Detailed information NTG0521117

Bioinformatically predicted

Overview

• Name: cinA
• Type: Machinery gene
• Locus tag: JCP75_RS13475
• Genome accession: NZ_CP066576
• Coordinates: 2748428..2749669 (-)
• Length: 413 a.a.
• NCBI ID: WP_002296026.1
• Uniprot ID: A0AAV3GRJ1
• Organism: Enterococcus faecium strain Dallas 100_1
• Function: facilitate localization of RecA (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
ICE	2726502..2748319	2748428..2749669	flank	109

Gene organization within MGE regions

Location: 2726502..2749669

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JCP75_RS13380 (JCP75_13380)	-	2726502..2727695 (-)	1194	WP_017143963.1	site-specific integrase	-
JCP75_RS13385 (JCP75_13385)	-	2727774..2727977 (-)	204	WP_002610247.1	excisionase	-
JCP75_RS13390 (JCP75_13390)	-	2727977..2729137 (-)	1161	WP_008816501.1	replication initiation factor domain-containing protein	-
JCP75_RS13395 (JCP75_13395)	-	2729533..2730204 (+)	672	WP_008393244.1	helix-turn-helix domain-containing protein	-
JCP75_RS13400 (JCP75_13400)	-	2730574..2731188 (+)	615	WP_008393242.1	helix-turn-helix domain-containing protein	-
JCP75_RS13405 (JCP75_13405)	-	2731421..2731765 (+)	345	Protein_2628	hypothetical protein	-
JCP75_RS13410 (JCP75_13410)	thiT	2731846..2732415 (-)	570	WP_002287348.1	energy-coupled thiamine transporter ThiT	-
JCP75_RS13415 (JCP75_13415)	-	2732589..2733560 (-)	972	WP_002287347.1	ribose-phosphate diphosphokinase	-
JCP75_RS13420 (JCP75_13420)	glmU	2733654..2735027 (-)	1374	WP_002287346.1	bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU	-
JCP75_RS13425 (JCP75_13425)	purR	2735530..2736348 (-)	819	WP_002287345.1	pur operon repressor	-
JCP75_RS13430 (JCP75_13430)	-	2736515..2737339 (-)	825	WP_002287344.1	metal ABC transporter permease	-
JCP75_RS13435 (JCP75_13435)	-	2737312..2737992 (-)	681	WP_002287343.1	metal ABC transporter ATP-binding protein	-
JCP75_RS13440 (JCP75_13440)	-	2738015..2738953 (-)	939	WP_002287342.1	metal ABC transporter substrate-binding protein	-
JCP75_RS13445 (JCP75_13445)	ispE	2739198..2740049 (-)	852	WP_002296028.1	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase	-
JCP75_RS13450 (JCP75_13450)	mprF	2740203..2742776 (-)	2574	WP_002287340.1	bifunctional lysylphosphatidylglycerol flippase/synthetase MprF	-
JCP75_RS13455 (JCP75_13455)	proC	2742917..2743723 (+)	807	WP_002296027.1	pyrroline-5-carboxylate reductase	-
JCP75_RS13460 (JCP75_13460)	-	2743915..2745216 (+)	1302	WP_002302440.1	ISL3 family transposase	-
JCP75_RS13465 (JCP75_13465)	rny	2745303..2746859 (-)	1557	WP_002287336.1	ribonuclease Y	-
JCP75_RS13470 (JCP75_13470)	recA	2747270..2748319 (-)	1050	WP_002287328.1	recombinase RecA	Machinery gene
JCP75_RS13475 (JCP75_13475)	cinA	2748428..2749669 (-)	1242	WP_002296026.1	competence/damage-inducible protein A	Machinery gene

Sequence

Protein

• Length: 413 a.a.
• Molecular weight: 45415.76 Da
• Isoelectric Point: 4.6507

>NTDB_id=521117 JCP75_RS13475 WP_002296026.1 2748428..2749669(-) (cinA) [Enterococcus faecium strain Dallas 100_1]
MKAEIIAVGTELLLGQVVNTNATFLSEQLADLGIEVYYQTVVGDNQQRLEELIALAETRSELILLCGGLGPTEDDLTKEA
TAAHLGKSLIQNTEGYKKLLAYFETTHRKMTKNNLQQSQIIEGGVPLPNRTGLALGTFYQTDTHAYILLPGPPNELKPMF
VEQVRPLLEERFPSEEKLISKVLRFYGIGESRLVTELKDLIETQINPTIAPYAKPNEVTLRLTVKTNDVQAGNQALLALE
EKIQERVGEYFYGYGDDNSLAKVVVELLKENKQTVTAAESLTAGAFQAALGDIAGVSEVFPGGFVTYSLQTKAGFLEIDP
ELLAEYGTVSKECVEQMAIQAREIARTDYSVAFTGVAGPDTLEGQSAGTVWIAISSKDGVVSEKYHFARDRAAIRYNAVM
QGFDLLRKQLLRK

