Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   MDRSPN_RS08995 Genome accession   NZ_AP018391
Coordinates   1707292..1708548 (-) Length   418 a.a.
NCBI ID   WP_061588623.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain MDRSPN001     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1699159..1739809 1707292..1708548 within 0


Gene organization within MGE regions


Location: 1699159..1739809
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MDRSPN_RS08940 (MDRSPN_01706) - 1699456..1700007 (-) 552 WP_001111247.1 hypothetical protein -
  MDRSPN_RS08945 (MDRSPN_01707) - 1699997..1700194 (-) 198 WP_000890144.1 hypothetical protein -
  MDRSPN_RS08950 (MDRSPN_01708) - 1700198..1700992 (-) 795 WP_120164272.1 hypothetical protein -
  MDRSPN_RS08955 (MDRSPN_01709) - 1701390..1701815 (-) 426 WP_000204070.1 hypothetical protein -
  MDRSPN_RS08960 (MDRSPN_01710) - 1701944..1702303 (-) 360 WP_000749821.1 ImmA/IrrE family metallo-endopeptidase -
  MDRSPN_RS08965 (MDRSPN_01711) - 1702349..1702555 (-) 207 WP_000366087.1 hypothetical protein -
  MDRSPN_RS08970 - 1702542..1702703 (-) 162 WP_000289348.1 helix-turn-helix domain-containing protein -
  MDRSPN_RS08975 (MDRSPN_01712) lytA 1703062..1704018 (-) 957 WP_120164273.1 N-acetylmuramoyl-L-alanine amidase LytA -
  MDRSPN_RS08980 (MDRSPN_01713) - 1704394..1705764 (-) 1371 WP_001036271.1 MATE family efflux transporter -
  MDRSPN_RS08990 (MDRSPN_01714) recA 1706071..1707237 (-) 1167 WP_120164274.1 recombinase RecA Machinery gene
  MDRSPN_RS08995 (MDRSPN_01715) cinA 1707292..1708548 (-) 1257 WP_061588623.1 competence/damage-inducible protein A Machinery gene
  MDRSPN_RS09000 (MDRSPN_01716) brpA 1708622..1709659 (-) 1038 WP_120164275.1 biofilm formation/cell division transcriptional regulator BrpA -
  MDRSPN_RS09005 (MDRSPN_01717) - 1709667..1710185 (-) 519 WP_000455536.1 GNAT family N-acetyltransferase -
  MDRSPN_RS09010 (MDRSPN_01718) tsaE 1710175..1710618 (-) 444 WP_000288230.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  MDRSPN_RS09015 (MDRSPN_01719) comM 1710704..1711324 (-) 621 WP_000839909.1 hypothetical protein Regulator
  MDRSPN_RS09025 (MDRSPN_01720) - 1711630..1712493 (-) 864 WP_001093609.1 helix-turn-helix domain-containing protein -
  MDRSPN_RS11535 (MDRSPN_01721) - 1712684..1712854 (+) 171 WP_001227863.1 PhrA family quorum-sensing system peptide -
  MDRSPN_RS09040 (MDRSPN_01722) - 1713256..1713570 (+) 315 WP_000420682.1 YdcP family protein -
  MDRSPN_RS09045 (MDRSPN_01723) - 1713586..1713972 (+) 387 WP_000985015.1 YdcP family protein -
  MDRSPN_RS09050 (MDRSPN_01724) - 1714001..1715386 (+) 1386 WP_000813488.1 FtsK/SpoIIIE domain-containing protein -
