Detailed information NTG0453504

Bioinformatically predicted

Overview

• Name: comEA
• Type: Machinery gene
• Locus tag: FOC72_RS06730
• Genome accession: NZ_CP054570
• Coordinates: 1415733..1416413 (-)
• Length: 226 a.a.
• NCBI ID: WP_032914217.1
• Uniprot ID: A0A859EQ31
• Organism: Streptococcus sanguinis strain FDAARGOS_770
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1410733..1421413

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FOC72_RS06715 (FOC72_06715)	holA	1410946..1411992 (-)	1047	WP_002896082.1	DNA polymerase III subunit delta	-
FOC72_RS06720 (FOC72_06720)	-	1412243..1413379 (-)	1137	WP_002896085.1	DUF805 domain-containing protein	-
FOC72_RS06725 (FOC72_06725)	comEC/celB	1413509..1415749 (-)	2241	WP_002896086.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
FOC72_RS06730 (FOC72_06730)	comEA	1415733..1416413 (-)	681	WP_032914217.1	helix-hairpin-helix domain-containing protein	Machinery gene
FOC72_RS06735 (FOC72_06735)	-	1416561..1417109 (-)	549	WP_002896088.1	HXXEE domain-containing protein	-
FOC72_RS06740 (FOC72_06740)	-	1417182..1417922 (-)	741	WP_002896089.1	1-acyl-sn-glycerol-3-phosphate acyltransferase	-
FOC72_RS06745 (FOC72_06745)	-	1418080..1420419 (+)	2340	WP_002896090.1	cation-translocating P-type ATPase	-
FOC72_RS06750 (FOC72_06750)	-	1420549..1421295 (+)	747	WP_002896091.1	tRNA1(Val) (adenine(37)-N6)-methyltransferase	-

Sequence

Protein

• Length: 226 a.a.
• Molecular weight: 24037.88 Da
• Isoelectric Point: 4.9291

>NTDB_id=453504 FOC72_RS06730 WP_032914217.1 1415733..1416413(-) (comEA) [Streptococcus sanguinis strain FDAARGOS_770]
MLEEIIEKLKEYKLFVGLAVVGAVLGSFFLIKGNHQPQNQVTALSQEITSSSSSADEKSEKIVSKDKADEEESEQVTVDI
KGAVKNPGVYELRAGARVHEAIQKAGGLIADAEAKSINQAQKLTDEAVIYVAKIGEEGADVTQSGQHQAGASDSAGASGG
KSDKVNLNTAKEAELQTISGIGQKRASDIIAYRESNGRFKSVDDLKKVSGIGDKTLEKLKEYVTVD

Nucleotide

• Length: 681 bp

>NTDB_id=453504 FOC72_RS06730 WP_032914217.1 1415733..1416413(-) (comEA) [Streptococcus sanguinis strain FDAARGOS_770]
ATGCTTGAAGAAATCATTGAAAAGCTGAAAGAATACAAGCTCTTTGTCGGTCTGGCAGTAGTTGGCGCTGTGCTAGGTAG
TTTTTTCCTTATCAAAGGAAATCATCAACCGCAAAATCAAGTAACCGCCTTGAGCCAAGAAATAACTTCCTCATCCAGCT
CAGCTGATGAAAAAAGCGAAAAGATTGTCTCTAAGGATAAGGCGGACGAAGAGGAAAGCGAGCAGGTCACTGTGGATATT
AAAGGAGCAGTTAAGAATCCTGGTGTCTATGAGCTGAGAGCAGGAGCGAGAGTGCATGAAGCCATCCAAAAAGCTGGCGG
ATTGATAGCAGACGCCGAGGCTAAGTCCATTAATCAGGCACAAAAATTAACGGATGAAGCAGTAATCTATGTGGCAAAGA
TTGGTGAAGAAGGAGCTGATGTCACACAGAGTGGCCAGCATCAAGCAGGAGCTTCTGATTCTGCTGGTGCCAGTGGTGGA
AAGTCGGACAAGGTCAATCTAAATACGGCGAAAGAGGCTGAATTACAGACCATTTCAGGCATCGGACAGAAGCGAGCTTC
TGACATCATAGCCTACCGCGAAAGCAATGGCCGCTTCAAGTCAGTAGATGATCTGAAAAAAGTGTCAGGGATTGGAGATA
AGACCTTAGAAAAGCTGAAAGAATATGTCACAGTGGATTAA

Domains

Predicted by InterproScan.

• Helix-hairpin-helix motif (HHH_3) (162-224)

• SLBB domain (SLBB) (78-131)

3D structure

• AlphaFold DB: A0A859EQ31

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA	Streptococcus thermophilus LMD-9	49.356	100	0.509
comEA/celA/cilE	Streptococcus mitis SK321	48.276	100	0.496
comEA/celA/cilE	Streptococcus pneumoniae R6	47.414	100	0.487
comEA/celA/cilE	Streptococcus pneumoniae Rx1	47.414	100	0.487
comEA/celA/cilE	Streptococcus pneumoniae D39	47.414	100	0.487
comEA/celA/cilE	Streptococcus mitis NCTC 12261	48.889	99.558	0.487
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	48	99.558	0.478
comEA	Lactococcus lactis subsp. cremoris KW2	40.889	99.558	0.407
comEA	Bacillus subtilis subsp. subtilis str. 168	41.818	97.345	0.407
comEA	Latilactobacillus sakei subsp. sakei 23K	35.102	100	0.381