Detailed information
Bioinformatically predicted
Overview
| Name | comM | Type | Regulator |
| Locus tag | MDRSPN_RS09015 | Genome accession | NZ_AP018391 |
| Coordinates | 1710704..1711324 (-) | Length | 206 a.a. |
| NCBI ID | WP_000839909.1 | Uniprot ID | A0A098Z2X2 |
| Organism | Streptococcus pneumoniae strain MDRSPN001 | ||
| Function | fratricide immunity (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1699159..1739809 | 1710704..1711324 | within | 0 |
Gene organization within MGE regions
Location: 1699159..1739809
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MDRSPN_RS08940 (MDRSPN_01706) | - | 1699456..1700007 (-) | 552 | WP_001111247.1 | hypothetical protein | - |
| MDRSPN_RS08945 (MDRSPN_01707) | - | 1699997..1700194 (-) | 198 | WP_000890144.1 | hypothetical protein | - |
| MDRSPN_RS08950 (MDRSPN_01708) | - | 1700198..1700992 (-) | 795 | WP_120164272.1 | hypothetical protein | - |
| MDRSPN_RS08955 (MDRSPN_01709) | - | 1701390..1701815 (-) | 426 | WP_000204070.1 | hypothetical protein | - |
| MDRSPN_RS08960 (MDRSPN_01710) | - | 1701944..1702303 (-) | 360 | WP_000749821.1 | ImmA/IrrE family metallo-endopeptidase | - |
| MDRSPN_RS08965 (MDRSPN_01711) | - | 1702349..1702555 (-) | 207 | WP_000366087.1 | hypothetical protein | - |
| MDRSPN_RS08970 | - | 1702542..1702703 (-) | 162 | WP_000289348.1 | helix-turn-helix domain-containing protein | - |
| MDRSPN_RS08975 (MDRSPN_01712) | lytA | 1703062..1704018 (-) | 957 | WP_120164273.1 | N-acetylmuramoyl-L-alanine amidase LytA | - |
| MDRSPN_RS08980 (MDRSPN_01713) | - | 1704394..1705764 (-) | 1371 | WP_001036271.1 | MATE family efflux transporter | - |
| MDRSPN_RS08990 (MDRSPN_01714) | recA | 1706071..1707237 (-) | 1167 | WP_120164274.1 | recombinase RecA | Machinery gene |
| MDRSPN_RS08995 (MDRSPN_01715) | cinA | 1707292..1708548 (-) | 1257 | WP_061588623.1 | competence/damage-inducible protein A | Machinery gene |
| MDRSPN_RS09000 (MDRSPN_01716) | brpA | 1708622..1709659 (-) | 1038 | WP_120164275.1 | biofilm formation/cell division transcriptional regulator BrpA | - |
| MDRSPN_RS09005 (MDRSPN_01717) | - | 1709667..1710185 (-) | 519 | WP_000455536.1 | GNAT family N-acetyltransferase | - |
| MDRSPN_RS09010 (MDRSPN_01718) | tsaE | 1710175..1710618 (-) | 444 | WP_000288230.1 | tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE | - |
| MDRSPN_RS09015 (MDRSPN_01719) | comM | 1710704..1711324 (-) | 621 | WP_000839909.1 | hypothetical protein | Regulator |
| MDRSPN_RS09025 (MDRSPN_01720) | - | 1711630..1712493 (-) | 864 | WP_001093609.1 | helix-turn-helix domain-containing protein | - |
| MDRSPN_RS11535 (MDRSPN_01721) | - | 1712684..1712854 (+) | 171 | WP_001227863.1 | PhrA family quorum-sensing system peptide | - |
| MDRSPN_RS09040 (MDRSPN_01722) | - | 1713256..1713570 (+) | 315 | WP_000420682.1 | YdcP family protein | - |
| MDRSPN_RS09045 (MDRSPN_01723) | - | 1713586..1713972 (+) | 387 | WP_000985015.1 | YdcP family protein | - |
| MDRSPN_RS09050 (MDRSPN_01724) | - | 1714001..1715386 (+) | 1386 | WP_000813488.1 | FtsK/SpoIIIE domain-containing protein | - |
| MDRSPN_RS09055 | - | 1715389..1715541 (+) | 153 | WP_000879507.1 | hypothetical protein | - |
| MDRSPN_RS09060 (MDRSPN_01725) | mobT | 1715564..1716768 (+) | 1205 | Protein_1715 | MobT family relaxase | - |
| MDRSPN_RS09065 (MDRSPN_01726) | - | 1716811..1717032 (+) | 222 | WP_001009056.1 | hypothetical protein | - |
| MDRSPN_RS09070 (MDRSPN_01727) | - | 1717149..1717646 (+) | 498 | WP_000342539.1 | antirestriction protein ArdA | - |
