Detailed information NTG0717862

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: MGCS35823_RS09865
• Genome accession: NZ_CP117289
• Coordinates: 1974493..1975233 (-)
• Length: 246 a.a.
• NCBI ID: WP_003061418.1
• Uniprot ID: Q8KQN2
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain MGCS35823
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1969493..1980233

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGCS35823_RS09840 (MGCS35823_04006)	-	1970392..1971096 (-)	705	WP_003056091.1	N-acetylmannosamine-6-phosphate 2-epimerase	-
MGCS35823_RS09845 (MGCS35823_04008)	rpmH	1971426..1971560 (-)	135	WP_002885866.1	50S ribosomal protein L34	-
MGCS35823_RS09850 (MGCS35823_04010)	jag	1971873..1972787 (-)	915	WP_003056081.1	RNA-binding cell elongation regulator Jag/EloR	-
MGCS35823_RS09855 (MGCS35823_04012)	-	1972799..1973626 (-)	828	WP_100249539.1	YidC/Oxa1 family membrane protein insertase	-
MGCS35823_RS09860 (MGCS35823_04014)	rnpA	1973592..1973951 (-)	360	WP_003056083.1	ribonuclease P protein component	-
MGCS35823_RS09865 (MGCS35823_04018)	comE/blpR	1974493..1975233 (-)	741	WP_003061418.1	LytTR family DNA-binding domain-containing protein	Regulator
MGCS35823_RS09870 (MGCS35823_04020)	-	1975237..1976520 (-)	1284	WP_084916681.1	sensor histidine kinase	-
MGCS35823_RS09875 (MGCS35823_04022)	-	1976521..1977864 (-)	1344	WP_015058070.1	GHKL domain-containing protein	-
MGCS35823_RS09880 (MGCS35823_04024)	gltX	1978479..1979927 (-)	1449	WP_014612594.1	glutamate--tRNA ligase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28977.28 Da
• Isoelectric Point: 4.8645

>NTDB_id=717862 MGCS35823_RS09865 WP_003061418.1 1974493..1975233(-) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain MGCS35823]
MMNIFILEDDFIQQTRIESVVADILEEAKIPCNQLEVFANPHKLFESIQERGDHQLYFLDIEIGDEDRRGLELAADIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAVDKQQFRDQIEECIRYTYEMMSSRESEDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFDNGDSCMVSRLKMKCLFE
KWEALH

Nucleotide

• Length: 741 bp

>NTDB_id=717862 MGCS35823_RS09865 WP_003061418.1 1974493..1975233(-) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain MGCS35823]
ATGATGAATATTTTTATTCTTGAAGATGATTTTATCCAACAGACACGTATTGAATCTGTAGTGGCAGACATCTTGGAAGA
AGCTAAAATCCCTTGTAATCAGCTAGAAGTGTTTGCCAATCCTCATAAATTATTTGAAAGCATTCAAGAAAGAGGCGATC
ACCAGCTATATTTTTTAGACATTGAGATTGGTGATGAGGATCGCCGAGGGCTTGAATTGGCAGCAGATATTCGACAAAAA
GACCCCAATGCGGTCATTGTGTTTGTTACCACACATTCTGAATTTGCTCCTATTTCTTTTAAATACAAAGTGTCTGCCTT
AGATTTTATTGACAAAGCAGTTGATAAACAACAATTTAGGGATCAGATTGAAGAATGTATCCGCTATACCTATGAGATGA
TGTCTAGCCGAGAATCAGAAGACATGTTTTTATTTGAGACCCCTCAGACAAGGTTAAAATTACCTTACAAAGATATCCTT
TATTTTGCTACTGCTACGACACCCCACAAGGTGTGTTTGTGGACTCAGACGGAGAGACTGGAGTTTTATGGTAATTTATC
TGAGATACAAGCTGTGGCTCCAAAGCTTTTCTTATGCCATAGATCTTACTTGGTTAATCTAGATAAGGTTGTGCGTATTG
ATAAATCCAAACAGCTCCTCTATTTCGATAATGGGGATTCCTGTATGGTCTCACGCTTAAAAATGAAATGCCTTTTTGAA
AAATGGGAAGCCTTACATTAA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (152-242)

3D structure

• AlphaFold DB: Q8KQN2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	47.699	97.154	0.463
comE/comE1	Streptococcus equinus JB1	42.437	96.748	0.411
comE/comE2	Streptococcus equinus JB1	40.408	99.593	0.402
comE/comE2	Streptococcus gordonii strain NCTC7865	39.113	100	0.394
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	39.113	100	0.394