Detailed information NTG0572234

Bioinformatically predicted

Overview

• Name: comGA
• Type: Machinery gene
• Locus tag: MN088_RS11495
• Genome accession: NZ_CP093413
• Coordinates: 2243564..2244502 (-)
• Length: 312 a.a.
• NCBI ID: WP_010906320.1
• Uniprot ID: Q9CDT8
• Organism: Lactococcus lactis strain AH1
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 2238564..2249502

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MN088_RS11460 (MN088_11460)	-	2238859..2239092 (-)	234	WP_014570819.1	transcriptional regulator	-
MN088_RS11465 (MN088_11465)	-	2239299..2239679 (+)	381	WP_031561101.1	XRE family transcriptional regulator	-
MN088_RS11470 (MN088_11470)	-	2239690..2240274 (+)	585	WP_058221714.1	hypothetical protein	-
MN088_RS11475 (MN088_11475)	-	2240330..2240869 (+)	540	WP_023189015.1	PH domain-containing protein	-
MN088_RS11480 (MN088_11480)	-	2240989..2242446 (+)	1458	WP_031561103.1	recombinase family protein	-
MN088_RS11485 (MN088_11485)	-	2242443..2242583 (-)	141	WP_023164653.1	hypothetical protein	-
MN088_RS11490 (MN088_11490)	comGB	2242597..2243670 (-)	1074	WP_010906319.1	competence type IV pilus assembly protein ComGB	Machinery gene
MN088_RS11495 (MN088_11495)	comGA	2243564..2244502 (-)	939	WP_010906320.1	competence type IV pilus ATPase ComGA	Machinery gene

Sequence

Protein

• Length: 312 a.a.
• Molecular weight: 35719.89 Da
• Isoelectric Point: 6.1804

>NTDB_id=572234 MN088_RS11495 WP_010906320.1 2243564..2244502(-) (comGA) [Lactococcus lactis strain AH1]
MIPKMAKELIQRAIDRDASDIYLIASKEKYKLYFRQMTARDLVEEIGLEVGLALLTHFKFLAGMNTGERRRVQLGACWYE
IEESNAKRLRLSTVGDFEGNESLVIRLLHDQNKELDFWFDQELENYDCKRGLHLFAGPVGSGKTSLMFDLARRHFTDLQV
INIEEPVELIDSDFIQLQVNEVIGNSYDELIKLSLRHRPDLLIVGEIRDKLTAQAVLRASLTGYTVFSTVHASSVRGVIQ
RLSELGLSHWEIKNALSSVVYQRLIAGKGVLDIAKNEFESWSSENWNKKIDQLLTNGYLTPTEAKREKIKTD

Nucleotide

• Length: 939 bp

>NTDB_id=572234 MN088_RS11495 WP_010906320.1 2243564..2244502(-) (comGA) [Lactococcus lactis strain AH1]
ATGATACCAAAAATGGCAAAAGAATTAATTCAAAGAGCAATTGATAGAGATGCATCAGATATTTATCTGATTGCTTCAAA
AGAAAAGTATAAACTTTATTTTCGACAAATGACAGCACGTGATCTGGTAGAAGAAATTGGGTTAGAAGTTGGCTTAGCAC
TACTTACTCACTTTAAGTTTCTAGCTGGGATGAATACAGGAGAACGCAGACGAGTTCAATTGGGAGCTTGTTGGTATGAA
ATAGAGGAAAGTAATGCAAAACGTTTGCGTCTTTCGACAGTGGGGGATTTCGAGGGTAATGAATCTTTAGTAATACGTCT
CTTGCATGATCAAAACAAAGAACTTGATTTTTGGTTTGATCAAGAGCTAGAGAATTATGATTGTAAAAGAGGATTGCATC
TCTTTGCCGGTCCAGTAGGCTCGGGAAAAACATCTTTAATGTTTGATTTAGCTCGTCGTCATTTTACAGATTTACAAGTT
ATCAATATAGAAGAACCCGTTGAGTTGATTGATTCCGATTTTATTCAGTTACAAGTCAACGAAGTCATTGGTAATAGTTA
TGATGAATTAATTAAATTATCACTGAGGCATCGCCCAGATTTGTTAATCGTTGGTGAAATTCGTGATAAATTGACCGCTC
AAGCAGTTTTACGGGCTAGTTTGACAGGTTATACAGTGTTTTCAACCGTTCATGCCTCTTCTGTTAGAGGTGTCATTCAG
AGATTATCAGAGCTGGGTTTAAGTCATTGGGAAATAAAAAATGCTTTATCAAGTGTTGTTTATCAGCGTTTAATAGCTGG
GAAAGGAGTATTAGACATTGCCAAAAACGAATTTGAGTCTTGGTCATCAGAAAATTGGAATAAAAAAATTGATCAGCTAC
TTACAAATGGATATCTCACACCTACTGAAGCCAAAAGGGAAAAAATTAAGACTGATTAA

Domains

Predicted by InterProScan.

• Type II/IV secretion system protein (T2SSE) (9-265)

3D structure

• AlphaFold DB: Q9CDT8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comGA	Lactococcus lactis subsp. cremoris KW2	76.603	100	0.766
comGA/cglA	Streptococcus sobrinus strain NIDR 6715-7	54.662	99.679	0.545
comGA/cglA/cilD	Streptococcus mitis NCTC 12261	53.055	99.679	0.529
comGA/cglA/cilD	Streptococcus pneumoniae Rx1	52.09	99.679	0.519
comGA/cglA/cilD	Streptococcus pneumoniae D39	52.09	99.679	0.519
comGA/cglA/cilD	Streptococcus pneumoniae R6	52.09	99.679	0.519
comGA/cglA/cilD	Streptococcus pneumoniae TIGR4	52.09	99.679	0.519
comGA	Streptococcus gordonii str. Challis substr. CH1	51.923	100	0.519
comGA	Streptococcus mutans UA140	51.923	100	0.519
comGA	Streptococcus mutans UA159	51.923	100	0.519