  MDRSPN_RS09055 - 1715389..1715541 (+) 153 WP_000879507.1 hypothetical protein -
  MDRSPN_RS09060 (MDRSPN_01725) mobT 1715564..1716768 (+) 1205 Protein_1715 MobT family relaxase -
  MDRSPN_RS09065 (MDRSPN_01726) - 1716811..1717032 (+) 222 WP_001009056.1 hypothetical protein -
  MDRSPN_RS09070 (MDRSPN_01727) - 1717149..1717646 (+) 498 WP_000342539.1 antirestriction protein ArdA -
  MDRSPN_RS09075 (MDRSPN_01728) - 1717735..1718127 (+) 393 WP_000723888.1 conjugal transfer protein -
  MDRSPN_RS09080 (MDRSPN_01729) - 1718111..1720558 (+) 2448 WP_000331151.1 ATP-binding protein -
  MDRSPN_RS09085 (MDRSPN_01730) - 1720561..1722738 (+) 2178 WP_000804748.1 CD3337/EF1877 family mobilome membrane protein -
  MDRSPN_RS09090 (MDRSPN_01731) - 1722735..1723736 (+) 1002 WP_120164276.1 lysozyme family protein -
  MDRSPN_RS09095 (MDRSPN_01732) - 1723733..1724668 (+) 936 WP_001224320.1 conjugal transfer protein -
  MDRSPN_RS11740 - 1724982..1725029 (+) 48 Protein_1723 hypothetical protein -
  MDRSPN_RS09105 (MDRSPN_01733) tet(M) 1725045..1726964 (+) 1920 WP_049552042.1 tetracycline resistance ribosomal protection protein Tet(M) -
  MDRSPN_RS09110 - 1727083..1727250 (+) 168 WP_000336323.1 cysteine-rich KTR domain-containing protein -
  MDRSPN_RS09115 - 1727310..1727447 (-) 138 Protein_1726 XRE family transcriptional regulator -
  MDRSPN_RS09120 - 1727681..1727764 (+) 84 WP_001865637.1 23S rRNA methyltransferase attenuation leader peptide -
  MDRSPN_RS09125 (MDRSPN_01734) erm(B) 1727889..1728626 (+) 738 WP_001038790.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
  MDRSPN_RS09135 (MDRSPN_01736) - 1728981..1729535 (+) 555 WP_000576156.1 recombinase family protein -
  MDRSPN_RS09140 (MDRSPN_01737) - 1729539..1732457 (+) 2919 WP_001240982.1 Tn3 family transposase -
  MDRSPN_RS09145 (MDRSPN_01738) - 1732531..1732752 (-) 222 Protein_1731 helix-turn-helix domain-containing protein -
  MDRSPN_RS09155 (MDRSPN_01739) - 1733256..1733678 (+) 423 WP_000804885.1 sigma-70 family RNA polymerase sigma factor -
  MDRSPN_RS09160 (MDRSPN_01740) - 1733675..1733905 (+) 231 WP_000857133.1 helix-turn-helix domain-containing protein -
  MDRSPN_RS11380 - 1734131..1734382 (-) 252 WP_001845478.1 hypothetical protein -
  MDRSPN_RS09170 (MDRSPN_01741) - 1734366..1734569 (+) 204 WP_000814511.1 excisionase -
  MDRSPN_RS09175 (MDRSPN_01742) - 1734651..1735868 (+) 1218 WP_001291561.1 tyrosine-type recombinase/integrase -
  MDRSPN_RS09185 (MDRSPN_01743) - 1736759..1738774 (+) 2016 WP_000732395.1 DUF1430 domain-containing protein -
  MDRSPN_RS09190 (MDRSPN_01744) - 1738776..1739408 (+) 633 WP_000571425.1 ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45068.44 Da        Isoelectric Point: 4.8315

