Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYA   Type   Machinery gene
Locus tag   I6J12_RS10935 Genome accession   NZ_CP068060
Coordinates   2248588..2249529 (+) Length   313 a.a.
NCBI ID   WP_003033431.1    Uniprot ID   I0SLG1
Organism   Streptococcus anginosus strain FDAARGOS_1155     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 2243588..2254529
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6J12_RS10910 (I6J12_10910) - 2243899..2245098 (+) 1200 WP_003033487.1 phosphoglycerate kinase -
  I6J12_RS10915 (I6J12_10915) - 2245613..2246143 (+) 531 WP_003033434.1 FUSC family protein -
  I6J12_RS10920 (I6J12_10920) - 2246220..2246579 (+) 360 WP_003028467.1 MerR family transcriptional regulator -
  I6J12_RS10925 (I6J12_10925) glnA 2246618..2247964 (+) 1347 WP_003033463.1 type I glutamate--ammonia ligase -
  I6J12_RS10930 (I6J12_10930) - 2248153..2248518 (+) 366 WP_003033468.1 DUF1033 family protein -
  I6J12_RS10935 (I6J12_10935) comYA 2248588..2249529 (+) 942 WP_003033431.1 competence type IV pilus ATPase ComGA Machinery gene
  I6J12_RS10940 (I6J12_10940) comYB 2249471..2250493 (+) 1023 WP_020999446.1 competence type IV pilus assembly protein ComGB Machinery gene
  I6J12_RS10945 (I6J12_10945) - 2250571..2252010 (-) 1440 WP_003038160.1 recombinase family protein -
  I6J12_RS10950 (I6J12_10950) - 2252188..2252403 (-) 216 WP_003038243.1 hypothetical protein -
  I6J12_RS10955 (I6J12_10955) - 2252454..2253188 (-) 735 WP_003038240.1 helix-turn-helix domain-containing protein -
  I6J12_RS10960 (I6J12_10960) - 2253345..2253548 (+) 204 WP_003038241.1 helix-turn-helix transcriptional regulator -
  I6J12_RS10965 (I6J12_10965) - 2253684..2253830 (+) 147 WP_003038244.1 BOW99_gp33 family protein -
  I6J12_RS10970 (I6J12_10970) - 2253870..2254202 (+) 333 WP_003038177.1 hypothetical protein -

Sequence

Protein


Download         Length: 313 a.a.        Molecular weight: 35955.09 Da        Isoelectric Point: 6.2451

>NTDB_id=526826 I6J12_RS10935 WP_003033431.1 2248588..2249529(+) (comYA) [Streptococcus anginosus strain FDAARGOS_1155]
MVQNIAQAIICQAKEERAQDIYFVPKENVYELYMRIGDERRFIRNYEFEELAAVISHFKFTAGMNVGEKRRSQLGSCDYQ
YGDKKTSLRLSTVGDYRGYESLVIRLLHDEEAELKFWYTQIPELKERFKQRGLYLFSGPVGSGKTTLMHQLAQERFADQQ
IMSIEDPVEIKQSGMLQLQLNEAIGLTYESLIKLSLRHRPDLLIIGEIRDAETARAVVRASLTGVTVFSTIHAKSVRGVY
ERLLELGVTEAELKVVLQGICYQRLIAKGGIVDFVSERYQEHEPIDWNRQIDQLHAAGHINLEQAESEKIIHG

Nucleotide


Download         Length: 942 bp        

>NTDB_id=526826 I6J12_RS10935 WP_003033431.1 2248588..2249529(+) (comYA) [Streptococcus anginosus strain FDAARGOS_1155]
ATGGTTCAAAACATTGCACAGGCTATTATTTGTCAGGCTAAGGAAGAACGAGCACAGGACATTTATTTTGTTCCGAAGGA
AAATGTTTACGAGTTGTATATGCGAATTGGAGATGAACGCCGTTTTATACGCAATTATGAATTTGAAGAGCTAGCTGCTG
TAATCAGTCATTTCAAGTTTACCGCTGGGATGAATGTCGGCGAAAAACGTAGAAGCCAGCTAGGATCTTGTGATTATCAA
TATGGTGATAAGAAAACGTCATTACGACTGTCAACAGTGGGGGATTATCGCGGATATGAAAGTCTAGTGATTCGTCTATT
GCATGATGAAGAAGCAGAGTTGAAGTTTTGGTATACTCAGATTCCAGAGCTGAAAGAACGTTTCAAACAGCGAGGACTTT
ACCTTTTTTCAGGACCGGTAGGAAGTGGAAAAACGACTCTCATGCACCAGTTGGCTCAAGAGCGTTTTGCCGATCAGCAA
ATCATGTCCATTGAAGACCCTGTTGAAATCAAGCAGTCTGGCATGTTACAGCTGCAACTGAACGAAGCGATTGGTTTAAC
TTATGAAAGTTTGATTAAACTTTCTCTTCGGCATCGACCAGATTTATTGATTATCGGAGAGATTCGTGATGCGGAGACAG
CACGGGCAGTTGTTCGAGCTAGCTTGACAGGAGTGACTGTCTTTTCAACCATTCATGCAAAAAGCGTACGAGGTGTTTAT
GAACGGTTGCTAGAATTGGGAGTGACAGAAGCCGAGCTGAAAGTTGTTTTGCAAGGAATTTGCTACCAACGGTTAATTGC
GAAAGGAGGAATAGTGGATTTTGTCAGTGAAAGGTATCAAGAACACGAGCCAATCGATTGGAATCGACAGATTGATCAGC
TTCATGCAGCAGGACATATCAATCTTGAACAAGCAGAATCGGAAAAAATTATCCACGGTTAA

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-267)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I0SLG1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYA Streptococcus gordonii str. Challis substr. CH1

82.903

99.042

0.821
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

75.806

99.042

0.751
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

75.484

99.042

0.748
  comGA/cglA/cilD Streptococcus pneumoniae D39

75.484

99.042

0.748
  comGA/cglA/cilD Streptococcus pneumoniae R6

75.484

99.042

0.748
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

75.484

99.042

0.748
  comYA Streptococcus mutans UA159

63.666

99.361

0.633
  comYA Streptococcus mutans UA140

63.666

99.361

0.633
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

61.935

99.042

0.613
  comGA Lactococcus lactis subsp. cremoris KW2

54.019

99.361

0.537
  comGA Latilactobacillus sakei subsp. sakei 23K

43.542

86.581

0.377