NTDB

Overview

Name	comEA/celA/cilE	Type	Machinery gene
Locus tag	NLY76_RS06040	Genome accession	NZ_CP100430
Coordinates	1257718..1258380 (-)	Length	220 a.a.
NCBI ID	WP_014638159.1	Uniprot ID	G7SI21
Organism	Streptococcus suis strain LSS42
Function	dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1252718..1263380

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NLY76_RS06020 (NLY76_06020)	-	1253595..1254422 (-)	828	WP_044770262.1	hypothetical protein	-
NLY76_RS06025 (NLY76_06025)	-	1254516..1255172 (-)	657	WP_024396040.1	CBS domain-containing protein	-
NLY76_RS06030 (NLY76_06030)	-	1255355..1255480 (-)	126	Protein_1143	IS982 family transposase	-
NLY76_RS06035 (NLY76_06035)	comEC/celB	1255497..1257734 (-)	2238	WP_024389357.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
NLY76_RS06040 (NLY76_06040)	comEA/celA/cilE	1257718..1258380 (-)	663	WP_014638159.1	helix-hairpin-helix domain-containing protein	Machinery gene
NLY76_RS06045 (NLY76_06045)	-	1258447..1259193 (-)	747	WP_014638160.1	1-acyl-sn-glycerol-3-phosphate acyltransferase	-
NLY76_RS06050 (NLY76_06050)	-	1259340..1260785 (+)	1446	WP_044686700.1	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	-
NLY76_RS06055 (NLY76_06055)	-	1261200..1261985 (+)	786	WP_044770261.1	ABC transporter ATP-binding protein	-
NLY76_RS06060 (NLY76_06060)	-	1261998..1262927 (+)	930	WP_015646964.1	ABC transporter substrate-binding protein	-

Sequence

Protein

Download Length: 220 a.a. Molecular weight: 23437.21 Da Isoelectric Point: 4.1234

                                >NTDB_id=705218 NLY76_RS06040 WP_014638159.1 1257718..1258380(-) (comEA/celA/cilE) [Streptococcus suis strain LSS42]

MDTIKTYIEMLKEYKWQIALPAVAGLLMATFLIFSQPAKSDQTGLTDFPQTEQTSSSSDLVEETSTEVSKEPSLLVVDVK

GAVVKPGLYTLEADARVNDAVEAAGGLTSQADPKSINLAQKLSDEAVVYVASKDENISVVASTTTSSAMSQEEKNTSLVN

LNTATEADLQTISGIGAKRATDIIAYREANGGFKSVDDLNNVSGIGDKTMESIRPYVTVD

Nucleotide

Download Length: 663 bp

                                >NTDB_id=705218 NLY76_RS06040 WP_014638159.1 1257718..1258380(-) (comEA/celA/cilE) [Streptococcus suis strain LSS42]

ATGGATACGATTAAAACTTATATAGAAATGCTTAAAGAATACAAGTGGCAAATTGCTCTGCCCGCAGTGGCTGGCTTGCT

AATGGCGACGTTTTTAATCTTCAGTCAACCAGCCAAGTCTGACCAGACAGGACTGACAGACTTTCCACAGACCGAACAAA

CTTCTAGCAGCTCTGACTTGGTCGAGGAAACCAGTACAGAAGTAAGTAAGGAGCCCAGCCTGCTGGTCGTTGATGTCAAA

GGAGCGGTAGTAAAACCAGGACTCTACACTTTAGAAGCTGATGCGCGTGTTAATGATGCAGTTGAAGCAGCTGGTGGCTT

GACCAGTCAGGCAGATCCCAAATCTATCAATCTGGCTCAGAAGCTCAGCGACGAGGCGGTGGTCTATGTGGCCAGCAAGG

ATGAAAATATCTCGGTGGTGGCCAGCACGACTACCAGCTCTGCTATGTCCCAAGAAGAAAAAAACACCAGTCTAGTCAAT

CTGAATACGGCGACTGAGGCGGACTTGCAGACCATTTCTGGTATTGGTGCCAAGCGAGCGACGGACATTATCGCCTATCG

TGAGGCCAACGGCGGCTTCAAGTCAGTGGACGACCTCAACAATGTTTCGGGCATTGGCGACAAGACCATGGAAAGCATTC

GACCTTATGTCACGGTCGATTAA

Domains

Predicted by InterproScan.

SLBB domain (SLBB)

(76-130)

Helix-hairpin-helix motif (HHH_3)

(155-218)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	G7SI21

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comEA/celA/cilE	Streptococcus pneumoniae Rx1	49.315	99.545	0.491
comEA/celA/cilE	Streptococcus pneumoniae D39	49.315	99.545	0.491
comEA/celA/cilE	Streptococcus pneumoniae R6	49.315	99.545	0.491
comEA/celA/cilE	Streptococcus mitis NCTC 12261	49.315	99.545	0.491
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	48.858	99.545	0.486
comEA/celA/cilE	Streptococcus mitis SK321	46.847	100	0.473
comEA	Streptococcus thermophilus LMD-9	60.784	69.545	0.423
comEA	Lactococcus lactis subsp. cremoris KW2	41.014	98.636	0.405
comEA	Bacillus subtilis subsp. subtilis str. 168	38.095	95.455	0.364

Detailed information NTG0705218