>NTDB_id=69338 MDRSPN_RS08995 WP_061588623.1 1707292..1708548(-) (cinA) [Streptococcus pneumoniae strain MDRSPN001]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEARLLSLLEIASQRSNLVILTGGLGPTEDDLTKQT
LAKFLGKELAFDPQSQAKLDVFFAQRPDYARTPNNERQAQLVAGSTPLPNETGLAVGGILEVDGVAYVVLPGPPSELKPM
VLNQLLPKLMTGTKLYSRVLRFFGIGESQLVTILADLIDQQTDPTLAPYAKTGEVTLRLSTKAVSQEKADQVLDILENQI
LDRQTFEGISLRDICYGYGEETSLASVVVEELKKRQKSITAAESLTAGLFQATLADFSGVSAIFNGGFVTYSLEEKSKML
DISEQELKEHGVVSEFTARKMAEQARLKTQSDYGVSLTGVAGPDSLEGHPAGTVFIGLAHAKGTEVIKANIAGRSRADVR
HIAVMHAFNLARKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=69338 MDRSPN_RS08995 WP_061588623.1 1707292..1708548(-) (cinA) [Streptococcus pneumoniae strain MDRSPN001]
ATGAAAGCAGAAATTATTGCTGTTGGAACAGAAATTTTAACAGGGCAAATCGTCAATACCAATGCTCAGTTTTTATCAGA
GAAGCTAGCCGAAATTGGGGTAGATGTCTACTTCCAAACAGCTGTCGGAGACAATGAAGCTCGTCTCTTGTCCTTGCTTG
AGATTGCGAGCCAACGTAGTAATCTTGTGATTTTGACAGGGGGCTTGGGACCAACTGAGGATGATTTGACCAAACAAACT
CTAGCTAAATTTTTAGGGAAAGAATTAGCCTTCGATCCTCAGTCGCAGGCAAAGTTGGATGTCTTTTTTGCTCAGAGACC
AGACTATGCGAGAACACCAAATAATGAAAGACAAGCTCAACTTGTAGCAGGGTCGACTCCACTACCAAACGAAACAGGAT
TGGCTGTTGGAGGAATCTTAGAAGTGGATGGCGTAGCCTACGTGGTCCTTCCGGGACCGCCAAGTGAGTTGAAACCCATG
GTCTTAAATCAACTTTTACCCAAGCTGATGACAGGCACCAAACTATATTCCCGAGTGCTTCGTTTCTTTGGAATTGGTGA
GAGTCAGTTGGTGACCATTTTGGCGGACTTGATTGACCAGCAAACGGATCCGACCTTGGCTCCTTATGCCAAGACGGGAG
AAGTGACTTTGCGCCTGTCTACAAAAGCAGTTAGTCAAGAAAAGGCTGATCAAGTACTAGATATCTTAGAAAATCAAATC
TTGGATCGCCAGACTTTTGAGGGAATTTCTCTGCGCGACATCTGTTATGGATATGGGGAAGAAACCAGCCTCGCAAGTGT
CGTTGTAGAAGAGCTAAAGAAGAGACAGAAAAGCATTACTGCGGCAGAAAGCTTGACGGCAGGTCTCTTTCAGGCTACTT
TAGCAGACTTTTCAGGTGTTTCAGCTATCTTTAATGGAGGGTTTGTCACCTACAGCCTAGAAGAAAAGTCCAAGATGTTG
GATATTTCCGAGCAAGAGCTAAAAGAACACGGGGTCGTTTCTGAGTTTACGGCTCGAAAAATGGCAGAGCAGGCACGGCT
CAAGACTCAGTCTGATTATGGAGTCAGTCTGACAGGTGTAGCTGGGCCAGATAGCCTAGAGGGGCATCCCGCCGGCACAG
TTTTTATTGGACTGGCACATGCAAAAGGGACAGAGGTGATCAAGGCTAATATCGCAGGACGGAGTCGAGCAGATGTACGT
CACATCGCGGTTATGCATGCCTTTAACCTAGCTCGTAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)

Competence-damaged protein (CinA)

(262-414)

Damage-inducible protein CinA KH domain (CinA_KH)

(177-243)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mitis SK321

89.713

100

0.897
  cinA Streptococcus mitis NCTC 12261

89.234

100

0.892
  cinA Streptococcus pneumoniae TIGR4

87.799

100

0.878
  cinA Streptococcus pneumoniae Rx1

87.799

100

0.878
  cinA Streptococcus pneumoniae R6

87.799

100

0.878
  cinA Streptococcus pneumoniae D39

87.56

100

0.876
  cinA Streptococcus mutans UA159

70.096

100

0.701
  cinA Streptococcus suis isolate S10

54.087

99.522

0.538
  cinA Bacillus subtilis subsp. subtilis str. 168

44.976

100

0.45

Multiple sequence alignment