Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   MOP79_RS06040 Genome accession   NZ_CP102583
Coordinates   1180142..1181323 (+) Length   393 a.a.
NCBI ID   WP_000681597.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain D39Mega17545     
Function   degrading CSP; selective degradation of ComEA and ComEC (predicted from homology)   
Competence regulation

Genomic Context

Location: 1175142..1186323
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MOP79_RS06000 - 1176193..1176735 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  MOP79_RS06015 comE 1176978..1177730 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  MOP79_RS06020 comD/comD1 1177727..1179052 (-) 1326 WP_000362880.1 competence system sensor histidine kinase ComD Regulator
  MOP79_RS06025 comC/comC1 1179073..1179198 (-) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  MOP79_RS06035 rlmH 1179480..1179959 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  MOP79_RS06040 htrA 1180142..1181323 (+) 1182 WP_000681597.1 S1C family serine protease Regulator
  MOP79_RS06045 spo0J 1181381..1182139 (+) 759 WP_000410378.1 ParB/RepB/Spo0J family partition protein Regulator
  MOP79_RS06050 dnaA 1182352..1183713 (+) 1362 WP_000660615.1 chromosomal replication initiator protein DnaA -
  MOP79_RS06055 dnaN 1183872..1185008 (+) 1137 WP_000581138.1 DNA polymerase III subunit beta -
  MOP79_RS06060 - 1185073..1185267 (+) 195 WP_000285191.1 DUF951 domain-containing protein -

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41841.72 Da        Isoelectric Point: 6.8902

>NTDB_id=717865 MOP79_RS06040 WP_000681597.1 1180142..1181323(+) (htrA) [Streptococcus pneumoniae strain D39Mega17545]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVI
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=717865 MOP79_RS06040 WP_000681597.1 1180142..1181323(+) (htrA) [Streptococcus pneumoniae strain D39Mega17545]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAAATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAATT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(103-248)

PDZ domain (PDZ_2)

(289-384)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus pneumoniae Rx1

100

100

1
  htrA Streptococcus pneumoniae D39

100

100

1
  htrA Streptococcus pneumoniae R6

100

100

1
  htrA Streptococcus pneumoniae TIGR4

100

100

1
  htrA Streptococcus mitis NCTC 12261

97.201

100

0.972
  htrA Streptococcus gordonii str. Challis substr. CH1

66.414

100

0.669
  htrA Streptococcus mutans UA159

54.569

100

0.547