| MDRSPN_RS09075 (MDRSPN_01728) | - | 1717735..1718127 (+) | 393 | WP_000723888.1 | conjugal transfer protein | - |
| MDRSPN_RS09080 (MDRSPN_01729) | - | 1718111..1720558 (+) | 2448 | WP_000331151.1 | ATP-binding protein | - |
| MDRSPN_RS09085 (MDRSPN_01730) | - | 1720561..1722738 (+) | 2178 | WP_000804748.1 | CD3337/EF1877 family mobilome membrane protein | - |
| MDRSPN_RS09090 (MDRSPN_01731) | - | 1722735..1723736 (+) | 1002 | WP_120164276.1 | lysozyme family protein | - |
| MDRSPN_RS09095 (MDRSPN_01732) | - | 1723733..1724668 (+) | 936 | WP_001224320.1 | conjugal transfer protein | - |
| MDRSPN_RS11740 | - | 1724982..1725029 (+) | 48 | Protein_1723 | hypothetical protein | - |
| MDRSPN_RS09105 (MDRSPN_01733) | tet(M) | 1725045..1726964 (+) | 1920 | WP_049552042.1 | tetracycline resistance ribosomal protection protein Tet(M) | - |
| MDRSPN_RS09110 | - | 1727083..1727250 (+) | 168 | WP_000336323.1 | cysteine-rich KTR domain-containing protein | - |
| MDRSPN_RS09115 | - | 1727310..1727447 (-) | 138 | Protein_1726 | XRE family transcriptional regulator | - |
| MDRSPN_RS09120 | - | 1727681..1727764 (+) | 84 | WP_001865637.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
| MDRSPN_RS09125 (MDRSPN_01734) | erm(B) | 1727889..1728626 (+) | 738 | WP_001038790.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
| MDRSPN_RS09135 (MDRSPN_01736) | - | 1728981..1729535 (+) | 555 | WP_000576156.1 | recombinase family protein | - |
| MDRSPN_RS09140 (MDRSPN_01737) | - | 1729539..1732457 (+) | 2919 | WP_001240982.1 | Tn3 family transposase | - |
| MDRSPN_RS09145 (MDRSPN_01738) | - | 1732531..1732752 (-) | 222 | Protein_1731 | helix-turn-helix domain-containing protein | - |
| MDRSPN_RS09155 (MDRSPN_01739) | - | 1733256..1733678 (+) | 423 | WP_000804885.1 | sigma-70 family RNA polymerase sigma factor | - |
| MDRSPN_RS09160 (MDRSPN_01740) | - | 1733675..1733905 (+) | 231 | WP_000857133.1 | helix-turn-helix domain-containing protein | - |
| MDRSPN_RS11380 | - | 1734131..1734382 (-) | 252 | WP_001845478.1 | hypothetical protein | - |
| MDRSPN_RS09170 (MDRSPN_01741) | - | 1734366..1734569 (+) | 204 | WP_000814511.1 | excisionase | - |
| MDRSPN_RS09175 (MDRSPN_01742) | - | 1734651..1735868 (+) | 1218 | WP_001291561.1 | tyrosine-type recombinase/integrase | - |
| MDRSPN_RS09185 (MDRSPN_01743) | - | 1736759..1738774 (+) | 2016 | WP_000732395.1 | DUF1430 domain-containing protein | - |
| MDRSPN_RS09190 (MDRSPN_01744) | - | 1738776..1739408 (+) | 633 | WP_000571425.1 | ABC transporter ATP-binding protein | - |
Sequence
Protein
Download Length: 206 a.a. Molecular weight: 23540.66 Da Isoelectric Point: 10.1254
>NTDB_id=69339 MDRSPN_RS09015 WP_000839909.1 1710704..1711324(-) (comM) [Streptococcus pneumoniae strain MDRSPN001]
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF
Nucleotide
Download Length: 621 bp
>NTDB_id=69339 MDRSPN_RS09015 WP_000839909.1 1710704..1711324(-) (comM) [Streptococcus pneumoniae strain MDRSPN001]
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATACTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATACTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG
Domains
No domain identified.
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comM | Streptococcus pneumoniae D39 |
99.515 |
100 |
0.995 |
| comM | Streptococcus pneumoniae R6 |
99.515 |
100 |
0.995 |
| comM | Streptococcus pneumoniae TIGR4 |
99.515 |
100 |
0.995 |
| comM | Streptococcus mitis NCTC 12261 |
38.462 |
94.66 |
0.364 |
| comM | Streptococcus mitis SK321 |
38.462 |
94.66 |
0.364 |