Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYA   Type   Machinery gene
Locus tag   P8191_RS06915 Genome accession   NZ_CP121250
Coordinates   1332234..1333172 (-) Length   312 a.a.
NCBI ID   WP_010921798.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain 1044     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1327234..1338172
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P8191_RS06875 (P8191_06875) - 1327249..1328445 (-) 1197 WP_010921803.1 acetate kinase -
  P8191_RS06880 (P8191_06880) comYH 1328504..1329457 (-) 954 WP_010921802.1 class I SAM-dependent methyltransferase Machinery gene
  P8191_RS06885 (P8191_06885) comGG 1329555..1329881 (-) 327 WP_010921801.1 competence type IV pilus minor pilin ComGG -
  P8191_RS06890 (P8191_06890) comYF 1329865..1330299 (-) 435 WP_010921800.1 competence type IV pilus minor pilin ComGF Machinery gene
  P8191_RS06895 (P8191_06895) comGE 1330292..1330576 (-) 285 WP_002987779.1 competence type IV pilus minor pilin ComGE -
  P8191_RS06900 (P8191_06900) comGD 1330533..1330961 (-) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD -
  P8191_RS06905 (P8191_06905) comYC 1330936..1331262 (-) 327 WP_002986552.1 competence type IV pilus major pilin ComGC Machinery gene
  P8191_RS06910 (P8191_06910) comYB 1331264..1332298 (-) 1035 WP_011054115.1 competence type IV pilus assembly protein ComGB Machinery gene
  P8191_RS06915 (P8191_06915) comYA 1332234..1333172 (-) 939 WP_010921798.1 competence type IV pilus ATPase ComGA Machinery gene
  P8191_RS06920 (P8191_06920) - 1333265..1333630 (-) 366 WP_002986560.1 DUF1033 family protein -
  P8191_RS06925 (P8191_06925) rpoC 1333782..1337423 (-) 3642 WP_010921797.1 DNA-directed RNA polymerase subunit beta' -

Sequence

Protein


Download         Length: 312 a.a.        Molecular weight: 35068.31 Da        Isoelectric Point: 8.5825

>NTDB_id=811349 P8191_RS06915 WP_010921798.1 1332234..1333172(-) (comYA) [Streptococcus pyogenes strain 1044]
MVQALAKAILAKAEQVHAQDIYILPRADQYDLFLRIGDERRLVDVYQSDRMAPLISHFKFVAGMIVGEKRRCQVGSCDYK
LSKDKQLSLRLSSVGDYRGQESLVIRLLHHQNKSVHYWFDGLTKVANQVGGRGLYLFAGPVGSGKTTLMYQLISNYHQEA
QVISIEDPVEIKNHQILQLQVNDDIGMTYDNLIKLSLRHRPDILVIGEIRDSQTARAVIRASLTGAMVFSTVHAKSISGV
YARLLELGVTKAELSNCLALIAYQRLLNGGALIDSTQNEFEYYSSSNWNQQIDQLLEAGHLNPKQAKLEKII

Nucleotide


Download         Length: 939 bp        

>NTDB_id=811349 P8191_RS06915 WP_010921798.1 1332234..1333172(-) (comYA) [Streptococcus pyogenes strain 1044]
ATGGTACAAGCATTAGCAAAAGCTATTCTAGCAAAAGCTGAACAGGTTCATGCACAAGATATTTATATTTTGCCAAGAGC
AGATCAATATGATCTTTTTTTACGAATAGGAGATGAAAGGAGATTAGTTGATGTTTATCAGAGCGATCGGATGGCTCCTC
TTATTAGTCACTTTAAATTCGTTGCAGGAATGATAGTTGGTGAAAAGAGACGTTGTCAGGTGGGTTCATGTGATTATAAG
CTTAGTAAAGATAAGCAGTTATCTTTGCGCTTATCTAGCGTGGGTGATTATCGCGGGCAAGAAAGCTTAGTGATTCGTCT
GCTTCATCATCAAAATAAAAGTGTACATTATTGGTTTGATGGATTGACAAAAGTAGCCAATCAGGTTGGCGGTAGAGGGT
TGTATTTATTTGCAGGACCAGTTGGGTCTGGGAAGACAACCTTGATGTACCAGCTGATTTCGAATTATCATCAAGAAGCA
CAGGTTATTAGTATAGAAGATCCTGTAGAAATTAAAAATCACCAAATTTTACAATTACAAGTGAATGATGATATTGGTAT
GACTTATGACAATTTGATCAAACTGTCTTTACGCCATCGACCAGATATTTTAGTTATTGGTGAGATTCGAGATAGTCAAA
CAGCAAGAGCCGTTATTAGGGCTAGTCTAACAGGTGCCATGGTTTTTTCAACGGTTCACGCTAAAAGTATCTCGGGTGTT
TATGCAAGATTGTTAGAACTTGGTGTAACGAAAGCAGAACTGTCTAATTGCTTAGCATTAATTGCTTACCAAAGGTTACT
TAATGGAGGAGCATTGATTGACTCTACTCAAAACGAATTTGAATATTATTCCTCATCGAACTGGAATCAACAAATTGATC
AGCTTCTTGAGGCAGGACATCTCAATCCCAAGCAAGCTAAGCTTGAAAAAATTATCTAG

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-267)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYA Streptococcus mutans UA140

61.736

99.679

0.615
  comYA Streptococcus mutans UA159

61.736

99.679

0.615
  comYA Streptococcus gordonii str. Challis substr. CH1

60.772

99.679

0.606
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

60.323

99.359

0.599
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

59.486

99.679

0.593
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

58.842

99.679

0.587
  comGA/cglA/cilD Streptococcus pneumoniae D39

58.842

99.679

0.587
  comGA/cglA/cilD Streptococcus pneumoniae R6

58.842

99.679

0.587
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

58.842

99.679

0.587
  comGA Lactococcus lactis subsp. cremoris KW2

50.482

99.679

0.503
  comGA Latilactobacillus sakei subsp. sakei 23K

39.655

92.949

0.369