Detailed information NTG0602561

Bioinformatically predicted

Overview

• Name: cinA
• Type: Machinery gene
• Locus tag: K8B76_RS08830
• Genome accession: NZ_CP082820
• Coordinates: 1765749..1767005 (-)
• Length: 418 a.a.
• NCBI ID: WP_000642706.1
• Uniprot ID: A0A098Z3K2
• Organism: Streptococcus pneumoniae strain SCAID PHRX1-2021
• Function: facilitate localization of RecA (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	1758633..1780892	1765749..1767005	within	0

Gene organization within MGE regions

Location: 1758633..1780892

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K8B76_RS08790 (K8B76_08790)	-	1758633..1759427 (-)	795	WP_001101210.1	hypothetical protein	-
K8B76_RS08795 (K8B76_08795)	-	1759835..1760260 (-)	426	WP_000204065.1	hypothetical protein	-
K8B76_RS08800 (K8B76_08800)	-	1760389..1760748 (-)	360	WP_000749822.1	ImmA/IrrE family metallo-endopeptidase	-
K8B76_RS08805 (K8B76_08805)	-	1760794..1761000 (-)	207	WP_000366091.1	hypothetical protein	-
K8B76_RS08810 (K8B76_08810)	-	1760987..1761160 (-)	174	WP_000289349.1	helix-turn-helix domain-containing protein	-
K8B76_RS08815 (K8B76_08815)	lytA	1761519..1762475 (-)	957	WP_000405235.1	N-acetylmuramoyl-L-alanine amidase LytA	-
K8B76_RS08820 (K8B76_08820)	-	1762851..1764221 (-)	1371	WP_001036271.1	MATE family efflux transporter	-
K8B76_RS08825 (K8B76_08825)	recA	1764528..1765694 (-)	1167	WP_001085462.1	recombinase RecA	Machinery gene
K8B76_RS08830 (K8B76_08830)	cinA	1765749..1767005 (-)	1257	WP_000642706.1	competence/damage-inducible protein A	Machinery gene
K8B76_RS08835 (K8B76_08835)	brpA	1767090..1768106 (-)	1017	WP_000239282.1	biofilm formation/cell division transcriptional regulator BrpA	-
K8B76_RS08840 (K8B76_08840)	-	1768114..1768632 (-)	519	WP_000455537.1	GNAT family N-acetyltransferase	-
K8B76_RS08845 (K8B76_08845)	tsaE	1768622..1769065 (-)	444	WP_000288232.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE	-
K8B76_RS08850 (K8B76_08850)	comM	1769282..1769902 (-)	621	WP_084572333.1	hypothetical protein	Regulator
K8B76_RS08855 (K8B76_08855)	-	1770208..1771071 (-)	864	WP_001093641.1	helix-turn-helix domain-containing protein	-
K8B76_RS10880	-	1771263..1771433 (+)	171	WP_001227862.1	PhrA family quorum-sensing system peptide	-
K8B76_RS08860 (K8B76_08860)	pneA1	1771536..1771760 (+)	225	WP_000181087.1	two-peptide bacteriocin subunit PneA1	-
K8B76_RS08865 (K8B76_08865)	pneA2	1771767..1771955 (+)	189	WP_000786759.1	two-peptide bacteriocin subunit PneA2	-
K8B76_RS08870 (K8B76_08870)	-	1772070..1775060 (+)	2991	WP_000875573.1	type 2 lanthipeptide synthetase LanM family protein	-
K8B76_RS08875 (K8B76_08875)	-	1775410..1776114 (+)	705	WP_001033170.1	flavodoxin family protein	-
K8B76_RS08880 (K8B76_08880)	-	1776095..1777024 (+)	930	WP_000912954.1	M50 family metallopeptidase	-
K8B76_RS08885 (K8B76_08885)	-	1777021..1779129 (+)	2109	WP_000701298.1	peptidase domain-containing ABC transporter	-
K8B76_RS08890 (K8B76_08890)	-	1779153..1780892 (+)	1740	WP_000699969.1	S8 family serine peptidase	-

Sequence

Protein

• Length: 418 a.a.
• Molecular weight: 45062.40 Da
• Isoelectric Point: 4.5211

>NTDB_id=602561 K8B76_RS08830 WP_000642706.1 1765749..1767005(-) (cinA) [Streptococcus pneumoniae strain SCAID PHRX1-2021]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFEGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide

• Length: 1257 bp

>NTDB_id=602561 K8B76_RS08830 WP_000642706.1 1765749..1767005(-) (cinA) [Streptococcus pneumoniae strain SCAID PHRX1-2021]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTGAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGATCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

• Damage-inducible protein CinA KH domain (CinA_KH) (177-240)

• Probable molybdopterin binding domain (MoCF_biosynth) (5-169)

• Competence-damaged protein (CinA) (262-414)

3D structure

• AlphaFold DB: A0A098Z3K2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cinA	Streptococcus pneumoniae Rx1	99.761	100	0.998
cinA	Streptococcus pneumoniae R6	99.761	100	0.998
cinA	Streptococcus pneumoniae TIGR4	99.522	100	0.995
cinA	Streptococcus pneumoniae D39	99.522	100	0.995
cinA	Streptococcus mitis SK321	93.541	100	0.935
cinA	Streptococcus mitis NCTC 12261	93.301	100	0.933
cinA	Streptococcus mutans UA159	70.813	100	0.708
cinA	Streptococcus suis isolate S10	55.048	99.522	0.548
cinA	Bacillus subtilis subsp. subtilis str. 168	45.455	100	0.455