Detailed information NTG0443488

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: HKM25_RS11350
• Genome accession: NZ_CP053210
• Coordinates: 2214600..2215352 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 6A-10
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2209600..2220352

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HKM25_RS11870	-	2212034..2213636 (-)	1603	Protein_2213	YhgE/Pip domain-containing protein	-
HKM25_RS11335 (HKM25_2329)	-	2213815..2214357 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
HKM25_RS11350 (HKM25_2332)	comE	2214600..2215352 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
HKM25_RS11355 (HKM25_2333)	comD/comD2	2215349..2216674 (-)	1326	WP_000364845.1	competence system sensor histidine kinase ComD	Regulator
HKM25_RS11360 (HKM25_2334)	comC/comC2	2216695..2216820 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
HKM25_RS11370 (HKM25_2336)	rlmH	2217102..2217581 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
HKM25_RS11375 (HKM25_2337)	htrA	2217764..2218945 (+)	1182	WP_000681597.1	trypsin-like peptidase domain-containing protein	Regulator
HKM25_RS11380 (HKM25_2338)	spo0J	2219003..2219761 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=443488 HKM25_RS11350 WP_000866065.1 2214600..2215352(-) (comE) [Streptococcus pneumoniae strain 6A-10]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=443488 HKM25_RS11350 WP_000866065.1 2214600..2215352(-) (comE) [Streptococcus pneumoniae strain 6A-10]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408