATTGTTGATGACTTATTTTTCTATTC
TAATAATAATTCGTTATTTTCATCTGGATATTAAATATTTTGATAAAGATTATCTGTATCCTTTTTTAAAAAAAGTAATA
GTTGCTTTCTTTGGTTTGCATATCTTATTATTTATTTCAGATATAGTAAGTACAACTCATCATTTAAATAGTTTCGGAAG
TATTTTATCAACCATTGTTTTTATTTGCTTGTTATTGATTTTCTTTGCAATGAATTCTCACAAGGTTCAAATTGAAAAAG
AGATTGCTCTAAAACAAAAGAAATTTGAACAAAAGCATTTACAGACTTATACTGATGAAATTGTGGAGTTGTATAATGAA
ATTCGAGGTTTTCGTCATGACTATGCAGGGATGCTTGTCAGCATGCAAATGGCGATTGACAGTGGTGATTTACAAGAAAT
TAACAGGGTTTACAATGAAGTCCTAGTAAAAGCAAATCAGAAATTGAGGTCAGAAAAATATACTTACTTTGATTTAAATA
ATATAGAAGACTCTGCTTTACGGAGTTTAATTGCTCAATCGATTGTCTATGCACGAAAAAATGATGTAGAGTTTACATTG
GAAGTAAAGGATATCATTACTAGACTGTCAATAGATTTACTTGATCTTGTTCGTATCATGAGCATTTTATTAAACAATGC
CGTTGAAGGTGCTGCAGATAGTTACTTGAAACAAATGGAAGTTGCAGTCATTAAAATGGATTTTGAAACAGTTATAGTTA
TCCAGAATTCATGCAAAATCACTATGACGCCTTCAGAGGATCTATTTGCCTTAGGTTTTTCTACCAAGGGAAGAAATAGA
GGTTTAGGACTTAATAATGTCAAAGAGATTTTAGATAAGTATGACAACATTATTTTAGAAACAGAGATGGAAGACAACAC
ATTTAGACAAATTATTAGATTTAAGAGGGAATTCGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(333-432)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD Streptococcus mitis SK321

75.283

100

0.756
  comD/comD2 Streptococcus pneumoniae TIGR4

74.376

100

0.747
  comD Streptococcus mitis NCTC 12261

74.376

100

0.747
  comD/comD1 Streptococcus pneumoniae R6

73.923

100

0.743
  comD/comD1 Streptococcus pneumoniae Rx1

73.923

100

0.743
  comD/comD1 Streptococcus pneumoniae D39

73.923

100

0.743
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.733

85.194

0.424
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.202

85.649

0.421