Nucleotide

• Length: 1242 bp

>NTDB_id=521117 JCP75_RS13475 WP_002296026.1 2748428..2749669(-) (cinA) [Enterococcus faecium strain Dallas 100_1]
ATGAAAGCAGAAATAATAGCTGTCGGAACAGAACTTTTACTAGGACAAGTCGTGAATACGAATGCCACTTTCTTGTCAGA
ACAGCTAGCTGATCTAGGTATCGAAGTTTATTATCAAACAGTTGTAGGAGATAATCAGCAGCGTTTAGAAGAGTTGATTG
CTCTAGCTGAAACAAGAAGTGAACTCATACTCTTATGTGGCGGATTAGGACCGACAGAAGATGACCTGACAAAAGAAGCA
ACTGCGGCTCACCTCGGTAAGTCTCTCATACAAAATACGGAAGGATACAAAAAATTATTGGCATATTTTGAAACAACCCA
TCGAAAAATGACCAAAAACAATCTGCAACAGTCCCAGATTATCGAAGGCGGGGTTCCTCTACCAAATCGTACAGGGCTTG
CTTTAGGGACTTTTTATCAAACAGATACACATGCGTATATCCTTCTTCCCGGTCCGCCTAATGAGTTGAAACCAATGTTT
GTGGAACAAGTACGTCCTTTACTAGAGGAACGTTTTCCTTCTGAAGAAAAACTAATTTCTAAAGTTTTGCGCTTTTATGG
GATTGGTGAATCGCGACTGGTCACTGAGCTAAAAGATCTGATTGAGACACAGATCAATCCAACGATCGCACCATATGCCA
AACCAAATGAAGTGACATTACGACTGACAGTGAAAACAAATGATGTTCAGGCAGGGAATCAAGCTCTTTTAGCATTAGAA
GAAAAAATCCAAGAACGAGTAGGGGAATATTTTTATGGATACGGCGATGATAATTCGCTAGCAAAAGTCGTAGTGGAACT
ACTGAAAGAAAACAAGCAGACTGTAACAGCAGCGGAAAGTTTGACAGCCGGCGCCTTCCAAGCCGCATTAGGCGACATTG
CTGGTGTATCTGAAGTATTTCCAGGCGGATTCGTTACCTACTCGCTCCAAACAAAAGCTGGTTTTCTGGAGATTGATCCG
GAGCTATTAGCAGAATATGGAACAGTCAGCAAAGAATGTGTGGAGCAGATGGCCATTCAAGCACGTGAGATAGCAAGAAC
AGATTACAGTGTAGCTTTCACCGGAGTGGCTGGACCGGACACGTTAGAAGGTCAATCTGCAGGAACAGTATGGATCGCTA
TTTCATCTAAAGACGGCGTGGTTTCGGAAAAATATCACTTTGCCAGAGATCGTGCTGCTATCAGATATAATGCGGTTATG
CAAGGATTTGATCTTTTGAGAAAACAGCTTTTAAGAAAATGA

Domains

Predicted by InterproScan.

• Probable molybdopterin binding domain (MoCF_biosynth) (5-169)

• Competence-damaged protein (CinA) (258-410)

• Damage-inducible protein CinA KH domain (CinA_KH) (180-253)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cinA	Streptococcus mitis SK321	51.19	100	0.521
cinA	Streptococcus mutans UA159	51.566	100	0.518
cinA	Streptococcus pneumoniae TIGR4	50.952	100	0.518
cinA	Streptococcus pneumoniae D39	50.714	100	0.516
cinA	Streptococcus pneumoniae R6	50.714	100	0.516
cinA	Streptococcus pneumoniae Rx1	50.714	100	0.516
cinA	Streptococcus mitis NCTC 12261	50.714	100	0.516
cinA	Bacillus subtilis subsp. subtilis str. 168	47.573	99.758	0.475
cinA	Streptococcus suis isolate S10	41.787	100	0.419