Detailed information    

insolico Bioinformatically predicted

Overview

Name   comM   Type   Regulator
Locus tag   K8B76_RS08850 Genome accession   NZ_CP082820
Coordinates   1769282..1769902 (-) Length   206 a.a.
NCBI ID   WP_084572333.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain SCAID PHRX1-2021     
Function   fratricide immunity (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1758633..1780892 1769282..1769902 within 0


Gene organization within MGE regions


Location: 1758633..1780892
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  K8B76_RS08790 (K8B76_08790) - 1758633..1759427 (-) 795 WP_001101210.1 hypothetical protein -
  K8B76_RS08795 (K8B76_08795) - 1759835..1760260 (-) 426 WP_000204065.1 hypothetical protein -
  K8B76_RS08800 (K8B76_08800) - 1760389..1760748 (-) 360 WP_000749822.1 ImmA/IrrE family metallo-endopeptidase -
  K8B76_RS08805 (K8B76_08805) - 1760794..1761000 (-) 207 WP_000366091.1 hypothetical protein -
  K8B76_RS08810 (K8B76_08810) - 1760987..1761160 (-) 174 WP_000289349.1 helix-turn-helix domain-containing protein -
  K8B76_RS08815 (K8B76_08815) lytA 1761519..1762475 (-) 957 WP_000405235.1 N-acetylmuramoyl-L-alanine amidase LytA -
  K8B76_RS08820 (K8B76_08820) - 1762851..1764221 (-) 1371 WP_001036271.1 MATE family efflux transporter -
  K8B76_RS08825 (K8B76_08825) recA 1764528..1765694 (-) 1167 WP_001085462.1 recombinase RecA Machinery gene
  K8B76_RS08830 (K8B76_08830) cinA 1765749..1767005 (-) 1257 WP_000642706.1 competence/damage-inducible protein A Machinery gene
  K8B76_RS08835 (K8B76_08835) brpA 1767090..1768106 (-) 1017 WP_000239282.1 biofilm formation/cell division transcriptional regulator BrpA -
  K8B76_RS08840 (K8B76_08840) - 1768114..1768632 (-) 519 WP_000455537.1 GNAT family N-acetyltransferase -
  K8B76_RS08845 (K8B76_08845) tsaE 1768622..1769065 (-) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  K8B76_RS08850 (K8B76_08850) comM 1769282..1769902 (-) 621 WP_084572333.1 hypothetical protein Regulator
  K8B76_RS08855 (K8B76_08855) - 1770208..1771071 (-) 864 WP_001093641.1 helix-turn-helix domain-containing protein -
  K8B76_RS10880 - 1771263..1771433 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  K8B76_RS08860 (K8B76_08860) pneA1 1771536..1771760 (+) 225 WP_000181087.1 two-peptide bacteriocin subunit PneA1 -
  K8B76_RS08865 (K8B76_08865) pneA2 1771767..1771955 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  K8B76_RS08870 (K8B76_08870) - 1772070..1775060 (+) 2991 WP_000875573.1 type 2 lanthipeptide synthetase LanM family protein -
  K8B76_RS08875 (K8B76_08875) - 1775410..1776114 (+) 705 WP_001033170.1 flavodoxin family protein -
  K8B76_RS08880 (K8B76_08880) - 1776095..1777024 (+) 930 WP_000912954.1 M50 family metallopeptidase -
  K8B76_RS08885 (K8B76_08885) - 1777021..1779129 (+) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  K8B76_RS08890 (K8B76_08890) - 1779153..1780892 (+) 1740 WP_000699969.1 S8 family serine peptidase -

Sequence

Protein


Download         Length: 206 a.a.        Molecular weight: 23485.63 Da        Isoelectric Point: 10.0081

>NTDB_id=602562 K8B76_RS08850 WP_084572333.1 1769282..1769902(-) (comM) [Streptococcus pneumoniae strain SCAID PHRX1-2021]
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYIHDLLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIATLIFF

Nucleotide


Download         Length: 621 bp        

>NTDB_id=602562 K8B76_RS08850 WP_084572333.1 1769282..1769902(-) (comM) [Streptococcus pneumoniae strain SCAID PHRX1-2021]
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAAGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGTATGGTCTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCAGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTATTAGGAGCTGTCCTTGTCTTGTCAGATAACTTGTTCATTAAAAATACGTTGCAGCAAGAATTAGTTGACTT
TTTGTTGCCATCCTTTTTCTTTCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACATACACGATTTGC
TTGCTATGCTAGATAGAAAAAAGACGGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATATTGGACTGGGCTTGTTCTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGCTACGCTCATTTTCTTTTAG

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comM Streptococcus pneumoniae D39

98.058

100

0.981
  comM Streptococcus pneumoniae R6

98.058

100

0.981
  comM Streptococcus pneumoniae TIGR4

98.058

100

0.981
  comM Streptococcus mitis SK321

38.974

94.66

0.369
  comM Streptococcus mitis NCTC 12261

38.462

94.66

0.364