Detailed information    

insolico Bioinformatically predicted

Overview

Name   pilC   Type   Machinery gene
Locus tag   HHA37_RS23550 Genome accession   NZ_CP051547
Coordinates   5091253..5092470 (+) Length   405 a.a.
NCBI ID   WP_010792214.1    Uniprot ID   A0A643EEA0
Organism   Pseudomonas aeruginosa strain AA2     
Function   assembly of type IV pilus (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 5091253..5099953 5091253..5092470 within 0


Gene organization within MGE regions


Location: 5091253..5099953
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HHA37_RS23550 (HHA37_23585) pilC 5091253..5092470 (+) 1218 WP_010792214.1 type II secretion system F family protein Machinery gene
  HHA37_RS23555 (HHA37_23590) pilD 5092473..5093345 (+) 873 WP_023911898.1 type IV prepilin peptidase/methyltransferase PilD Machinery gene
  HHA37_RS23560 (HHA37_23595) coaE 5093342..5093953 (+) 612 WP_003094654.1 dephospho-CoA kinase -
  HHA37_RS23565 (HHA37_23600) yacG 5093950..5094150 (+) 201 WP_003094656.1 DNA gyrase inhibitor YacG -
  HHA37_RS23570 (HHA37_23605) - 5094187..5094396 (-) 210 WP_003094660.1 hypothetical protein -
  HHA37_RS23575 (HHA37_23610) - 5094502..5095191 (-) 690 WP_003103868.1 energy-coupling factor ABC transporter permease -
  HHA37_RS23580 (HHA37_23615) - 5095188..5095658 (-) 471 WP_023911895.1 hypothetical protein -
  HHA37_RS23585 (HHA37_23620) - 5095655..5096080 (-) 426 WP_003103865.1 GNAT family N-acetyltransferase -
  HHA37_RS23590 (HHA37_23625) - 5096213..5096842 (+) 630 WP_003120948.1 DUF1780 domain-containing protein -
  HHA37_RS23595 (HHA37_23630) - 5096839..5097288 (+) 450 WP_003094670.1 MOSC domain-containing protein -
  HHA37_RS23600 (HHA37_23635) - 5097314..5097484 (+) 171 WP_003094672.1 DUF3094 family protein -
  HHA37_RS23605 (HHA37_23640) - 5097548..5098855 (+) 1308 WP_003125206.1 NAD(P)/FAD-dependent oxidoreductase -

Sequence

Protein


Download         Length: 405 a.a.        Molecular weight: 44242.19 Da        Isoelectric Point: 9.8988

>NTDB_id=439720 HHA37_RS23550 WP_010792214.1 5091253..5092470(+) (pilC) [Pseudomonas aeruginosa strain AA2]
MADKALKTCVFVWEGTDKKGAKVKGELAGQNTMLVKAQLRKQGINPLKVRKKGITLLGKGKRVKPMDIALFTRQMATMMG
AGVPLLQSFDIISEGFDNPNMRKLVDEIKQEVSAGNSLANSLRKKPLYFDDLYCNLVDAGEQSGALETLLDRVATYKEKT
ESLKAKIKKAMTYPIAVVLVAIIVSAILLIKVVPQFQSVFSSFGAELPAFTMMVINLSNLLQEWWLVVLIGLFSASFAIK
ESHKRSVNFRNTVDRYMLKIPIIGGILYKSAVARYARTLSTTFAAGVPLVEALDSVSGATGNVVFRNAVSKIKQDVSTGM
QLNFSMRTTNVFPNMAIQMTAIGEESGSLDDMLGKVAAFYEEEVDNAVDNLTTLMEPMIMAVLGVLVGGLIIAMYLPIFQ
LGSVV

Nucleotide


Download         Length: 1218 bp        

>NTDB_id=439720 HHA37_RS23550 WP_010792214.1 5091253..5092470(+) (pilC) [Pseudomonas aeruginosa strain AA2]
ATGGCGGATAAAGCGTTAAAAACCTGTGTTTTCGTCTGGGAAGGCACGGACAAGAAAGGGGCAAAGGTCAAGGGGGAGTT
GGCTGGCCAGAACACTATGCTGGTGAAGGCGCAACTGCGCAAACAGGGCATAAATCCGCTCAAGGTCAGAAAAAAGGGCA
TTACCCTTCTCGGCAAGGGAAAGCGCGTAAAGCCGATGGACATCGCACTATTTACTCGTCAGATGGCAACCATGATGGGT
GCTGGGGTTCCTCTCTTGCAATCGTTCGACATAATTTCCGAAGGTTTCGACAATCCCAACATGCGTAAGCTGGTCGACGA
GATCAAACAAGAGGTCTCGGCGGGTAACAGCCTGGCAAACTCCTTGCGAAAGAAACCTCTTTATTTTGACGATCTCTATT
GCAACCTGGTGGATGCAGGTGAACAATCTGGCGCCTTGGAGACTTTGCTTGACCGTGTTGCCACCTATAAGGAAAAAACC
GAATCGCTAAAAGCCAAGATAAAAAAGGCTATGACATACCCCATTGCCGTCGTCTTGGTCGCGATCATTGTTTCAGCCAT
TCTCCTGATCAAGGTCGTACCCCAGTTCCAATCCGTTTTCTCCAGTTTCGGAGCGGAACTACCAGCCTTTACAATGATGG
TGATAAACCTGTCAAATCTTTTACAGGAATGGTGGCTAGTCGTCCTCATCGGATTATTCAGCGCCAGCTTCGCCATCAAG
GAATCGCATAAGCGTTCAGTAAATTTCCGTAACACGGTAGACCGCTATATGTTGAAAATACCGATAATCGGAGGAATACT
TTACAAATCAGCCGTGGCACGTTACGCCCGTACACTTTCAACAACTTTCGCCGCAGGTGTTCCATTGGTGGAGGCACTAG
ACTCTGTCTCTGGAGCGACAGGAAACGTGGTATTCCGCAACGCGGTAAGCAAGATCAAACAGGATGTATCCACAGGTATG
CAATTGAACTTCTCCATGAGAACGACCAATGTATTCCCCAACATGGCAATCCAGATGACAGCCATCGGTGAGGAATCCGG
TTCTCTGGACGACATGTTGGGCAAGGTGGCTGCGTTCTATGAGGAGGAAGTAGACAATGCCGTCGACAATCTGACAACTC
TCATGGAACCTATGATCATGGCCGTGCTCGGCGTACTGGTCGGCGGCCTGATCATCGCTATGTATCTACCGATCTTCCAA
CTGGGTTCCGTTGTGTAA

Domains

Predicted by InterproScan.

Type II secretion system (T2SS), protein F (T2SSF)

(276-397)

Type II secretion system (T2SS), protein F (T2SSF)

(71-194)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A643EEA0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pilC Pseudomonas stutzeri DSM 10701

78.765

100

0.788
  pilC Acinetobacter baumannii D1279779

58.911

99.753

0.588
  pilC Acinetobacter baylyi ADP1

59.045

98.272

0.58
  pilC Legionella pneumophila strain ERS1305867

54.293

97.778

0.531
  pilG Neisseria meningitidis 44/76-A

44.03

99.259

0.437
  pilG Neisseria gonorrhoeae MS11

43.781

99.259

0.435
  pilC Vibrio cholerae strain A1552

43.21

100

0.432
  pilC Vibrio campbellii strain DS40M4

43.182

97.778

0.422
  pilC Thermus thermophilus HB27

37.406

99.012

0.37