Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYA   Type   Machinery gene
Locus tag   IB937_RS00670 Genome accession   NZ_CP061132
Coordinates   105481..106419 (+) Length   312 a.a.
NCBI ID   WP_136278207.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain BSAC_bs1388 isolate Invasive disease     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 100481..111419
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IB937_RS00660 (IB937_00660) rpoC 101230..104871 (+) 3642 WP_011528160.1 DNA-directed RNA polymerase subunit beta' -
  IB937_RS00665 (IB937_00665) - 105023..105388 (+) 366 WP_002986560.1 DUF1033 family protein -
  IB937_RS00670 (IB937_00670) comYA 105481..106419 (+) 939 WP_136278207.1 competence type IV pilus ATPase ComGA Machinery gene
  IB937_RS00675 (IB937_00675) comYB 106355..107389 (+) 1035 WP_011054115.1 competence type IV pilus assembly protein ComGB Machinery gene
  IB937_RS00680 (IB937_00680) comYC 107391..107717 (+) 327 WP_011528161.1 competence type IV pilus major pilin ComGC Machinery gene
  IB937_RS00685 (IB937_00685) comGD 107692..108120 (+) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD -
  IB937_RS00690 (IB937_00690) comGE 108077..108361 (+) 285 WP_011528162.1 competence type IV pilus minor pilin ComGE -
  IB937_RS00695 (IB937_00695) comYF 108354..108788 (+) 435 WP_002992738.1 competence type IV pilus minor pilin ComGF Machinery gene
  IB937_RS00700 (IB937_00700) comGG 108772..109098 (+) 327 WP_010921801.1 competence type IV pilus minor pilin ComGG -
  IB937_RS00705 (IB937_00705) comYH 109196..110149 (+) 954 WP_021299429.1 class I SAM-dependent methyltransferase Machinery gene
  IB937_RS00710 (IB937_00710) - 110208..111404 (+) 1197 WP_011528164.1 acetate kinase -

Sequence

Protein


Download         Length: 312 a.a.        Molecular weight: 35060.33 Da        Isoelectric Point: 8.5799

>NTDB_id=480847 IB937_RS00670 WP_136278207.1 105481..106419(+) (comYA) [Streptococcus pyogenes strain BSAC_bs1388 isolate Invasive disease]
MVQALAKAILAKAEQVQAQDIYILPRADQYDLFLRIGDERRLVDVYQSDRMAPLISHFKFVAGMIVGEKRRCQVGSCDYK
LSKDKQLSLRLSSVGDYRGQESLVIRLLHHQNKSVHYWFDGLTKVANQVGGRGLYLFAGPVGSGKTTLMYQLISSYHQEA
QVISIEDPVEIKNHQILQLQVNDDIGMTYDNLIKLSLRHRPDILVIGEIRDSQTARAVIRASLTGAMIFSTVHAKSISGV
YARLLELGITKAELSNCLALIAYQRLLNGGALIDSTQNEFEYYSSSNWNQQIDQLLEAGHLNPKQAKLEKII

Nucleotide


Download         Length: 939 bp        

>NTDB_id=480847 IB937_RS00670 WP_136278207.1 105481..106419(+) (comYA) [Streptococcus pyogenes strain BSAC_bs1388 isolate Invasive disease]
ATGGTACAAGCATTAGCAAAAGCTATTCTAGCAAAAGCTGAACAGGTTCAGGCACAAGATATTTATATTTTGCCAAGAGC
AGATCAATATGATCTTTTTTTACGAATAGGAGATGAAAGGAGATTAGTTGATGTTTATCAGAGCGATCGGATGGCTCCTC
TTATTAGTCACTTTAAATTCGTTGCAGGAATGATAGTTGGTGAAAAGAGACGTTGTCAGGTGGGTTCATGTGATTATAAG
CTTAGTAAAGATAAGCAGTTATCTTTGCGCTTATCTAGCGTGGGTGATTATCGCGGGCAAGAAAGCTTAGTGATTCGTCT
GCTTCATCATCAAAATAAAAGTGTACATTATTGGTTTGATGGATTGACAAAAGTAGCCAATCAAGTTGGCGGTAGAGGGT
TGTATTTATTTGCAGGACCAGTTGGGTCTGGGAAGACAACCTTGATGTACCAGCTGATTTCGAGTTATCATCAAGAAGCA
CAGGTTATTAGTATAGAAGATCCTGTAGAAATTAAAAATCACCAAATTTTACAATTACAAGTGAATGATGATATTGGTAT
GACTTATGACAATTTGATCAAACTGTCTTTACGCCATCGACCAGATATTTTAGTTATTGGTGAGATTCGAGATAGTCAAA
CAGCAAGAGCCGTTATTAGGGCTAGTCTAACAGGTGCCATGATTTTTTCAACGGTTCACGCTAAAAGTATCTCGGGTGTT
TATGCAAGATTGTTAGAACTTGGTATAACGAAAGCAGAACTGTCTAATTGCTTAGCATTAATTGCTTACCAAAGGTTACT
TAATGGAGGAGCATTGATTGACTCTACTCAAAACGAATTTGAATATTATTCCTCATCGAACTGGAATCAACAAATTGATC
AGCTTCTTGAGGCAGGACATCTCAATCCCAAGCAAGCTAAGCTTGAAAAAATTATCTAG

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-267)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYA Streptococcus mutans UA140

61.415

99.679

0.612
  comYA Streptococcus mutans UA159

61.415

99.679

0.612
  comYA Streptococcus gordonii str. Challis substr. CH1

60.129

99.679

0.599
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

60

99.359

0.596
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

59.164

99.679

0.59
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

58.521

99.679

0.583
  comGA/cglA/cilD Streptococcus pneumoniae D39

58.521

99.679

0.583
  comGA/cglA/cilD Streptococcus pneumoniae R6

58.521

99.679

0.583
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

58.521

99.679

0.583
  comGA Lactococcus lactis subsp. cremoris KW2

50.161

99.679

0.5
  comGA Latilactobacillus sakei subsp. sakei 23K

39.655

92.949

0.369