Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   P1Y72_RS05360 Genome accession   NZ_CP119599
Coordinates   1124723..1125994 (+) Length   423 a.a.
NCBI ID   WP_010922754.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain 1133     
Function   require for competence (predicted from homology)   
Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1108029..1135714 1124723..1125994 within 0


Gene organization within MGE regions


Location: 1108029..1135714
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P1Y72_RS05240 (P1Y72_05240) - 1108029..1108412 (-) 384 WP_033887760.1 ArpU family phage packaging/lysis transcriptional regulator -
  P1Y72_RS05245 (P1Y72_05245) - 1108387..1108749 (-) 363 WP_002992136.1 DUF1492 domain-containing protein -
  P1Y72_RS05250 (P1Y72_05250) - 1109153..1109641 (-) 489 WP_136243670.1 hypothetical protein -
  P1Y72_RS05255 (P1Y72_05255) - 1109715..1110224 (-) 510 WP_002992482.1 hypothetical protein -
  P1Y72_RS05260 (P1Y72_05260) - 1110226..1110399 (-) 174 WP_014635784.1 hypothetical protein -
  P1Y72_RS05265 (P1Y72_05265) - 1110405..1110578 (-) 174 WP_000694577.1 hypothetical protein -
  P1Y72_RS05270 (P1Y72_05270) - 1110865..1112553 (-) 1689 WP_002992487.1 phage/plasmid primase, P4 family -
  P1Y72_RS05275 (P1Y72_05275) - 1112522..1113379 (-) 858 WP_136098354.1 primase alpha helix C-terminal domain-containing protein -
  P1Y72_RS05280 (P1Y72_05280) - 1113380..1113652 (-) 273 WP_001100459.1 hypothetical protein -
  P1Y72_RS05285 (P1Y72_05285) - 1113655..1113984 (-) 330 WP_003058810.1 hypothetical protein -
  P1Y72_RS05290 (P1Y72_05290) - 1113996..1114187 (-) 192 WP_010922764.1 hypothetical protein -
  P1Y72_RS05295 (P1Y72_05295) - 1114190..1114411 (-) 222 WP_010922763.1 hypothetical protein -
  P1Y72_RS05300 (P1Y72_05300) - 1114408..1114740 (-) 333 WP_002992497.1 hypothetical protein -
  P1Y72_RS05305 (P1Y72_05305) - 1114985..1115506 (-) 522 WP_002992498.1 Rha family transcriptional regulator -
  P1Y72_RS05310 (P1Y72_05310) - 1115789..1115911 (-) 123 WP_002992500.1 hypothetical protein -
  P1Y72_RS05315 (P1Y72_05315) - 1115924..1116331 (-) 408 WP_002992501.1 hypothetical protein -
  P1Y72_RS05320 (P1Y72_05320) - 1116394..1116552 (-) 159 Protein_1035 helix-turn-helix transcriptional regulator -
  P1Y72_RS05325 (P1Y72_05325) - 1116586..1116792 (-) 207 WP_002992503.1 helix-turn-helix transcriptional regulator -
  P1Y72_RS05330 (P1Y72_05330) - 1116946..1117713 (+) 768 WP_003058809.1 S24 family peptidase -
  P1Y72_RS05335 (P1Y72_05335) - 1119033..1120178 (+) 1146 WP_002992191.1 site-specific integrase -
  P1Y72_RS05340 (P1Y72_05340) mutL 1120273..1122255 (+) 1983 WP_159330786.1 DNA mismatch repair endonuclease MutL -
  P1Y72_RS05345 (P1Y72_05345) - 1122266..1123486 (+) 1221 WP_010922756.1 MFS transporter -
  P1Y72_RS05350 (P1Y72_05350) ruvA 1123488..1124084 (+) 597 WP_002992186.1 Holliday junction branch migration protein RuvA -
  P1Y72_RS05355 (P1Y72_05355) - 1124094..1124654 (+) 561 WP_010922755.1 DNA-3-methyladenine glycosylase I -
  P1Y72_RS05360 (P1Y72_05360) cinA 1124723..1125994 (+) 1272 WP_010922754.1 competence/damage-inducible protein A Machinery gene
  P1Y72_RS05365 (P1Y72_05365) recA 1126083..1127219 (+) 1137 WP_010922753.1 recombinase RecA Machinery gene
  P1Y72_RS05370 (P1Y72_05370) spx 1127510..1127908 (+) 399 WP_002982188.1 transcriptional regulator Spx -
  P1Y72_RS05375 (P1Y72_05375) - 1128021..1128290 (+) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  P1Y72_RS05380 (P1Y72_05380) ruvX 1128287..1128706 (+) 420 WP_010922752.1 Holliday junction resolvase RuvX -
  P1Y72_RS05385 (P1Y72_05385) - 1128718..1129023 (+) 306 WP_002982199.1 DUF1292 domain-containing protein -
  P1Y72_RS05390 (P1Y72_05390) - 1129436..1130995 (+) 1560 WP_136273970.1 DUF2079 domain-containing protein -
  P1Y72_RS05395 (P1Y72_05395) nrdD 1131092..1133290 (+) 2199 WP_002992831.1 anaerobic ribonucleoside-triphosphate reductase -
  P1Y72_RS05400 (P1Y72_05400) - 1133472..1133618 (+) 147 WP_002982210.1 hypothetical protein -
  P1Y72_RS05405 (P1Y72_05405) - 1133647..1134582 (+) 936 WP_010922750.1 Gfo/Idh/MocA family oxidoreductase -
  P1Y72_RS05410 (P1Y72_05410) - 1134591..1135100 (+) 510 WP_011018311.1 GNAT family N-acetyltransferase -
  P1Y72_RS05415 (P1Y72_05415) nrdG 1135100..1135714 (+) 615 WP_002982219.1 anaerobic ribonucleoside-triphosphate reductase activating protein -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45989.75 Da        Isoelectric Point: 4.9007

>NTDB_id=800056 P1Y72_RS05360 WP_010922754.1 1124723..1125994(+) (cinA) [Streptococcus pyogenes strain 1133]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSNLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=800056 P1Y72_RS05360 WP_010922754.1 1124723..1125994(+) (cinA) [Streptococcus pyogenes strain 1133]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTAACTTGGTAATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACGGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGTCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCTTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Competence-damaged protein (CinA)

(263-416)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.504

100

0.695
  cinA Streptococcus mitis SK321

70.024

98.582

0.69
  cinA Streptococcus mitis NCTC 12261

69.544

98.582

0.686
  cinA Streptococcus pneumoniae TIGR4

68.585

98.582

0.676
  cinA Streptococcus pneumoniae Rx1

68.585

98.582

0.676
  cinA Streptococcus pneumoniae R6

68.585

98.582

0.676
  cinA Streptococcus pneumoniae D39

68.345

98.582

0.674
  cinA Streptococcus suis isolate S10

53.365

98.345

0.525
  cinA Bacillus subtilis subsp. subtilis str. 168

46.411

98.818

0.459