Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   P8P68_RS07135 Genome accession   NZ_CP121467
Coordinates   1455575..1456771 (-) Length   398 a.a.
NCBI ID   WP_042903085.1    Uniprot ID   A0A081R426
Organism   Streptococcus sp. D7B5     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1450575..1461771
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P8P68_RS07115 (P8P68_07115) - 1451627..1451821 (-) 195 WP_000285184.1 DUF951 family protein -
  P8P68_RS07120 (P8P68_07120) dnaN 1451886..1453022 (-) 1137 WP_000581146.1 DNA polymerase III subunit beta -
  P8P68_RS07125 (P8P68_07125) dnaA 1453181..1454542 (-) 1362 WP_000660625.1 chromosomal replication initiator protein DnaA -
  P8P68_RS07130 (P8P68_07130) spo0J 1454759..1455517 (-) 759 WP_049478005.1 ParB/RepB/Spo0J family partition protein Regulator
  P8P68_RS07135 (P8P68_07135) htrA 1455575..1456771 (-) 1197 WP_042903085.1 S1C family serine protease Regulator
  P8P68_RS07140 (P8P68_07140) rlmH 1456957..1457436 (+) 480 WP_042903084.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  P8P68_RS07150 (P8P68_07150) comC/comC2 1457718..1457843 (+) 126 WP_000799678.1 competence-stimulating peptide ComC Regulator
  P8P68_RS07155 (P8P68_07155) comD 1457864..1459183 (+) 1320 WP_049490808.1 competence system sensor histidine kinase ComD Regulator
  P8P68_RS07160 (P8P68_07160) comE 1459180..1459932 (+) 753 WP_000866079.1 competence system response regulator transcription factor ComE Regulator
  P8P68_RS07175 (P8P68_07175) - 1460168..1460710 (-) 543 WP_049477913.1 TetR-like C-terminal domain-containing protein -

Sequence

Protein


Download         Length: 398 a.a.        Molecular weight: 42041.87 Da        Isoelectric Point: 6.6581

>NTDB_id=812242 P8P68_RS07135 WP_042903085.1 1455575..1456771(-) (htrA) [Streptococcus sp. D7B5]
MKHLQKFYKKGVKVLIIILIGFLSGALGSFVTLQLYQKQGNQATNNNSGTVTQTSYKNENSTTQAVNKVKDAVVSIITYS
SSSSRQSSVFNADETNSDSDNQQIASEGSGVIYKKDDKDAYLVTNTHVINGASKVDIRLADGTKVPGEIVGSDTFSDIAV
VKISSEKVTTVAEFGDSSQLSVGETAIAIGSPLGSEYANTVTQGIISSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSG
GPLVNIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDAQNIIKQLESNGKVTRPALGIQMVNLSNVGASDLRKLNIPSGL
TSGVVVRSVQNNMPANGHLQKYDVITKVDDKEIASSTDLQHALYNHAIGDTIKVTYYRNGKEETTSIKLDKNSSDLES

Nucleotide


Download         Length: 1197 bp        

>NTDB_id=812242 P8P68_RS07135 WP_042903085.1 1455575..1456771(-) (htrA) [Streptococcus sp. D7B5]
ATGAAACACTTACAAAAATTTTACAAAAAAGGAGTTAAAGTTCTAATAATCATTCTAATCGGATTTTTAAGTGGTGCCTT
AGGAAGTTTCGTAACATTACAACTTTATCAAAAACAAGGAAATCAAGCTACAAATAATAATTCTGGCACTGTCACTCAAA
CATCCTATAAGAATGAAAATTCAACCACTCAAGCAGTAAATAAAGTTAAGGATGCTGTTGTCTCAATCATTACTTATTCT
TCTTCTAGCAGTAGACAAAGTAGTGTATTTAATGCTGACGAAACTAATTCTGATTCAGACAATCAACAAATCGCAAGTGA
GGGATCAGGTGTTATCTATAAAAAGGATGATAAAGATGCCTATCTTGTAACTAATACTCACGTTATCAATGGAGCTTCAA
AAGTTGATATCCGCTTAGCAGATGGTACCAAGGTTCCTGGTGAAATTGTCGGATCTGATACCTTCTCTGATATTGCTGTC
GTTAAAATTTCTTCCGAAAAAGTTACAACAGTCGCAGAATTTGGAGATTCAAGTCAACTTAGTGTTGGAGAAACAGCGAT
TGCTATTGGTAGTCCTTTAGGTTCAGAATATGCCAATACAGTTACACAGGGGATTATTTCAAGTCTTAATCGAAATGTTT
CTCTAAAATCTGAAGATGGTCAAGCTATTTCAACAAAAGCCATTCAAACAGATACAGCCATTAACCCTGGTAACTCTGGT
GGTCCACTTGTAAACATTCAAGGACAAGTAATTGGGATTACATCAAGTAAAATTGCAAGTAATGGTGGAACATCTGTAGA
AGGTCTTGGTTTTGCAATTCCTTCAAACGATGCACAAAATATCATTAAACAGCTTGAAAGTAATGGTAAAGTGACTCGTC
CAGCTCTTGGAATTCAAATGGTCAATCTGTCAAATGTTGGAGCTAGTGATCTTAGAAAACTTAACATTCCAAGTGGCCTC
ACTTCAGGTGTAGTTGTTCGATCTGTTCAAAACAATATGCCAGCAAATGGACATCTTCAAAAATACGATGTCATTACCAA
AGTTGACGATAAAGAGATTGCTTCATCAACAGACCTACAACACGCTCTTTACAATCATGCTATTGGAGATACTATCAAAG
TAACCTACTACCGTAATGGTAAGGAGGAAACAACCTCAATTAAACTAGATAAGAATTCTAGTGATTTAGAGTCTTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(294-389)

Trypsin-like peptidase domain (Trypsin_2)

(108-253)

Peptidase family M50 (Peptidase_M50)

(220-393)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A081R426

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

83.417

100

0.834
  htrA Streptococcus pneumoniae Rx1

82.663

100

0.827
  htrA Streptococcus pneumoniae D39

82.663

100

0.827
  htrA Streptococcus pneumoniae R6

82.663

100

0.827
  htrA Streptococcus pneumoniae TIGR4

82.663

100

0.827
  htrA Streptococcus gordonii str. Challis substr. CH1

67.164

100

0.678
  htrA Streptococcus mutans UA159

55.076

98.995

0.545