Detailed information    

insolico Bioinformatically predicted

Overview

Name   comM   Type   Regulator
Locus tag   H020_RS0109785 Genome accession   NZ_AKVY01000001
Coordinates   1849970..1850590 (-) Length   206 a.a.
NCBI ID   WP_000839908.1    Uniprot ID   A0A0B7M636
Organism   Streptococcus pneumoniae TIGR4     
Function   fratricide immunity (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1839466..1861657 1849970..1850590 within 0


Gene organization within MGE regions


Location: 1839466..1861657
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H020_RS0109725 - 1839466..1840260 (-) 795 WP_001101210.1 hypothetical protein -
  H020_RS0109730 - 1840668..1841093 (-) 426 WP_000204063.1 hypothetical protein -
  H020_RS0109735 - 1841222..1841581 (-) 360 WP_000749819.1 ImmA/IrrE family metallo-endopeptidase -
  H020_RS0109740 - 1841627..1841833 (-) 207 WP_000366093.1 hypothetical protein -
  H020_RS0109745 - 1841820..1841981 (-) 162 WP_000289348.1 helix-turn-helix domain-containing protein -
  H020_RS0109750 lytA 1842339..1843295 (-) 957 WP_000405234.1 N-acetylmuramoyl-L-alanine amidase LytA -
  H020_RS0109755 - 1843671..1845041 (-) 1371 WP_001036271.1 MATE family efflux transporter -
  H020_RS0109760 recA 1845347..1846513 (-) 1167 WP_001085462.1 recombinase RecA Machinery gene
  H020_RS0109765 cinA 1846568..1847824 (-) 1257 WP_000642718.1 competence/damage-inducible protein A Machinery gene
  H020_RS0109770 brpA 1847909..1848925 (-) 1017 WP_000239283.1 biofilm formation/cell division transcriptional regulator BrpA -
  H020_RS0109775 - 1848933..1849451 (-) 519 WP_000455537.1 GNAT family N-acetyltransferase -
  H020_RS0109780 tsaE 1849441..1849884 (-) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  H020_RS0109785 comM 1849970..1850590 (-) 621 WP_000839908.1 hypothetical protein Regulator
  H020_RS0109790 - 1850973..1851836 (-) 864 WP_001093641.1 helix-turn-helix domain-containing protein -
  H020_RS14570 - 1852028..1852198 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  H020_RS0109800 pneA1 1852301..1852525 (+) 225 WP_000181087.1 two-peptide bacteriocin subunit PneA1 -
  H020_RS0109805 pneA2 1852532..1852720 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  H020_RS0109810 - 1852836..1855826 (+) 2991 WP_000875573.1 type 2 lanthipeptide synthetase LanM family protein -
  H020_RS0109815 - 1856176..1856880 (+) 705 WP_001033170.1 flavodoxin family protein -
  H020_RS0109820 - 1856861..1857790 (+) 930 WP_000912954.1 M50 family metallopeptidase -
  H020_RS0109825 - 1857787..1859895 (+) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  H020_RS0109830 - 1859919..1861331 (+) 1413 WP_000699968.1 S8 family peptidase -
  H020_RS14410 - 1861385..1861657 (+) 273 WP_000939671.1 hypothetical protein -

Sequence

Protein


Download         Length: 206 a.a.        Molecular weight: 23552.72 Da        Isoelectric Point: 10.1254

>NTDB_id=64955 H020_RS0109785 WP_000839908.1 1849970..1850590(-) (comM) [Streptococcus pneumoniae TIGR4]
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF

Nucleotide


Download         Length: 621 bp        

>NTDB_id=64955 H020_RS0109785 WP_000839908.1 1849970..1850590(-) (comM) [Streptococcus pneumoniae TIGR4]
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTGGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATATTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7M636

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comM Streptococcus pneumoniae D39

100

100

1
  comM Streptococcus pneumoniae R6

100

100

1
  comM Streptococcus pneumoniae TIGR4

100

100

1
  comM Streptococcus mitis NCTC 12261

38.974

94.66

0.369
  comM Streptococcus mitis SK321

38.974

94.66

0.369

Multiple sequence alignment