Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   H020_RS0109765 Genome accession   NZ_AKVY01000001
Coordinates   1846568..1847824 (-) Length   418 a.a.
NCBI ID   WP_000642718.1    Uniprot ID   P54184
Organism   Streptococcus pneumoniae TIGR4     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1839466..1861657 1846568..1847824 within 0


Gene organization within MGE regions


Location: 1839466..1861657
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H020_RS0109725 - 1839466..1840260 (-) 795 WP_001101210.1 hypothetical protein -
  H020_RS0109730 - 1840668..1841093 (-) 426 WP_000204063.1 hypothetical protein -
  H020_RS0109735 - 1841222..1841581 (-) 360 WP_000749819.1 ImmA/IrrE family metallo-endopeptidase -
  H020_RS0109740 - 1841627..1841833 (-) 207 WP_000366093.1 hypothetical protein -
  H020_RS0109745 - 1841820..1841981 (-) 162 WP_000289348.1 helix-turn-helix domain-containing protein -
  H020_RS0109750 lytA 1842339..1843295 (-) 957 WP_000405234.1 N-acetylmuramoyl-L-alanine amidase LytA -
  H020_RS0109755 - 1843671..1845041 (-) 1371 WP_001036271.1 MATE family efflux transporter -
  H020_RS0109760 recA 1845347..1846513 (-) 1167 WP_001085462.1 recombinase RecA Machinery gene
  H020_RS0109765 cinA 1846568..1847824 (-) 1257 WP_000642718.1 competence/damage-inducible protein A Machinery gene
  H020_RS0109770 brpA 1847909..1848925 (-) 1017 WP_000239283.1 biofilm formation/cell division transcriptional regulator BrpA -
  H020_RS0109775 - 1848933..1849451 (-) 519 WP_000455537.1 GNAT family N-acetyltransferase -
  H020_RS0109780 tsaE 1849441..1849884 (-) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  H020_RS0109785 comM 1849970..1850590 (-) 621 WP_000839908.1 hypothetical protein Regulator
  H020_RS0109790 - 1850973..1851836 (-) 864 WP_001093641.1 helix-turn-helix domain-containing protein -
  H020_RS14570 - 1852028..1852198 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  H020_RS0109800 pneA1 1852301..1852525 (+) 225 WP_000181087.1 two-peptide bacteriocin subunit PneA1 -
  H020_RS0109805 pneA2 1852532..1852720 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  H020_RS0109810 - 1852836..1855826 (+) 2991 WP_000875573.1 type 2 lanthipeptide synthetase LanM family protein -
  H020_RS0109815 - 1856176..1856880 (+) 705 WP_001033170.1 flavodoxin family protein -
  H020_RS0109820 - 1856861..1857790 (+) 930 WP_000912954.1 M50 family metallopeptidase -
  H020_RS0109825 - 1857787..1859895 (+) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  H020_RS0109830 - 1859919..1861331 (+) 1413 WP_000699968.1 S8 family peptidase -
  H020_RS14410 - 1861385..1861657 (+) 273 WP_000939671.1 hypothetical protein -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45091.48 Da        Isoelectric Point: 4.6027

>NTDB_id=64954 H020_RS0109765 WP_000642718.1 1846568..1847824(-) (cinA) [Streptococcus pneumoniae TIGR4]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFTLRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFKGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=64954 H020_RS0109765 WP_000642718.1 1846568..1847824(-) (cinA) [Streptococcus pneumoniae TIGR4]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGGCAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTACCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTAAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGATCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(262-414)

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P54184

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae TIGR4

100

100

1
  cinA Streptococcus pneumoniae Rx1

99.282

100

0.993
  cinA Streptococcus pneumoniae R6

99.282

100

0.993
  cinA Streptococcus pneumoniae D39

99.043

100

0.99
  cinA Streptococcus mitis SK321

93.541

100

0.935
  cinA Streptococcus mitis NCTC 12261

93.301

100

0.933
  cinA Streptococcus mutans UA159

70.813

100

0.708
  cinA Streptococcus suis isolate S10

54.808

99.522

0.545
  cinA Bacillus subtilis subsp. subtilis str. 168

45.455

100

0.455

Multiple sequence alignment