Detailed information NTG0548667

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: JN057_RS11045
• Genome accession: NZ_CP071871
• Coordinates: 2132459..2133640 (+)
• Length: 393 a.a.
• NCBI ID: WP_000681603.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain BVJ1JL
• Function: degrading CSP; selective degradation of ComEA and ComEC (predicted from homology) Competence regulation

Genomic Context

Location: 2127459..2138640

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JN057_RS11005 (JN057_02254)	-	2128510..2129052 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
JN057_RS11020 (JN057_02257)	comE	2129295..2130047 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
JN057_RS11025 (JN057_02258)	comD/comD1	2130044..2131369 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
JN057_RS11030 (JN057_02259)	comC/comC1	2131390..2131515 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
JN057_RS11040 (JN057_02261)	rlmH	2131797..2132276 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
JN057_RS11045 (JN057_02262)	htrA	2132459..2133640 (+)	1182	WP_000681603.1	S1C family serine protease	Regulator
JN057_RS11050 (JN057_02263)	spo0J	2133698..2134456 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41840.78 Da
• Isoelectric Point: 8.2517

>NTDB_id=548667 JN057_RS11045 WP_000681603.1 2132459..2133640(+) (htrA) [Streptococcus pneumoniae strain BVJ1JL]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGKIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVI
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=548667 JN057_RS11045 WP_000681603.1 2132459..2133640(+) (htrA) [Streptococcus pneumoniae strain BVJ1JL]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAAAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAAATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAATT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (289-384)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus pneumoniae Rx1	99.746	100	0.997
htrA	Streptococcus pneumoniae D39	99.746	100	0.997
htrA	Streptococcus pneumoniae R6	99.746	100	0.997
htrA	Streptococcus pneumoniae TIGR4	99.746	100	0.997
htrA	Streptococcus mitis NCTC 12261	96.947	100	0.969
htrA	Streptococcus gordonii str. Challis substr. CH1	66.162	100	0.667
htrA	Streptococcus mutans UA159	54.822	100	0.55