Detailed information NTG0548664

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: JN057_RS11020
• Genome accession: NZ_CP071871
• Coordinates: 2129295..2130047 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain BVJ1JL
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2124295..2135047

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JN057_RS11615	-	2126728..2128331 (-)	1604	Protein_2145	YhgE/Pip family protein	-
JN057_RS11005 (JN057_02254)	-	2128510..2129052 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
JN057_RS11020 (JN057_02257)	comE	2129295..2130047 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
JN057_RS11025 (JN057_02258)	comD/comD1	2130044..2131369 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
JN057_RS11030 (JN057_02259)	comC/comC1	2131390..2131515 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
JN057_RS11040 (JN057_02261)	rlmH	2131797..2132276 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
JN057_RS11045 (JN057_02262)	htrA	2132459..2133640 (+)	1182	WP_000681603.1	S1C family serine protease	Regulator
JN057_RS11050 (JN057_02263)	spo0J	2133698..2134456 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=548664 JN057_RS11020 WP_000866065.1 2129295..2130047(-) (comE) [Streptococcus pneumoniae strain BVJ1JL]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=548664 JN057_RS11020 WP_000866065.1 2129295..2130047(-) (comE) [Streptococcus pneumoniae strain BVJ1JL]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACATATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408