Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC2   Type   Regulator
Locus tag   HKM25_RS11360 Genome accession   NZ_CP053210
Coordinates   2216695..2216820 (-) Length   41 a.a.
NCBI ID   WP_000799686.1    Uniprot ID   P60242
Organism   Streptococcus pneumoniae strain 6A-10     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 2211695..2221820
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HKM25_RS11870 - 2212034..2213636 (-) 1603 Protein_2213 YhgE/Pip domain-containing protein -
  HKM25_RS11335 (HKM25_2329) - 2213815..2214357 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  HKM25_RS11350 (HKM25_2332) comE 2214600..2215352 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  HKM25_RS11355 (HKM25_2333) comD/comD2 2215349..2216674 (-) 1326 WP_000364845.1 competence system sensor histidine kinase ComD Regulator
  HKM25_RS11360 (HKM25_2334) comC/comC2 2216695..2216820 (-) 126 WP_000799686.1 competence-stimulating peptide ComC Regulator
  HKM25_RS11370 (HKM25_2336) rlmH 2217102..2217581 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  HKM25_RS11375 (HKM25_2337) htrA 2217764..2218945 (+) 1182 WP_000681597.1 trypsin-like peptidase domain-containing protein Regulator
  HKM25_RS11380 (HKM25_2338) spo0J 2219003..2219761 (+) 759 WP_000410378.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4907.00 Da        Isoelectric Point: 11.0006

>NTDB_id=443490 HKM25_RS11360 WP_000799686.1 2216695..2216820(-) (comC/comC2) [Streptococcus pneumoniae strain 6A-10]
MKNTVKLEQFVALKEKDLQKIKGGEMRISRIILDFLFLRKK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=443490 HKM25_RS11360 WP_000799686.1 2216695..2216820(-) (comC/comC2) [Streptococcus pneumoniae strain 6A-10]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAAGATTAAAGGTGGGGAGATGAG
GATTTCAAGAATCATCCTTGATTTTCTTTTCCTACGAAAAAAGTAA

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-29)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 6CJ8
  PDB 6COO
  PDB 6COP
  PDB 6COQ
  PDB 6COR
  PDB 6COS
  PDB 6COW
  PDB 6OBW
  PDB 6OC2
  PDB 6OC4
  PDB 6OLD
  PDB 6V1N

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC2 Streptococcus pneumoniae A66

100

100

1
  comC/comC2 Streptococcus pneumoniae TIGR4

100

100

1
  comC/comC1 Streptococcus pneumoniae R6

80.488

100

0.805
  comC/comC1 Streptococcus pneumoniae G54

80.488

100

0.805
  comC/comC1 Streptococcus pneumoniae D39

80.488

100

0.805
  comC/comC1 Streptococcus pneumoniae Rx1

80.488

100

0.805
  comC Streptococcus mitis SK321

75.61

100

0.756
  comC Streptococcus mitis NCTC 12261

57.5

97.561

0.561