Detailed information NTG0721610

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: PVK49_RS01200
• Genome accession: NZ_CP118306
• Coordinates: 219010..219750 (+)
• Length: 246 a.a.
• NCBI ID: WP_002986100.1
• Uniprot ID: A0A0H2UT50
• Organism: Streptococcus pyogenes strain 20154608
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 214010..224750

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PVK49_RS01185 (PVK49_01185)	gltX	214541..215986 (+)	1446	WP_047235640.1	glutamate--tRNA ligase	-
PVK49_RS01190 (PVK49_01190)	-	216380..217726 (+)	1347	WP_047235641.1	sensor histidine kinase	-
PVK49_RS01195 (PVK49_01195)	-	217723..219006 (+)	1284	WP_047235642.1	sensor histidine kinase	-
PVK49_RS01200 (PVK49_01200)	comE/blpR	219010..219750 (+)	741	WP_002986100.1	LytTR family DNA-binding domain-containing protein	Regulator
PVK49_RS01205 (PVK49_01205)	rnpA	220290..220649 (+)	360	WP_002992035.1	ribonuclease P protein component	-
PVK49_RS01210 (PVK49_01210)	-	220615..221442 (+)	828	WP_080343536.1	YidC/Oxa1 family membrane protein insertase	-
PVK49_RS01215 (PVK49_01215)	jag	221454..222368 (+)	915	WP_047235644.1	RNA-binding cell elongation regulator Jag/EloR	-
PVK49_RS01220 (PVK49_01220)	rpmH	222683..222817 (+)	135	WP_002885866.1	50S ribosomal protein L34	-
PVK49_RS01225 (PVK49_01225)	-	223091..223795 (+)	705	WP_047235645.1	N-acetylmannosamine-6-phosphate 2-epimerase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28881.47 Da
• Isoelectric Point: 6.4841

>NTDB_id=721610 PVK49_RS01200 WP_002986100.1 219010..219750(+) (comE/blpR) [Streptococcus pyogenes strain 20154608]
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQERGDHQLYFLDIEIGEYTRCGLELAAAIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFE
RWEALR

Nucleotide

• Length: 741 bp

>NTDB_id=721610 PVK49_RS01200 WP_002986100.1 219010..219750(+) (comE/blpR) [Streptococcus pyogenes strain 20154608]
ATGATGAACATTTTTATTCTTGAGGATGATTTTATCCAGCAGACACGCATAGAATCTATCGTAGTAGGCATCTTAAAAGA
GACTAGAATACCATGTAATCAGCTTGAAGTGTTCTCGACTCCTCAAAAATTATTTGAGAGTATCCAAGAAAGAGGAGACC
ATCAGCTGTATTTTTTAGATATTGAAATTGGTGAATATACTCGTTGTGGGCTTGAATTAGCTGCAGCTATTCGACAAAAA
GATCCTAATGCCGTTATTGTGTTTGTCACCACTCATTCAGAATTTGCTCCTATTTCTTTTAAATATAAGGTATCTGCTCT
AGATTTTATTGATAAAGCAGGTGGTCAAAAACAGTTTAAAGAACAAATCGAAGAATGTATCCGATATACTTACGATATGA
TGTCTAGTCGTGAGTCAAAGGACATGTTTTTATTTGAGACTCCACAGACAAGATTAAAATTGCCTTATAAGGATATTTTA
TACTTTGCTACAGCCACAACTCCTCACAAAGTTTGTTTATGGACTCAGACAGAAAGATTAGAGTTTTATGGTAATCTATC
TGAGATTCAAGCAGTAGCACCGAAACTTTTTTTGTGCCATAGATCCTACCTTGTGAATCTAGATAAGGTTGTTCGAATTG
ATAAGAGTAAGCAGCTCCTTTATTTCGAAAATGGTGATTCTTGTATGGTATCACGGTTAAAAATGAAATGTCTGTTTGAA
CGGTGGGAGGCCCTTCGCTAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-123)

3D structure

• AlphaFold DB: A0A0H2UT50

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	46.862	97.154	0.455
comE/comE1	Streptococcus equinus JB1	41.597	96.748	0.402
comE/comE2	Streptococcus equinus JB1	39.431	100	0.394
comE	Streptococcus pneumoniae Rx1	38.525	99.187	0.382
comE	Streptococcus pneumoniae D39	38.525	99.187	0.382
comE	Streptococcus pneumoniae R6	38.525	99.187	0.382
comE	Streptococcus pneumoniae TIGR4	38.525	99.187	0.382
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.903	100	0.382
comE/comE2	Streptococcus gordonii strain NCTC7865	37.903	100	0.382
comE	Streptococcus mitis NCTC 12261	37.759	97.967	0.37
comE	Streptococcus mitis SK321	37.759	97.967	0.37