Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/celA/cilE   Type   Machinery gene
Locus tag   UKS_RS04370 Genome accession   NZ_AP021887
Coordinates   846942..847592 (+) Length   216 a.a.
NCBI ID   WP_156011948.1    Uniprot ID   A0A6H3SKI3
Organism   Streptococcus sp. 116-D4     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 841942..852592
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  UKS_RS04340 (UKS_08100) cvfB 842213..843067 (+) 855 WP_156011944.1 RNA-binding virulence regulatory protein CvfB -
  UKS_RS04345 (UKS_08110) - 843079..843636 (+) 558 WP_049495610.1 GrpB family protein -
  UKS_RS04350 (UKS_08120) - 843682..843897 (+) 216 WP_001232084.1 YozE family protein -
  UKS_RS04355 (UKS_08130) - 843982..844956 (+) 975 WP_156011945.1 PhoH family protein -
  UKS_RS04360 (UKS_08140) ald 845020..846132 (-) 1113 WP_156011946.1 alanine dehydrogenase -
  UKS_RS04365 (UKS_08150) - 846306..846875 (+) 570 WP_156011947.1 GNAT family N-acetyltransferase -
  UKS_RS04370 (UKS_08160) comEA/celA/cilE 846942..847592 (+) 651 WP_156011948.1 helix-hairpin-helix domain-containing protein Machinery gene
  UKS_RS04375 (UKS_08170) comEC/celB 847576..849816 (+) 2241 WP_156011949.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  UKS_RS04380 (UKS_08180) - 849947..850195 (+) 249 WP_332066893.1 hypothetical protein -
  UKS_RS04385 (UKS_08190) - 850228..850815 (+) 588 WP_156011951.1 ABC transporter ATP-binding protein -
  UKS_RS04390 (UKS_08200) - 850819..852003 (+) 1185 WP_156011952.1 hypothetical protein -

Sequence

Protein


Download         Length: 216 a.a.        Molecular weight: 23158.51 Da        Isoelectric Point: 6.9974

>NTDB_id=75353 UKS_RS04370 WP_156011948.1 846942..847592(+) (comEA/celA/cilE) [Streptococcus sp. 116-D4]
MEAIIEKIKEYKIIVICTSLGLLVSGFFLLKPAPPTPVKERNLQAEVAAVSKDSVSEKEMKKEEKEEPIEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKGLNLAQKVSDEALVYVPSKGEAAASQQAGSGAPSSTSKDKKVNLNKA
NLEELKQVKGLGGKRAQDIIDHRETNGQFKSVDELKKVSGIGAKTIEKLKDYVAVD

Nucleotide


Download         Length: 651 bp        

>NTDB_id=75353 UKS_RS04370 WP_156011948.1 846942..847592(+) (comEA/celA/cilE) [Streptococcus sp. 116-D4]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATTTGTACTAGTCTGGGCTTGCTTGTAAGCGGATT
TTTCCTGCTAAAGCCAGCTCCACCAACACCTGTTAAGGAAAGGAATCTACAAGCAGAAGTCGCAGCTGTTTCCAAGGATT
CAGTGTCCGAAAAGGAAATGAAGAAGGAAGAAAAGGAAGAACCTATTGAACAAGATCTAATCACAGTAGATGTGAAAGGT
GCTGTCAAATCACCAGGAATTTATGATTTGCCAGTCGGTAGTCGGGTCAATGACGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGGGGCTCAATCTAGCTCAGAAAGTTAGTGACGAGGCTCTGGTTTACGTTCCATCTAAGGGAG
AAGCAGCAGCTAGTCAACAGGCAGGTTCTGGAGCGCCTTCTTCAACAAGCAAGGACAAGAAGGTCAATCTCAACAAGGCC
AATCTGGAAGAACTCAAGCAGGTCAAGGGGCTGGGAGGAAAACGAGCCCAGGATATTATCGACCATCGTGAAACAAATGG
GCAATTCAAGTCGGTTGATGAACTCAAGAAGGTATCCGGCATTGGAGCCAAGACCATAGAAAAGTTAAAAGATTATGTTG
CAGTGGATTAA

Domains

Predicted by InterproScan.

Helix-hairpin-helix motif (HHH_3)

(152-213)

SLBB domain (SLBB)

(76-126)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6H3SKI3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/celA/cilE Streptococcus mitis NCTC 12261

91.667

100

0.917
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

90.278

100

0.903
  comEA/celA/cilE Streptococcus pneumoniae D39

89.352

100

0.894
  comEA/celA/cilE Streptococcus pneumoniae R6

89.352

100

0.894
  comEA/celA/cilE Streptococcus pneumoniae Rx1

89.352

100

0.894
  comEA/celA/cilE Streptococcus mitis SK321

88.889

100

0.889
  comEA Lactococcus lactis subsp. cremoris KW2

40

100

0.417
  comEA Streptococcus thermophilus LMD-9

39.13

100

0.417
  comEA Bacillus subtilis subsp. subtilis str. 168

38.835

95.37

0.37

Multiple sequence alignment