Detailed information NTG0430583

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: HA248_RS11105
• Genome accession: NZ_CP050175
• Coordinates: 2138312..2139064 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain PZ900701590
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2133312..2144064

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HA248_RS11775 (HA248_11060)	-	2135745..2137348 (-)	1604	Protein_2141	YhgE/Pip family protein	-
HA248_RS11090 (HA248_11065)	-	2137527..2138069 (+)	543	WP_033705079.1	TetR/AcrR family transcriptional regulator	-
HA248_RS11105 (HA248_11080)	comE	2138312..2139064 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
HA248_RS11110 (HA248_11085)	comD/comD1	2139061..2140386 (-)	1326	WP_033705078.1	competence system sensor histidine kinase ComD	Regulator
HA248_RS11115 (HA248_11090)	comC/comC1	2140407..2140532 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
HA248_RS11125 (HA248_11100)	rlmH	2140814..2141293 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
HA248_RS11130 (HA248_11105)	htrA	2141476..2142657 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
HA248_RS11135 (HA248_11110)	spo0J	2142715..2143473 (+)	759	WP_000410380.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=430583 HA248_RS11105 WP_000866065.1 2138312..2139064(-) (comE) [Streptococcus pneumoniae strain PZ900701590]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=430583 HA248_RS11105 WP_000866065.1 2138312..2139064(-) (comE) [Streptococcus pneumoniae strain PZ900701590]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACATATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGATAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408