Detailed information NTG0549073

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: J4Q30_RS11495
• Genome accession: NZ_CP071917
• Coordinates: 2191292..2192044 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 19A-19339
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2186292..2197044

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
J4Q30_RS11465 (J4Q30_11465)	-	2186671..2189223 (+)	2553	WP_219589546.1	YfhO family protein	-
J4Q30_RS11800 (J4Q30_11470)	-	2189253..2190400 (-)	1148	Protein_2249	YhgE/Pip family protein	-
J4Q30_RS11480 (J4Q30_11475)	-	2190507..2191049 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
J4Q30_RS11495 (J4Q30_11490)	comE	2191292..2192044 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
J4Q30_RS11500 (J4Q30_11495)	comD/comD1	2192041..2193366 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
J4Q30_RS11505 (J4Q30_11500)	comC/comC1	2193387..2193512 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
J4Q30_RS11515 (J4Q30_11510)	rlmH	2193794..2194273 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
J4Q30_RS11520 (J4Q30_11515)	htrA	2194456..2195637 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
J4Q30_RS11525 (J4Q30_11520)	spo0J	2195695..2196453 (+)	759	WP_000410376.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=549073 J4Q30_RS11495 WP_000866065.1 2191292..2192044(-) (comE) [Streptococcus pneumoniae strain 19A-19339]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=549073 J4Q30_RS11495 WP_000866065.1 2191292..2192044(-) (comE) [Streptococcus pneumoniae strain 19A-19339]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408