Detailed information NTG0639377

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: LXA46_RS10830
• Genome accession: NZ_CP089948
• Coordinates: 2148476..2149228 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae TIGR4
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2143476..2154228

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LXA46_RS10810 (LXA46_10795)	-	2145910..2147512 (-)	1603	Protein_2124	YhgE/Pip domain-containing protein	-
LXA46_RS10815 (LXA46_10800)	-	2147691..2148233 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
LXA46_RS10830 (LXA46_10815)	comE	2148476..2149228 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
LXA46_RS10835 (LXA46_10820)	comD/comD2	2149225..2150550 (-)	1326	WP_000364845.1	competence system sensor histidine kinase ComD	Regulator
LXA46_RS10840 (LXA46_10825)	comC/comC2	2150571..2150696 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
LXA46_RS10850 (LXA46_10835)	rlmH	2150978..2151457 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
LXA46_RS10855 (LXA46_10840)	htrA	2151640..2152821 (+)	1182	WP_000681597.1	trypsin-like peptidase domain-containing protein	Regulator
LXA46_RS10860 (LXA46_10845)	spo0J	2152879..2153637 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=639377 LXA46_RS10830 WP_000866065.1 2148476..2149228(-) (comE) [Streptococcus pneumoniae TIGR4]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=639377 LXA46_RS10830 WP_000866065.1 2148476..2149228(-) (comE) [Streptococcus pneumoniae TIGR4]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGTAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408