Detailed information NTG0549076

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: J4Q30_RS11520
• Genome accession: NZ_CP071917
• Coordinates: 2194456..2195637 (+)
• Length: 393 a.a.
• NCBI ID: WP_000681597.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 19A-19339
• Function: degrading CSP; selective degradation of ComEA and ComEC (predicted from homology) Competence regulation

Genomic Context

Location: 2189456..2200637

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
J4Q30_RS11480 (J4Q30_11475)	-	2190507..2191049 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
J4Q30_RS11495 (J4Q30_11490)	comE	2191292..2192044 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
J4Q30_RS11500 (J4Q30_11495)	comD/comD1	2192041..2193366 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
J4Q30_RS11505 (J4Q30_11500)	comC/comC1	2193387..2193512 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
J4Q30_RS11515 (J4Q30_11510)	rlmH	2193794..2194273 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
J4Q30_RS11520 (J4Q30_11515)	htrA	2194456..2195637 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
J4Q30_RS11525 (J4Q30_11520)	spo0J	2195695..2196453 (+)	759	WP_000410376.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41841.72 Da
• Isoelectric Point: 6.8902

>NTDB_id=549076 J4Q30_RS11520 WP_000681597.1 2194456..2195637(+) (htrA) [Streptococcus pneumoniae strain 19A-19339]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVI
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=549076 J4Q30_RS11520 WP_000681597.1 2194456..2195637(+) (htrA) [Streptococcus pneumoniae strain 19A-19339]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAAATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAATT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (289-384)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus pneumoniae Rx1	100	100	1
htrA	Streptococcus pneumoniae D39	100	100	1
htrA	Streptococcus pneumoniae R6	100	100	1
htrA	Streptococcus pneumoniae TIGR4	100	100	1
htrA	Streptococcus mitis NCTC 12261	97.201	100	0.972
htrA	Streptococcus gordonii str. Challis substr. CH1	66.414	100	0.669
htrA	Streptococcus mutans UA159	54.569	100	0.547