Detailed information NTG0430586

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: HA248_RS11130
• Genome accession: NZ_CP050175
• Coordinates: 2141476..2142657 (+)
• Length: 393 a.a.
• NCBI ID: WP_000681597.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain PZ900701590
• Function: degrading CSP; selective degradation of ComEA and ComEC (predicted from homology) Competence regulation

Genomic Context

Location: 2136476..2147657

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HA248_RS11090 (HA248_11065)	-	2137527..2138069 (+)	543	WP_033705079.1	TetR/AcrR family transcriptional regulator	-
HA248_RS11105 (HA248_11080)	comE	2138312..2139064 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
HA248_RS11110 (HA248_11085)	comD/comD1	2139061..2140386 (-)	1326	WP_033705078.1	competence system sensor histidine kinase ComD	Regulator
HA248_RS11115 (HA248_11090)	comC/comC1	2140407..2140532 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
HA248_RS11125 (HA248_11100)	rlmH	2140814..2141293 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
HA248_RS11130 (HA248_11105)	htrA	2141476..2142657 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
HA248_RS11135 (HA248_11110)	spo0J	2142715..2143473 (+)	759	WP_000410380.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41841.72 Da
• Isoelectric Point: 6.8902

>NTDB_id=430586 HA248_RS11130 WP_000681597.1 2141476..2142657(+) (htrA) [Streptococcus pneumoniae strain PZ900701590]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVI
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=430586 HA248_RS11130 WP_000681597.1 2141476..2142657(+) (htrA) [Streptococcus pneumoniae strain PZ900701590]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAAATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAATT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (289-384)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus pneumoniae Rx1	100	100	1
htrA	Streptococcus pneumoniae D39	100	100	1
htrA	Streptococcus pneumoniae R6	100	100	1
htrA	Streptococcus pneumoniae TIGR4	100	100	1
htrA	Streptococcus mitis NCTC 12261	97.201	100	0.972
htrA	Streptococcus gordonii str. Challis substr. CH1	66.414	100	0.669
htrA	Streptococcus mutans UA159	54.569	100	0.547