Detailed information NTG0789500

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: PUW62_RS10600
• Genome accession: NZ_CP118046
• Coordinates: 2076211..2076960 (-)
• Length: 249 a.a.
• NCBI ID: WP_024052478.1
• Uniprot ID: A0A412PLH3
• Organism: Streptococcus anginosus strain VSI52
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2071211..2081960

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PUW62_RS10580 (PUW62_10580)	-	2071598..2073220 (+)	1623	WP_274997111.1	ATP-binding cassette domain-containing protein	-
PUW62_RS10585 (PUW62_10585)	-	2073287..2075863 (+)	2577	WP_024052479.1	YfhO family protein	-
PUW62_RS10600 (PUW62_10600)	comE	2076211..2076960 (-)	750	WP_024052478.1	competence system response regulator transcription factor ComE	Regulator
PUW62_RS10605 (PUW62_10605)	comD/comD2	2076960..2078285 (-)	1326	WP_207047776.1	GHKL domain-containing protein	Regulator
PUW62_RS10610 (PUW62_10610)	-	2078303..2078449 (-)	147	WP_003029519.1	bacteriocin	-
PUW62_RS10620 (PUW62_10620)	rlmH	2078731..2079210 (-)	480	WP_024052476.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
PUW62_RS10625 (PUW62_10625)	htrA	2079404..2080594 (+)	1191	WP_024052475.1	trypsin-like peptidase domain-containing protein	Regulator
PUW62_RS10630 (PUW62_10630)	spo0J	2080649..2081416 (+)	768	WP_070672281.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29243.90 Da
• Isoelectric Point: 8.6042

>NTDB_id=789500 PUW62_RS10600 WP_024052478.1 2076211..2076960(-) (comE) [Streptococcus anginosus strain VSI52]
MKVLVLEDEITHQVRMETTLAEIAKEMGITIKVKVTGKVREFKEYIENDEVNQLYFLDIDIKGEETKGLEIAKFIRHHNP
YAIIVFVTTKSEFATMTFKYKVSALDFVDKNLSDVAFKKHIKDSIEYTKATLIENKDMVDYFEYNFRGGEVRMPFNDILY
IETTGSSHKLRIVGKNFFKEFYGTIADIQEKDKETRRFFSPHKSYLVNIGNIKGYDKKMREIIFYEDHRCPITRMKIGKL
KAILEELKG

Nucleotide

• Length: 750 bp

>NTDB_id=789500 PUW62_RS10600 WP_024052478.1 2076211..2076960(-) (comE) [Streptococcus anginosus strain VSI52]
ATGAAAGTATTAGTATTAGAAGATGAAATTACACATCAAGTAAGAATGGAAACAACTTTGGCAGAGATTGCAAAAGAAAT
GGGAATTACGATAAAAGTTAAAGTAACTGGAAAAGTAAGGGAATTTAAAGAATATATTGAAAACGATGAAGTAAATCAAT
TATATTTTTTAGATATTGATATCAAAGGAGAGGAAACAAAAGGTTTAGAAATAGCAAAATTTATACGTCATCACAATCCG
TATGCCATTATTGTTTTTGTTACAACGAAATCAGAATTTGCCACTATGACCTTCAAATATAAGGTATCTGCACTGGATTT
TGTTGACAAAAATTTGAGTGATGTTGCTTTTAAAAAACATATAAAAGACAGCATTGAGTATACAAAAGCGACATTGATTG
AAAATAAAGATATGGTGGATTATTTTGAATATAACTTTCGTGGCGGAGAGGTTAGAATGCCTTTTAATGACATTTTATAT
ATTGAAACGACAGGCTCTTCTCATAAATTAAGAATTGTCGGTAAAAACTTTTTTAAAGAATTCTATGGCACTATTGCAGA
TATTCAAGAAAAAGATAAAGAAACAAGACGTTTCTTTTCACCTCATAAATCCTACCTAGTCAATATTGGAAACATCAAAG
GTTATGACAAAAAAATGCGAGAAATAATTTTTTATGAAGATCATCGTTGTCCGATTACTCGAATGAAAATTGGAAAATTA
AAAGCTATTTTAGAGGAATTAAAAGGATAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (152-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: A0A412PLH3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	71.02	98.394	0.699
comE	Streptococcus mitis SK321	70.204	98.394	0.691
comE	Streptococcus infantis strain Atu-4	70.204	98.394	0.691
comE	Streptococcus pneumoniae Rx1	69.796	98.394	0.687
comE	Streptococcus pneumoniae D39	69.796	98.394	0.687
comE	Streptococcus pneumoniae R6	69.796	98.394	0.687
comE	Streptococcus pneumoniae TIGR4	69.796	98.394	0.687
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	70.082	97.992	0.687
comE/comE2	Streptococcus gordonii strain NCTC7865	70.082	97.992	0.687
comE/blpR	Streptococcus mutans UA159	40.486	99.197	0.402
comE/comE2	Streptococcus equinus JB1	34.749	100	0.361