Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   PY824_RS10990 Genome accession   NZ_CP119172
Coordinates   2112722..2113981 (-) Length   419 a.a.
NCBI ID   WP_039671315.1    Uniprot ID   A0A081JEP9
Organism   Streptococcus macedonicus strain SGM CIP105683     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 2107722..2118981
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PY824_RS10960 (PY824_10960) - 2108151..2109407 (+) 1257 WP_115265893.1 ISL3 family transposase -
  PY824_RS10965 (PY824_10965) - 2109494..2109811 (-) 318 WP_006531413.1 DUF1292 domain-containing protein -
  PY824_RS10970 (PY824_10970) ruvX 2109844..2110263 (-) 420 WP_006531414.1 Holliday junction resolvase RuvX -
  PY824_RS10975 (PY824_10975) - 2110260..2110529 (-) 270 WP_003066890.1 IreB family regulatory phosphoprotein -
  PY824_RS10980 (PY824_10980) spx 2110851..2111249 (-) 399 WP_009855164.1 transcriptional regulator Spx -
  PY824_RS10985 (PY824_10985) recA 2111518..2112672 (-) 1155 WP_039671314.1 recombinase RecA Machinery gene
  PY824_RS10990 (PY824_10990) cinA 2112722..2113981 (-) 1260 WP_039671315.1 competence/damage-inducible protein A Machinery gene
  PY824_RS10995 (PY824_10995) - 2114139..2114576 (-) 438 WP_014295451.1 hypothetical protein -
  PY824_RS11000 (PY824_11000) - 2114814..2115077 (-) 264 WP_223246337.1 hypothetical protein -
  PY824_RS11005 (PY824_11005) - 2115237..2115410 (-) 174 WP_039671316.1 hypothetical protein -
  PY824_RS11010 (PY824_11010) - 2115460..2115762 (-) 303 WP_014295454.1 hypothetical protein -
  PY824_RS11015 (PY824_11015) - 2115781..2115924 (-) 144 WP_014295455.1 hypothetical protein -
  PY824_RS11020 (PY824_11020) - 2116017..2116872 (+) 856 Protein_2113 helix-turn-helix transcriptional regulator -
  PY824_RS11025 (PY824_11025) ruvA 2116946..2117539 (-) 594 WP_014295457.1 Holliday junction branch migration protein RuvA -

Sequence

Protein


Download         Length: 419 a.a.        Molecular weight: 45500.91 Da        Isoelectric Point: 5.1773

>NTDB_id=798074 PY824_RS10990 WP_039671315.1 2112722..2113981(-) (cinA) [Streptococcus macedonicus strain SGM CIP105683]
MKAEIIAVGTEILTGQITNTNAQFLSEEFAKLGIDVFFQTAVGDNEERLLSVINLASKRSELVVLCGGLGPTEDDLTKQT
LAKYLGRDLFFDEQANKRLDEFFATRPQFARTANNERQAQLIEGSIPLPNSTGLAVGGVLEVNGVTYVVLPGPPSELKPM
VLDSLVPLLSGDHRQLYSRVLRFFGIGESQLVTVLTDLIDNQTDPTIAPYAKTGEVTLRLSTKANDVTSAKAKLDALEHK
ILAKKTLNSILLEQLLYGYGDDNSMARVVFELLKEKHKTITAAESLTAGLFQSSIADFSGSSAVFNGGFVTYSIEEKSKM
LHIPLEDLQEHGVVSHFTAEKMAEQSRLLTDADFGIGLTGVAGPDSLEGHPAGTVFIGIATREKVHSIRVVIGGRSRSDV
RYIATLYAFNLVRQALLQG

Nucleotide


Download         Length: 1260 bp        

>NTDB_id=798074 PY824_RS10990 WP_039671315.1 2112722..2113981(-) (cinA) [Streptococcus macedonicus strain SGM CIP105683]
ATGAAAGCTGAAATCATTGCTGTGGGAACAGAAATTCTAACAGGACAAATCACAAATACAAATGCTCAATTTTTATCGGA
AGAATTTGCCAAGTTAGGAATTGATGTGTTCTTTCAAACAGCTGTTGGTGATAATGAAGAACGTCTTTTATCAGTTATTA
ATTTAGCAAGCAAGCGAAGTGAATTAGTTGTCTTATGTGGAGGGCTTGGTCCGACAGAAGACGATTTAACAAAACAAACG
TTAGCAAAATATTTGGGACGCGATTTATTCTTTGATGAACAAGCCAACAAGCGTTTGGACGAATTTTTTGCGACACGTCC
GCAGTTTGCTAGAACGGCTAATAACGAACGTCAAGCACAGCTGATTGAAGGGTCAATACCGTTGCCAAATAGCACTGGTT
TGGCTGTTGGTGGCGTGCTAGAAGTAAATGGCGTGACCTACGTTGTTCTCCCTGGACCGCCGAGTGAATTAAAACCAATG
GTATTGGATTCTCTAGTACCTTTATTGTCTGGAGACCATAGGCAGCTTTATTCACGTGTGTTGCGTTTCTTTGGTATTGG
TGAAAGCCAGTTAGTGACCGTTTTGACAGATTTGATTGATAATCAAACAGACCCAACGATTGCTCCGTATGCGAAAACAG
GTGAGGTGACCCTTCGTTTATCAACCAAGGCAAATGATGTGACGTCAGCAAAAGCGAAATTGGATGCTCTAGAGCATAAA
ATTCTAGCTAAAAAAACATTAAATAGTATTCTTCTTGAACAGTTACTTTATGGCTATGGTGATGATAACAGTATGGCGCG
TGTTGTTTTTGAGTTGTTGAAAGAAAAGCACAAAACCATTACAGCGGCAGAAAGTTTGACTGCAGGGCTATTCCAATCTA
GTATCGCTGATTTTTCAGGGTCATCTGCAGTATTTAATGGCGGATTTGTGACGTATAGTATAGAAGAAAAATCAAAAATG
CTTCACATTCCTCTTGAAGATTTGCAAGAACATGGTGTAGTAAGTCACTTTACAGCTGAAAAAATGGCAGAGCAATCACG
TTTATTGACAGATGCTGATTTTGGTATCGGTTTGACAGGTGTTGCAGGACCAGATAGCTTAGAAGGACATCCAGCAGGAA
CAGTTTTCATTGGTATTGCTACTAGAGAAAAAGTTCATTCTATTCGTGTTGTTATAGGTGGACGAAGCCGTTCAGACGTC
CGTTATATTGCTACTTTATATGCTTTCAACTTAGTACGTCAAGCTTTATTACAAGGATAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(263-415)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-241)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A081JEP9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

72.182

99.523

0.718
  cinA Streptococcus mitis SK321

71.531

99.761

0.714
  cinA Streptococcus mitis NCTC 12261

71.292

99.761

0.711
  cinA Streptococcus pneumoniae Rx1

70.335

99.761

0.702
  cinA Streptococcus pneumoniae TIGR4

70.335

99.761

0.702
  cinA Streptococcus pneumoniae R6

70.335

99.761

0.702
  cinA Streptococcus pneumoniae D39

70.096

99.761

0.699
  cinA Streptococcus suis isolate S10

53.365

99.284

0.53
  cinA Bacillus subtilis subsp. subtilis str. 168

45.735

100

0.461