Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   MGAS15252_RS07945 Genome accession   NC_017040
Coordinates   1655451..1656722 (-) Length   423 a.a.
NCBI ID   WP_014407933.1    Uniprot ID   -
Organism   Streptococcus pyogenes MGAS15252     
Function   require for competence (predicted from homology)   
Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1645729..1673573 1655451..1656722 within 0


Gene organization within MGE regions


Location: 1645729..1673573
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS15252_RS07895 (MGAS15252_1634) nrdG 1645729..1646343 (-) 615 WP_002982219.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  MGAS15252_RS07900 (MGAS15252_1635) - 1646358..1646852 (-) 495 WP_014407930.1 GNAT family N-acetyltransferase -
  MGAS15252_RS07905 (MGAS15252_1636) - 1646861..1647796 (-) 936 WP_009880789.1 Gfo/Idh/MocA family protein -
  MGAS15252_RS09105 (MGAS15252_1637) - 1647825..1647971 (-) 147 WP_002982210.1 hypothetical protein -
  MGAS15252_RS07910 (MGAS15252_1638) nrdD 1648153..1650351 (-) 2199 WP_002992831.1 anaerobic ribonucleoside-triphosphate reductase -
  MGAS15252_RS07915 (MGAS15252_1639) - 1650448..1652007 (-) 1560 WP_014407931.1 membrane protein -
  MGAS15252_RS07920 (MGAS15252_1640) - 1652420..1652725 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  MGAS15252_RS07925 (MGAS15252_1641) ruvX 1652737..1653156 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  MGAS15252_RS07930 (MGAS15252_1642) - 1653153..1653422 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  MGAS15252_RS07935 (MGAS15252_1643) spx 1653537..1653935 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  MGAS15252_RS07940 (MGAS15252_1644) recA 1654226..1655362 (-) 1137 WP_014407932.1 recombinase RecA Machinery gene
  MGAS15252_RS07945 (MGAS15252_1645) cinA 1655451..1656722 (-) 1272 WP_014407933.1 competence/damage-inducible protein A Machinery gene
  MGAS15252_RS07950 (MGAS15252_1646) - 1656791..1657351 (-) 561 WP_010922755.1 DNA-3-methyladenine glycosylase I -
  MGAS15252_RS07955 (MGAS15252_1647) ruvA 1657361..1657957 (-) 597 WP_002992186.1 Holliday junction branch migration protein RuvA -
  MGAS15252_RS07960 (MGAS15252_1648) - 1657959..1659179 (-) 1221 WP_014407934.1 MDR family MFS transporter -
  MGAS15252_RS07965 (MGAS15252_1649) mutL 1659190..1661172 (-) 1983 WP_014407935.1 DNA mismatch repair endonuclease MutL -
  MGAS15252_RS07970 (MGAS15252_1650) - 1661267..1662418 (-) 1152 WP_014407936.1 tyrosine-type recombinase/integrase -
  MGAS15252_RS09255 (MGAS15252_1651) - 1662740..1662883 (+) 144 WP_011185066.1 putative holin-like toxin -
  MGAS15252_RS07975 (MGAS15252_1652) - 1663755..1664435 (-) 681 WP_011185067.1 helix-turn-helix domain-containing protein -
  MGAS15252_RS07980 (MGAS15252_1653) - 1664599..1664796 (+) 198 WP_011185068.1 helix-turn-helix domain-containing protein -
  MGAS15252_RS07985 (MGAS15252_1654) - 1664810..1665418 (+) 609 WP_014407937.1 phage repressor protein -
  MGAS15252_RS07990 (MGAS15252_1655) - 1665439..1665846 (+) 408 WP_011185070.1 hypothetical protein -
  MGAS15252_RS07995 (MGAS15252_1656) - 1665860..1666477 (+) 618 WP_014407938.1 Rha family transcriptional regulator -
  MGAS15252_RS08000 (MGAS15252_1657) - 1666722..1667054 (+) 333 WP_014407939.1 hypothetical protein -
  MGAS15252_RS08005 (MGAS15252_1658) - 1667054..1667245 (+) 192 WP_080011075.1 hypothetical protein -
  MGAS15252_RS08010 (MGAS15252_1659) - 1667257..1667619 (+) 363 WP_000206026.1 hypothetical protein -
  MGAS15252_RS08015 (MGAS15252_1660) - 1667616..1667945 (+) 330 WP_000174505.1 hypothetical protein -
  MGAS15252_RS08020 (MGAS15252_1661) - 1667948..1668220 (+) 273 WP_014407941.1 hypothetical protein -
  MGAS15252_RS08025 (MGAS15252_1662) - 1668221..1669078 (+) 858 WP_014407942.1 primase alpha helix C-terminal domain-containing protein -
  MGAS15252_RS08030 (MGAS15252_1663) - 1669047..1670735 (+) 1689 WP_014407943.1 DNA primase family protein -
  MGAS15252_RS08910 (MGAS15252_1664) - 1671022..1671195 (+) 174 WP_000694577.1 hypothetical protein -
  MGAS15252_RS09110 (MGAS15252_1665) - 1671201..1671374 (+) 174 WP_014407944.1 hypothetical protein -
  MGAS15252_RS08045 (MGAS15252_1666) - 1671376..1671885 (+) 510 WP_014407945.1 hypothetical protein -
  MGAS15252_RS08050 (MGAS15252_1667) - 1671959..1672447 (+) 489 WP_014407946.1 hypothetical protein -
  MGAS15252_RS08055 (MGAS15252_1668) - 1672853..1673215 (+) 363 WP_014407947.1 DUF1492 domain-containing protein -
  MGAS15252_RS08060 (MGAS15252_1669) - 1673190..1673573 (+) 384 WP_014407948.1 ArpU family phage packaging/lysis transcriptional regulator -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45980.70 Da        Isoelectric Point: 4.8322

>NTDB_id=44419 MGAS15252_RS07945 WP_014407933.1 1655451..1656722(-) (cinA) [Streptococcus pyogenes MGAS15252]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFSGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=44419 MGAS15252_RS07945 WP_014407933.1 1655451..1656722(-) (cinA) [Streptococcus pyogenes MGAS15252]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTAATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTTCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACGGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGTCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Competence-damaged protein (CinA)

(263-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.74

100

0.697
  cinA Streptococcus mitis SK321

70.264

98.582

0.693
  cinA Streptococcus mitis NCTC 12261

69.784

98.582

0.688
  cinA Streptococcus pneumoniae TIGR4

68.825

98.582

0.678
  cinA Streptococcus pneumoniae Rx1

68.825

98.582

0.678
  cinA Streptococcus pneumoniae R6

68.825

98.582

0.678
  cinA Streptococcus pneumoniae D39

68.585

98.582

0.676
  cinA Streptococcus suis isolate S10

53.125

98.345

0.522
  cinA Bacillus subtilis subsp. subtilis str. 168

46.89

98.818

0.463

Multiple sequence alignment